entee

18 ms·

91.
by entee 6y ago
Important caveat for one of the patients mentioned in the article: “Her telomeres were considerably shorter than those of healthy teenagers, suggesting that her cells were ageing at an accelerated rate.“ Aging is weird. Maybe there’s someth
92.
by entee 6y ago
Entirely possible! Hadn’t heard that critique but makes sense and something to control for.
93.
by entee 6y ago
There are tons of reasons this wouldn’t have happened. Lots of this is speculation but: Seems likely this is a gradient, not a binary thing, so perhaps someone with a beneficial mutation would just live a little longer. There’s not a ton of
94.
by entee 6y ago
There’s a host of evidence that parabiosis (blood transfer from young to old) works well in mice/rats for a variety of aging issues. Some of the more concrete claims that it will transfer to humans are not as well supported to my knowl
95.
by entee 6y ago
Algae and Cyanobacteria tend to be substantially more efficient than whole plants (6-8% [1]). There are some caveats though. Generally the industry has found it hard to grow algae at commercial scale cost-effectively for several reasons inc
96.
by entee 6y ago
As others note it's super complicated with viruses. If you want to track the mutations in real time, check out the Nextstrain project ( https://nextstrain.org/ ). The main person behind it, Trevor Bedford, is also a good
97.
by entee 6y ago
Fair though why do you think nobody is looking? There are several vaccine efforts, some of which are inactivated virus based. https://blogs.sciencemag.org/pipeline/archives/2020/04/23/a-...
98.
by entee 6y ago
It’s my understanding that viruses have a complex fitness function. If you think about it, the ideal virus spreads like crazy but doesn’t make anyone sick. If you make someone sick, you reduce the time they spend in the world so you spread
99.
by entee 6y ago
To point 1, you’re right we don’t know for sure, but past experience with Coronaviruses (4 are endemic plus SARS and MERS) suggests that 0.5-3 years is not unreasonable. Past that the question becomes how much immunity, I.e. even if not com
100.
by entee 6y ago
At the risk of starting a flame war, lvs is mostly correct. These are NOT whole gene deletions, they are nucleotide deletions. Genes are usually longer than 33 nucleotides, by my count the largest deletion he sees. For reference, that’s 11
101.
by entee 6y ago
I think you’re totally right. In addition/corollary, it seems a lot of the things Amazon Basics sells are basically commodities. If you have a million iPad stands, eh, just buy the amazon basics one, it’s probably not crap and the revi
102.
by entee 6y ago
The major question I don’t have a good answer to is, “Why is this different than brick and mortar store brands like Safeway signature?” Surely a part of is is placement, but Safeway could put own brand ketchup at the same level (and I think
103.
by entee 6y ago
By the time it gets to the lab tech, it's unlikely that the virus would be as viable as it is when exiting the host. This would be especially true if the swab is put into some sort of preservation liquid (I don't know for this tes
104.
by entee 6y ago
Note that most of the initial tests required a nasopharyngeal swab which has to go back into your nose several inches. I'm not surprised that the FDA doubts that people would be able to do that reliably on their own given that even tra
105.
by entee 6y ago
Perhaps, though I once broke a 1L bottle of ammonium hydroxide (a strong solution of ammonia) in the lab. We literally couldn’t go in the room for 15 min. That was just 1L of not 100% ammonia, and we had a door where we could get out. Even
106.
by entee 6y ago
I don’t see how that’s a mistake at all from a customer perspective. You’re asking a consumer to buy something very expensive that in the past could do a whole bunch of things like go long distances, but now does less of those things. In ex
107.
by entee 6y ago
Very much so. Would be hard to breathe at any accident site with a leak.
108.
by entee 7y ago
Very few viruses are true aerosol transmitted (measles is), it’s likely COVID is droplet based so coarse masks will help. Even with an N95, true aerosols can make it through, though obviously not 100% transmission (95 means block 95% of 0.3
109.
by entee 7y ago
It’s misleading to say there’s no evidence of smear transmission. Take that choral rehearsal you mention. Could have been that they breathed in droplets, also could have been that a droplet found their way to a shirt, the person touched the
110.
by entee 7y ago
Not entirely sure whether you're kidding, but however mickey mouse it was, it did end up as a precursor to earning a biochemistry PhD at a top ranked university so I guess the joke's on them!
111.
by entee 7y ago
So many problems with this analysis. 1.) main paper cited is from 2006, 2.) article is from 2016 3.) much of the data is older, several plots go to 2014 4.) almost no analysis that looks at long term profile of companies that do this over a
112.
by entee 7y ago
Not sure what CS degrees you're talking about, but having done both a Biochemistry and a CS degree as an undergraduate, your description doesn't comport with what I've seen. I had on average about one lab class a semester as
113.
by entee 7y ago
The issue is that making a mistake here isn't like making a mistake about, say, movie review sentiment analysis. Already there have been a few "I know stats!" posts that didn't do the right controls but still got sent ar
114.
by entee 7y ago
I think you’re missing one of the key parts of the article: be careful. Mass administration of a drug is dangerous. As you mention early in your post, you know what you’re doing, I take you at your word. But a drug with known serious side e
115.
by entee 7y ago
Sorry! Can't fix now :( Thanks for correction! (Worst part: my cousin went to ICL)
116.
by entee 7y ago
No. Very simply, an extreme response is required here. The most recent UCL study demonstrates that given everything we know about the virus, extreme social distancing may not even be enough [1]. Worse, if we are successful, it will look lik
117.
by entee 7y ago
Correct, got my math a little off in haste. Constant gets pretty huge which give massive signal, thanks for the correction :)
118.
by entee 7y ago
Correct! Though making that template isn't that difficult either, you can order the DNA version and generate the RNA from that.
119.
by entee 7y ago
Go for it! Just keep in mind that the benefit there is pretty minimal. Probably not quite zero, but we're talking way less than hand washing. And if you touch your face more as a result of wearing the mask... That's not to say do
120.
by entee 7y ago
One disadvantage to RT-qPCR I forgot to highlight, and an advantage to direct detection ELISAs (and ELISAs in general) is that ELISAs are relatively robust when fully developed. RT-qPCR requires a lot more gear. See pregnancy tests. Sits on

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