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55 ms
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61.
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by
entee
6y ago
“Easy” is rarely a word I’ve heard associated with crystallography. Hence cryo-em! Easier and faster sample prep.
62.
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by
entee
6y ago
Sharing the OP’s position, and having worked in a biochemical technology development lab in grad school, I don’t think that’s quite right. Structural biology is disproportionately seductive as a data source because we are such visual creatu
63.
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by
entee
6y ago
Any technological or other intervention in the healthcare system must answer the following questions: 1.) Who pays for it? Doctors? Insurance? Patient? 2.) Who benefits from it? How much? Are they the same as the people who pay for it? 3.)
64.
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by
entee
6y ago
As an example of why remote visits are a policy problem, ask yourself why video visits weren’t common before the pandemic even though we’ve had the technology in various forms for literally decades (Skype was founded in 2003 as just one exa
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by
entee
6y ago
Anagenex | ONSITE or REMOTE | San Francisco | Lead ML Engineer, Computational Chemist We are a seed stage biotechnology company building a novel platform for drug discovery focusing on difficult targets. Machine learning has struggled in ea
66.
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by
entee
6y ago
Anagenex | ONSITE or REMOTE | San Francisco | Lead ML Engineer, Computational Chemist We are a seed stage biotechnology company building a novel platform for drug discovery focusing on difficult targets. Machine learning has struggled in ea
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by
entee
6y ago
You’re totally right, and I love those charts. But let’s be clear about what they’re telling us: what we are buying for our employees. It provides no information about how those costs will increase or any “gotcha” features of the plan. Whil
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by
entee
6y ago
First of all thanks for the book, it was a formative read for me as I started out in healthcare data and programming. Second of all, I can’t just upvote, this is so so accurate. The thing to remember in US healthcare is there’s actually not
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by
entee
6y ago
Next gen tech/biotech hybrid companies need support from investors and advisors who understand both pharma AND tech. I know the founder And backers of this incubator personally and they’re the best in the business. This is exactly the
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by
entee
6y ago
We use Rippling, and it's fine as payroll software. I chose it over Gusto because the complete integration between IT and HR is a really great and as far as I can tell unique offering. In addition to payroll I get a "good-enough&q
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by
entee
6y ago
Anagenex | ONSITE or REMOTE | San Francisco | Lead ML Engineer, Computational Chemist We are a seed stage biotechnology company building a novel platform for drug discovery focusing on difficult targets. Machine learning has struggled in ea
72.
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by
entee
6y ago
Hence the mention of some pretty clear historic problems we have to address. I also don’t fully support some of our recent wars, and I don’t pretend to say we’re perfect. We’ve pretty clearly done some bad things even quite recently. What I
73.
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by
entee
6y ago
Because we believe it is the way to maximize individual happiness and that individuals are inherently valuable. To take an individual’s liberty is to violate something sacred that the person has just by being alive. You have to have a very
74.
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by
entee
6y ago
Celine Halioua is an incredibly talented founder. We share investors and have spent a good amount of time together at investor working sessions, and she's building something really cool. This set of resources is quite valuable and prov
75.
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by
entee
6y ago
Anagenex | Onsite | San Francisco | Lead ML Engineer, Computational Chemist We are a seed stage biotechnology company building a novel platform for drug discovery focusing on difficult targets. Machine learning has struggled in early stage
76.
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by
entee
6y ago
$70M is a fraction of what it has taken to get Remdesivir to the point where it is today. The argument that government is paying twice for drugs is usually deeply misleading, though in this case it did sponsor some trials. Usually governmen
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by
entee
6y ago
This all may be true but there’s an issue when the model produces blue eyes when presented with a blurred African American face. I think much of the controversy would be diffused had the authors addressed this directly and used it as a way
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by
entee
6y ago
Agreed on the conflation, and clearly there are many parts of the FDA that need attention. However this article is misleading because it focuses heavily on one teams (basically then Seattle Flu Study) of extremely competent people hamstrung
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by
entee
6y ago
> Interesting to see that the pricing is approximately double that of S3, for what I imagine is not much more than a thin layer on top of it. Haven’t looked carefully, but is there a difference in the guarantees it provides? Might be a p
80.
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by
entee
6y ago
There are different tests out there, many are pretty bad. Some are pretty good, for example Abbott's clears 90% in both specificity and sensitivity. That said, given a low prevalence of the disease, this is actually fairly likely to gi
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by
entee
6y ago
I think on balance you’re right masks probably don’t hurt, and this is a change from my initial views. I don’t think they’re quite as magical as people seem to think. For example if you wear glasses you’ll notice how easy it is to have them
82.
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by
entee
6y ago
I completely agree that the rhetoric around “Science!” has gotten increasingly more toxic. I say this as a trained scientist, we really do at bad job of communicating. This is made worse by a media and a general public that isn’t used to th
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by
entee
6y ago
I think you’re right. I don’t understand the general tendency of assuming malice when a combination of uncertainty about the virus, poor supply chains, and not-very-good underlying data would do just as well. It’s also unclear what “masks”
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by
entee
6y ago
Anagenex | Onsite | San Francisco | Lead ML Engineer, Computational Chemist We are a seed stage biotechnology company building a novel platform for drug discovery focusing on difficult targets. Machine learning has struggled in early stage
85.
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by
entee
6y ago
I wonder if we have gotten to the point that a piece of software like MacOS Is so massive and deals with so many edge cases that it can’t actually be maintained and improved. Every change will have weird gremlins for some odd extension 0.00
86.
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by
entee
6y ago
That’s actually not what I said. I’m saying there were lockdowns in the most important regions (Miami-Dade for example), that people behaved as though there were lockdowns in at risk areas (nursing homes), and that people are still behaving
87.
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by
entee
6y ago
The major flaw in your argument is focusing on an official quarantine order. In practice it seems many of the places you mention have an informal quarantine in place. In Florida Miami-Dade county did have a lockdown though the broader state
88.
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by
entee
6y ago
Nearly 100,000 people have died of COVID19 and there’s good evidence that this is a substantial undercount. All this in a context where we shut down transmission vectors (being indoors, with lots of people). Most estimates I’ve seen suggest
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by
entee
6y ago
Should be noted that a number of people in Gallagher’s unit came forward and raised issues. It’s one of the reasons he was prosecuted in the first place.
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by
entee
6y ago
I agree to a certain extent on your revised assessment framework, but I’m not sure it would work very well in some of the basic sciences. As someone who has gone to college for these things and beyond, I can tell you there’s very little as
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