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The brain may be about to have its Ozempic moment
- awestroke 3mo agoTitle implies people will flock to a pill that makes them shed gray matter
- bayarearefugee 3mo ago[flagged]
- amarcheschi 3mo agoI like my brain fatty /s
- make3 3mo agoIt's probably the default clickbait title for any article about a new drug.
- projektfu 3mo agohttps://old.reddit.com/r/ExtraFabulousComics/comments/1iqsqdz/unlimitless_potential/ https://old.reddit.com/r/ExtraFabulousComics/comments/1iqsqd...
- coffeefirst 3mo agoYeah, I really dislike this “Thing is has its Other Thing Moment.” For starters, I what the hell does this mean? But it’s also a style of reporting that treats the attention cycle as the thing that must be covered rather than the thing itself.
- parineum 3mo ago> For starters, I what the hell does this mean? Well, there's a whole bunch of words after the title that help explain that.
- Rzor 3mo agohttps://archive.is/WoHuY https://archive.is/WoHuY
- whyleyc 3mo agohttps://archive.is/WoHuY https://archive.is/WoHuY
- kyriakos 3mo agogeneral question: is there an alternative to archive.is ? it seems to be blocked in my country.
- devindotcom 3mo agothere are variations but some are shady... archive.ph, archive.today, etc. there's probably a central list somewhere.
- pygy_ 3mo agoI thought they were alternative domains for the same service... Regardless, I'm stuck in captcha hell whenever I try to reach them (I've tried switching browsers and DNS servers, no luck).
- devindotcom 3mo agooh perhaps you're right. i thought they were clones, not alternative domains. i had that captcha issue as well, it disappeared through no action of my own. hope the same for you.
- throw-the-towel 3mo agoarchive.today and archive.fo is literally the same service.
- sumek83 3mo agohttp://archiveiya74codqgiixo33q62qlrqtkgmcitqx5u2oeqnmn5bpcbiyd.onion/ http://archiveiya74codqgiixo33q62qlrqtkgmcitqx5u2oeqnmn5bpcb... via tor browser
- tkfoss 3mo agocheck URL list on its wikipedia page.
- Liftyee 3mo agoSleep is Lindy... obesity and constant wakefulness are not. The sad fact is that people will be pressured into taking this. E: Lindy was probably the wrong term. But still, it's like Chesterton's fence. We are far from fully understanding human biology... and deleting sleep will lead to unknown effects. All power to those who try, I guess.
- andybak 3mo agoIs "Lindy" a typo or have I missed another linguistic innovation?
- gottorf 3mo agoAnother linguistic innovation[0] -- the idea that things that have been around for a long time are more likely to persist for another long time. [0]: https://en.wikipedia.org/wiki/Lindy_effect https://en.wikipedia.org/wiki/Lindy_effect
- shimman 3mo agoThis feels like a stupid heuristic to use if applied to biological forces.
- ternaryoperator 3mo agoIn the definition of it, living things are specifically excluded.
- bryanrasmussen 3mo agoit seems however some things that are not excluded are just one step removed from biological entities, hence >comedians do not have a fixed amount of comedic material to spread over TV appearances, but rather, the more appearances they make, the more future appearances they are predicted to make sure, but earlier it says that it does not apply to humans because the Lindy effect would imply that a 100 year old would have more life left than an 11 year old, which is counterintuitive, but the example given above would imply George Burns had more television appearances left to do at the age of 99 than Macaulay Culkin at the age of 9, which is just a layer of abstraction laid over the biological age property.
- nemomarx 3mo agoI feel like I'd want the opposite of this - something that mimics the cleaning process of sleep that you could use in the afternoon for a nap or etc.
- strictnein 3mo agoBy mimic do you mean it does the cleaning process or just that you feel like it did? If it was the former, that would be very interesting.
- hamdingers 3mo agoThe latter is how caffeine works. Blocks adenosine receptors so you don't feel tired even though you are.
- Gooblebrai 3mo agoIf you don't feel tired, are you really? I'm curious what are the objective metrics to determine someone is tired
- usui 3mo agoIsn't the answer yes if people still die from overwork despite being caffeined up?
- odo1242 3mo agoCaffeine doesn't actually do any of the things sleep does to your brain. If you drink coffee during a late night, you won't feel as tired, but your brain performs worse, your reflexes are slower, you're less likely to remember things, etc. It's like painting over a rusted car instead of properly maintaining it, basically.
- binary132 3mo agoI think GP was just making a point about the fact that “tired” is a subjective experience, like pain. Arguably, if you’re on pain medication, you’re not in pain, even if your body is sending pain signals that your brain just isn’t receiving or paying attention to.
- hoppp 3mo agoIt sounds to me like something that's quite dangerious. Maybe it helps people with narcolepsy but maybe it will be another thing people abuse like amphetamines?
- subscribed 3mo agoModafinil is available for ages, acts close to this (it's mentioned in the article), and I don't hear of people abusing it.
- projektfu 3mo agoIt gets abused by people who just want to stay awake, but not in the sense of being a party drug. For example, by students, drivers, security officers, and politicians.
- subscribed 3mo agoIt promotes wakefulness and (allegedly) concentration. It's not a magic or amphetamines, not sure how is that an "abuse"? Do people drinking coffee in the morning *abuse* it?
- projektfu 3mo agoCoffee isn't a Schedule IV controlled substance in the US. I'm using a pretty strict definition of abuse, which is just using medication outside of its indications, or when it isn't prescribed to you.
- ShinyLeftPad 3mo agoI don't know of anyone using it in the first place...
- subscribed 3mo agoThat's okay, they're elsewhere.
- OutOfHere 3mo agoPrevious post: https://news.ycombinator.com/item?id=49206165 https://news.ycombinator.com/item?id=49206165
- egypturnash 3mo agoConsider: Beggars in Spain. https://www.goodreads.com/book/show/68333.Beggars_in_Spain https://www.goodreads.com/book/show/68333.Beggars_in_Spain
- danipark 3mo agoThis is what I exactly thought
- croisillon 3mo agoThe brain may be about to have its Algernon moment FTFY
- LogicFailsMe 3mo agoDon't forget the flowers.
- petercooper 3mo agoNot to take away from the broader point, but modafinil is lumped in with methylphenidate as a stimulant that "increase[s] the activity of neurotransmitters such as dopamine and norepinephrine". Modafinil does also stimulate the orexin system and is part of why it's so effective for wakefulness and not as a stimulant in the medium/long-term.
- Gooblebrai 3mo agoWhat has anything in this article to do with Ozempic? Is mentioned in the title once and never again. Engagement bait?
- matt_heimer 3mo agoOzempic == GLP-1 which the first visible paragraph is discussing.
- RIMR 3mo agoYour brain is gonna lose so much weight!
- FeteCommuniste 3mo agoNeural minimalism, the newest health trend coming to a social network near you.
- _diyar 3mo agoOzempic is the poster boy for peptides.
- projektfu 3mo ago"Hunger and sleep, argues Dan Skovronsky, the firm’s chief scientific officer, are both 'master homeostasis mechanisms'—systems that keep the body in balance. When they misbehave, illness follows. That, he says, helps explain why incretins, the hormone family behind GLP-1, proved so broadly useful. Hence why orexins could be just as important." Also, orexins are peptides, like semaglutide (Ozempic), although in a different family.
- margorczynski 3mo agoIsn't the problem with lack of sleep (and what causes death with enough deprivation) oxydation that happens in the gut and spreads to the organs? If I'm not mistaken there was an experiment using fruit flies where they fed them antioxidants and that made them not die from lack of sleep.
- midtake 3mo agoThe article is about modulating orexins in the brain. Orexin receptor agonism was thought to be a mechanism of modafinil/armodafinil but this isn't mentioned anywhere in the article. Modafinil is mentioned as a mere stimulant. It sort of makes me want to dismiss the article as manufactured hype for a new class of modafinil successors.
- sublinear 3mo agoYup, and even the title alone gives it away.
- mannyv 3mo agoFTA Modafinil et al work at a different level than these peptides do.
- LandStander 3mo agoFTA Modafinil Free Trade Agreement Modafinil?
- sameerds 3mo agoFrom The Article
- cman1444 3mo ago>Orexin receptor agonism was thought to be a mechanism of modafinil/armodafinil. The article seems to imply this is not the case. Do you have a source that says that Orexin agonism is the mechanism of action for modafinil?
- barapa 3mo agoEvery conceivable thing 'may be about to' happen.
- wesselbindt 3mo agoLiterally everything except the media writing non-sensationalist headlines about science.
- Melatonic 3mo agoI think the real question with Ozempic is.....why are so many people's bodies not producing enough natural GLP-1 in the first place? Ozempic is for sure a miracle for some who really need it but for many I think they would be better off by solving that problem at the source (likely gut bacteria based and consuming a better mix of prebiotic fibers). Increase your natural levels of GLP-1
- thinkingtoilet 3mo agoMillions of years of evolution and selection ending up at humans needing one food supply and lifestyle while modern life is basically the opposite. Endless calories. Sugar and meat everywhere. Our bodies are did not evolve for modern life. That's why.
- cpursley 3mo agoMeat? Errrr, did you mean to write refined white carbs? Those obsidian spear points were not for shucking corn…
- teiferer 3mo ago> I think the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place? That's pretty easy: The last centuries (or decades, mostly) have provided an asymmetry in nutrition systems. Modern food engineering has optimized most of what people eat to have them crave more instead of being mainly filling. There is little to counter that, and GLP-1 is a way to do that. Another way is will power. Yet another is fixing what and how you eat (and how you exercise, but that'a a different topic).
- Melatonic 3mo agoExactly. And that last one is the most important for long term results. Plus it's not like you couldn't combine a GLP-1 drug with great diet and exercise
- 3mo ago
- Fraterkes 3mo agoAs an aside, are there any habitual modafinil takers here? I had a period in college where I took it very rarely when I had to cram. Worked pretty well.
- d2kx 3mo agoModafinil has been a lifesaver for me for over a decade, but always great to have more options for medium ADHD.
- Melatonic 3mo agoIsn't it technically off label for ADHD ?
- semiquaver 3mo ago> Orexins are made by a small number of neurons in the hypothalamus, a brain region tucked behind the eyes. I didn’t know that “neurons” themselves could make peptides, or anything really. Is this accurate terminology or a shorthand?
- JumpCrisscross 3mo ago> didn’t know that “neurons” themselves could make peptides Neurons synthesize proteins [1]. (I think glia do the heavy lifting.) [1] https://brain.mpg.de/164308/protein-supply-in-long-nerves-how-do-neurons-do-it https://brain.mpg.de/164308/protein-supply-in-long-nerves-ho...
- malfist 3mo agoAccording to Wikipedia its accurate. Learn something new everyday
- FeteCommuniste 3mo ago> Orexins are only produced by a small cluster of neurons in the hypothalamus, a brain region located roughly behind the eyes and between the ears. https://sleep.hms.harvard.edu/education-training/public-education/sleep-and-health-education-program/sleep-health-education-4 https://sleep.hms.harvard.edu/education-training/public-educ...
- IsTom 3mo agoWhy couldn't they, if they've got DNA and ribosomes?
- daquisu 3mo agoRelated: - Ozempic For Sleep https://www.isaak.net/sleepless/ https://www.isaak.net/sleepless/ (November 2024) It is the same author from https://news.ycombinator.com/item?id=41742432 https://news.ycombinator.com/item?id=41742432 He recently founded https://capable.com https://capable.com, also related
- MarkusQ 3mo agoFor a minute I thought they'd found a cure for fatheads.
- deadbabe 3mo agoImagine a cure for sleep, it would be a big productivity gain for society if people could work way more hours or spend more hours consuming every day and not even be tired.
- pstuart 3mo agoI just want something that increases deep sleep -- I think just tricking the brain to control sleep is probably not enough -- it's likely a two way street.
- cman1444 3mo agoIsn't that what the antagonists mentioned in the article are for?
- creatonez 3mo ago"Ozempic moment" seems like a manufactured buzzword in this context. A new modafinil variant is nothing like Ozempic. The thing that was actually interesting about Ozempic wasn't its windfall profits, it was the fact that it is a new class of drugs, and the fact that it's able to rather directly target a habit without wreaking havoc on the body. Part of the article mentions there is hope it may be useful for depression, ADHD, and addiction, but whether any of this is actually actually effective is up in the air. Lots of things are in "pharmaceutical companies hope it can treat mental illness" status... but trying to cast an image of being on the verge of a breakthrough is big pharma's whole marketing.
- 486sx33 3mo ago[dead]