haldujai

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391.
by haldujai 3y ago
They include an off-hours subgroup which comprises of weekday after hours as well as weekends and represents 2/3rds of cases. They don't provide a further breakdown but in this after-hours group delayed presentation was even lower
392.
by haldujai 3y ago
We've had computer-reads/AI on ECGs since I was a medical student. Really good at detecting normal, bad at everything else. US/Can healthcare systems still pay a cardiologist a couple of bucks to "finalize" the inte
393.
by haldujai 3y ago
Agree in general, even if one knew this at one point or know the textbook appearances patients don't read textbooks and there's nuance to everything. Unless you're actively exposed to/interpreting ECGs in clinical practi
394.
by haldujai 3y ago
Not for a STEMI specifically, it’s one of two ECG patterns even a radiologist like me knows how to read. This is a stronger argument for other diseases. Door to balloon target in STEMI is 90 minutes. STEMI centers (this is picked up by EMS
395.
by haldujai 3y ago
From the methods section of the abstract: “We excluded post-fibrinolysis patients, patients with old stents, and those who presented more than 24 hours after the onset of pain.”[edit: I misread the PDF version which included multiple abstr
396.
by haldujai 3y ago
> Histological classifications become less and less relevant What do you mean by "histological classification" because every interpretation I can think of is very incorrect.
397.
by haldujai 3y ago
> It costs about $7000 in Europe (the price seems to be similar in different country even though there is no EU wide collective negotiation). That seems like a monthly price? The treatment regimen in this study is daily for 3 years. It&#
398.
by haldujai 3y ago
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627907/ Non-inferiority studies aren't sufficiently powered to answer the question but up-front Docetaxel is pretty old-school. My urology days are long
399.
by haldujai 3y ago
Small-cell (SCLC) is definitely very aggressive and more strongly associated with smoking than non-small cell lung cancer (NSCLC), I'm not sure about 99% but that seems too high. It's fairly rare though, the quoted numbers from SE
400.
by haldujai 3y ago
> I could be wrong. Absolutely. I am always open to more information. You're still a bit too cynical but there are some nuggets of truth in what you're saying. With regards to mutation testing: I'm not sure where this Hopk
401.
by haldujai 3y ago
Not sure if you're specifically referring to the drug in this article but osimertinib has been FDA approved for ~8 years and has been part of routine clinical practice for quite a while now. The system is actually really fast at gettin
402.
by haldujai 3y ago
I don’t know much about pharmaceutical pricing or drug discovery to offer an informed opinion as to why it’s so expensive ($300/day) or whether that’s justified. AstraZeneca’s patent expires in 2035 and as a cash cow ($2B in revenue) I
403.
by haldujai 3y ago
The newest thing is to avoid ground level apartments in a city with traffic if you can. I’ve been told brake (or tire) dust is the newest suspect for why young never-smokers are developing lung cancer (combined with certain relatively preva
404.
by haldujai 3y ago
I wasn’t involved in this study but the cancer center I just left was one of the sites for the upfront Lu177 vs chemotherapy trial. Speaking casually with the physician involved recently he said the results weren’t promising thus far. I don
405.
by haldujai 3y ago
Very sober given the costs and %age of patients who didn’t receive adjuvant chemo in the initial trial. Interested to see their detailed results but I’m mildly suspicious this will be AstraZeneca PR buffing underwhelming results.
406.
by haldujai 3y ago
You’re both kinda right, personalized or targeted cancer therapy is definitely an incredibly promising field and the early results in various cancers are promising. Most notably in disseminated disease. Simultaneously, one of the largest cr
407.
by haldujai 3y ago
The good thing is in most people (particularly smokers) it is very slow growing. We also have great non-invasive curative treatment options like stereotactic radiation.
408.
by haldujai 3y ago
The data isn’t published yet (presumably this was shown during the ASCO conference this weekend) but this is a bit misleading and the results seem underwhelming. The DFS numbers are not new and known, the reason this is in the news as it’s
409.
by haldujai 3y ago
This is a great example of why relative risk matters so little when the absolute risk is so low.
410.
by haldujai 3y ago
From [2]: The C.I.A. has repeatedly defended its use of rectal rehydration as legitimate medical practice, rather than punishment. “Medical personnel who administered rectal rehydration did not do so as an interrogation technique or as a
411.
by haldujai 3y ago
1 day a year of a low-wage employee, unknown % of which is malingering vs illness, is a major cost on an employer?
412.
by haldujai 3y ago
> costing the company too much in wasted time and pay If this happens it's not occasional and would be better addressed on a case by case basis. > Blame the few arseholes that ruin everything for the rest of us. In light of the a
413.
by haldujai 3y ago
> My wife is a physician, as are many of our close friends. They nearly all work for private groups, and they mostly have some kind of employer matched plan. My wife’s group just directly contributes up to 13% of her salary to her retire
414.
by haldujai 3y ago
> Did you ask about that? Sometimes if you don't ask, you don't get. I did not. I think I'm so conditioned to being treated poorly by hospitals I just assume I'm going to be taken advantage of but you're probably
415.
by haldujai 3y ago
> Pediatric Emergency Medicine. All in cities large enough to have a children’s hospital, so basically minimum metro populations of 500k or so. Interesting, pediatrics is so underfunded and poorly respected in Canada that I'm genuin
416.
by haldujai 3y ago
I loathed these visits when I had to do primary care. I understand the patient's position and don't hold that against them but can we just decide as a society to let people take occasional sick days and stop wasting everyone&#x2
417.
by haldujai 3y ago
They have it backwards, rich people come to the US for their treatment. It's not a coincidence that places like Mayo/Hopkins/MD Anderson all have buildings named after a gulf country sheikh. Top US institutions are definitely
418.
by haldujai 3y ago
I think you meant to say [beautiful] post treatment livers! They're one of my favourite study types to read although everyone else seems to hate them. MSK joint studies are definitely higher throughput but those are fun too. We would t
419.
by haldujai 3y ago
> When it comes to value, when my wife interviews for a job (she’s a physician) they fly her out and spend a day taking her to see the sights, so they convince here how great the city is. Then they take her out to a fancy dinner and woo
420.
by haldujai 3y ago
> In retrospect, I've concluded that the real problem they faced is they'd built a life dependent on a physician or surgeon's income. They were told they were building a castle, but instead they built a prison. The fact is

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