alexholehouse

7 ms·

1.
Dewpoint Therapeutics Launches with $60M for Drugging Condensates(biospace.com)
1 points by alexholehouse 8y ago|0 comments
2.
by alexholehouse 8y ago
This is one in a number of papers exploring how biological phase separation/condensation may have provided favourable microenvironments for early life development. For a nice primer on what biological phase separation is, see this (non
3.
by alexholehouse 8y ago
Right - yeah; I don't know, I had the same thought when I read the commentary (I read the paper first). Nothing in the papers suggests the ability to monitor formation/loss in realtime I don't think? My guess is this is an in
4.
by alexholehouse 8y ago
Yeah agreed (what in vitro means to different people is a whole other conversation :-P), but that sentence makes it pretty clear that by in vitro they mean not in cells (because it says, "and not inside cells"). Agreed, of c
5.
by alexholehouse 8y ago
So it seems like there are two timescales for what 'transient' means in the paper. 1) There are different levels/numbers of i-motifs identified depending on the cell cycle position (highest at G1/S boundary, although thi
6.
by alexholehouse 8y ago
But this is literally the entire point of the this paper. The sentence you just pasted was the the previous state of the art, this paper makes the point that they have now imaged them in cells (using i-motif specific antibodies).
7.
Neuroscientist Ben Barres has died(med.stanford.edu)
95 points by alexholehouse 9y ago|12 comments
8.
by alexholehouse 9y ago
>My take on the not-listening thing -- of course I'm not Aron -- is that if you've heard a faction hector you a lot, and you don't think they're listening to you except maybe to match some of your words into their sta
9.
by alexholehouse 9y ago
Ha! - point extremely well taken, in much the same vein as "I'm not racist, BUT...". I did feel awkward writing it - in this case it was actually meant sincerely. I really wasn't sure if I'd misunderstood. It seemed
10.
by alexholehouse 9y ago
Then, with all due respect (and perhaps I misunderstood), perhaps you should consider a greater degree of open mindedness? If the fact that you disagrees with the first clause in an argument is enough for you to conclude the rest of the dis
11.
by alexholehouse 9y ago
As mentioned in the memo, gendered interests are predicted by exposure to prenatal testosterone – higher levels are associated with a preference for mechanically interesting things and occupations in adulthood. Lower levels are associated
12.
New role in cells suggested for ATP(cen.acs.org)
62 points by alexholehouse 9y ago|17 comments
13.
by alexholehouse 9y ago
So for some context, my work is not directly about evolution, but about how amino acid sequence determines function in the context of unfolded/disordered proteins. That said, here are several at least semi-relevant papers that have in
14.
by alexholehouse 9y ago
Not at all - there's some additional text that provides set-up for the idea of mechanism. Re-reading it now cold, I read it exactly as you (and others) did as well. And I (embarrassingly) am relatively confident I wouldn't have ca
15.
by alexholehouse 9y ago
The thesis won't be publicly available for a while because there is fair amount of (currently) unpublished data that is associated with various collaborations.
16.
by alexholehouse 9y ago
Thank you - categories vs. categorise is a great spot!!! Where are the spelling mistakes? I don't see the missing 'the' in the first sentence? Mechanism here is in the abstract, if that's what you're referring to?
17.
by alexholehouse 9y ago
This is oddly poignant to me. I just (literally a few hours ago) submitted my PhD thesis on (broadly) the biophysics of emergent phenomena. People don't usually read theses cover to cover, with good reason, but I included one short par
18.
by alexholehouse 10y ago
Many of these proteins are intrinsically disordered proteins (IDPs), meaning they don't actually have a set 3D structure, but instead existing in a kind of 'cloud' (ensemble) of interconverting conformations. A consequence of
19.
by alexholehouse 10y ago
Great to see this in the NYT. I'm working with Thomas (who, in addition to being a truly exceptional scientists is a really great guy) on understanding the underlying biophysics of how these disordered proteins facilitate stress prot
20.
The Shape-Shifting Army Inside Your Cells(quantamagazine.org)
1 points by alexholehouse 10y ago|0 comments
21.
by alexholehouse 10y ago
One thought: FitBit's customer service with me has been nothing but exceptional from start to finish, and is the reason I have bought several for family members. I would hope that FitBit would recognize the loyalty they create based
22.
by alexholehouse 10y ago
Short chain fatty acids can be things like acetic acid, propionic acid, butyric acid. The fermentation process takes in fiber and puts out these guys, so while fiber isn't an SCFA polymer, I don't think this statement is inaccura
23.
by alexholehouse 10y ago
Nothing, because I literally don't have an account.
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by alexholehouse 10y ago
So, interestingly, it had me logged in to reddit, but I don't actually have a reddit account at all. Thoughts?
25.
by alexholehouse 10y ago
I wrote up the course a few years ago for easy reference. I need to update these notes it as I have about a year's worth of (minor) typos that people have pointed out [which is hugely appreciated], but in general they seem well receive
26.
by alexholehouse 10y ago
So I've always had this (entirely crackpot) idea that the Tunguska Event is actually the place and time in space/history that you'd want to test the first time-travel device to. From a 'test system' design perspecti
27.
TraffickCam – stop sex trafficking with image recognition(traffickcam.com)
5 points by alexholehouse 10y ago|5 comments
28.
by alexholehouse 10y ago
Reproducible is a major issue across science in general, but the difference is there's no reason why one shouldn't be able to easily re-run a defined analysis on a more recently updated data set to ask if conclusions drawn previou
29.
by alexholehouse 10y ago
To be fair, this doesn't have to have originated via animal-to-animal infection, but could be an example of sporadic CWD. As far as I know, sporadic CWD is relatively uncommon, but given CWD is caused by the PrP protein, and there are
30.
Fixing the internet for realtime applications (1 of 2)(engineering.riotgames.com)
1 points by alexholehouse 11y ago|0 comments

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