There’s a host of evidence that parabiosis (blood transfer from young to old) works well in mice/rats for a variety of aging issues. Some of the more concrete c

There’s a host of evidence that parabiosis (blood transfer from young to old) works well in mice/rats for a variety of aging issues. Some of the more concrete claims that it will transfer to humans are not as well supported to my knowledge, but that doesn’t mean impossible, just not known yet. I would also question some of the strong claims about the hypothalamus as a centrally controlled aging clock, and that DNA methylation is a driver (rather than a marker) of aging. These are big claims, the article supports them poorly. DNA methylation is an on/off signal for genes in the cell and is a subject of active research. As you can imagine it’s been implicated in a large number of biological processes including cancer. I’d be careful messing around with it in a global way. I know of one at least one company (Spring Discovery) that is following some of this work up to find some driver molecules that could have the same effect as parabiosis. If interested in the topic I’d look at the work from the labs mentioned in the article as well as Saul Villeda (former grad student of Wyss-Coray, full disclosure I know him socially) at UCSF. TLDR: This article is a breathless take on active research, clearly the author is excited. There’s reason to keep investigating, but the conclusions in the article are stronger than what the research can say conclusively at the moment. Very early days.