dm319

50 ms·

541.
by dm319 6y ago
We aren't nearly as in control of our lives as we like to think, and we often construct stories and arcs to explain our paths. Actually, most of what has happened to us, whether we've been successful or not, is down to chance, st
542.
by dm319 6y ago
> You are 0% basic. Have you considered there's a reason nobody listens to Mistabishi?. > > Your spotify was ira-glass-in-your-airpods-manic-pixie-dream-girl bad. Made me laugh!
543.
by dm319 6y ago
Yes, he's definitely not been great. We're talking B- here, not A+. Maybe C++.
544.
by dm319 6y ago
No that has not been apparent. The first lockdown got cases down to very low levels (10s/million/day). It turned around a sky-rocketing increase in cases - it's not like the seasons changed between April and May. The secon
545.
by dm319 6y ago
By full lockdown I mean similar to the first-wave lockdown in the UK. No travelling for non-essential work, only key workers. Vaccination _is_ adapting the immune system, and exactly combats viral evolution by shutting down the transmissio
546.
by dm319 6y ago
I'm sure this is likely. It's quite concerning, as it may mean that we need a full lock-down (as in people not going to work) until we have a majority of the population vaccinated.
547.
by dm319 6y ago
Highly unlikely. You overestimate our ability to genetically edit things and predict what the outcome will be. The virus is mutating at a rate of about one mutation/month - that's fairly standard.
548.
by dm319 6y ago
He's had a lot of criticism, but I don't think he has done too badly. And that's coming from someone who is normally left-leaning, and not a fan of him. There were definite mistakes at the beginning, and a blase attitude re
549.
by dm319 6y ago
Something strange was happening in the UK rates in the last few weeks. Despite a second lockdown, cases in London started increasing again, and areas in 'Tier 3' (highest tier restrictions) also started increasing cases post-lock
550.
by dm319 6y ago
Not sure it's the whole world. US lobbying is something not really seen in a lot of other countries.
551.
by dm319 6y ago
From what I understand the whole reason this happened was that Boeing wanted the new efficient engines without having to call the plane a new model. So they were really asking pilots with no training on the new Max planes to react correctl
552.
by dm319 6y ago
Wow, how about finding something you enjoy / a team you enjoy working with and doing that instead? I mean 40 years is a long time, and what do you do then after? Nothing? Or browse HN all day? Or do a job that you enjoy?
553.
by dm319 6y ago
It exists in varying amounts in different companies and departments. I don't work in tech, but I know there are some departments where I simply will not work because I would become miserable. There are other departments that have a l
554.
by dm319 6y ago
Would this significantly impact on targeted advertising?
555.
by dm319 6y ago
I still prefer tapping numbers into real buttons - it's more reliable for one thing.
556.
by dm319 6y ago
I use free42 on my phone, have been tempted to get DM42 for ages, but not sure I can justify it. It'd be nice to have a little 4 function RPN calculator for my desk that is cheap enough for me to allow it to stay there.
557.
by dm319 6y ago
Good to hear from you, and I really like what you were doing with numworks. Did you ever get past the license issue? To appeal to tinkerers and get a community of hackers enthused it would be preferable to have an open source license. Als
558.
by dm319 6y ago
To keep your market larger? /s Most trials were run in countries where a large number of new cases were expected over the trial period. Government measures in almost all first world countries brought the R rate right down, which is di
559.
by dm319 6y ago
The paper is available [1]. They did a reasonable job - 9% black/african-american and nearly 30% latino (the trial was run in Argentina and Brazil). Subgroup analysis similar efficacy between groups. Around 25% were more than 65. M
560.
by dm319 6y ago
It's a prevalent attitude of successful people who are used to lower ethical standards applied to them and being given priority in their day-to-day life. An extra factor is that premium cars (irrespective of wealth) are sought after b
561.
by dm319 6y ago
Rival Oxford, which took funding from the UK [1], produced a vaccine which was first to be published demonstrating successful efficacy results [2]. [1] https://www.ovg.ox.ac.uk/news/funding-and-manufacturing-boos... [2
562.
by dm319 6y ago
What is particularly interesting is the response in the elderly population, as it's this group that seem most at-risk. The earlier studies were done in a younger population without co-morbidities, but later studies included all-comers
563.
by dm319 6y ago
I'm in the UK, and by the time you've reached a certain age, we've all heard of families torn about by bad driving. The couple who we bought our house from, the mother pulled out in front of two racers just down the road fro
564.
by dm319 6y ago
Some details: Vaccine storage and preparation The Pfizer/BioNTech coronavirus vaccine has the most difficult storage requirements of all the COVID-19 vaccine candidates currently undergoing trials. Currently, it needs to be stored betw
565.
by dm319 6y ago
The pfizer vaccine is mRNA, so when it goes into a cell it will use the translation machinery to convert to protein and that gets presented to the immune system. The Oxford vaccine uses a non-reproductive adenovirus to introduce the RNA in
566.
by dm319 6y ago
I always find it weird that sex gets equated to other negative things like this. Same for TV/film ratings. And yet these days, even kinky sex, is pretty low risk.
567.
by dm319 6y ago
A lot of people are slightly skeptical/worried about the safety here in the UK. These aren't anti-vaxxers. More 'you first'.
568.
by dm319 6y ago
Yes the priorities are the over 80s, any spare slots are being given to the most-at-risk clinical groups (i.e. guessing ITU, A+E, resp and ENT). They reported internally that they administered 'dozens' today, so less than a hundr
569.
by dm319 6y ago
Yes, these were patients attending my clinic for other reasons. At any one time there are obviously several clinics running - I suspect the hospital will announce how many in total have been vaccinated at the end of the day.
570.
by dm319 6y ago
These were patients attending for another reason. It's a large teaching hospital (1250 beds) with many patients attending for outpatients every day, so I'm sure there will be plenty of eligible patients to give the vaccine to.

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