3 ms·
Guy in his basement creates a drug to treat Alzheimer's disease using AI
- mikelitoris 4mo agoHow did LLMs not immediately shut down for “biosensitive” prompt or whatever bs they build into them nowadays?
- DonsDiscountGas 4mo agoOpus doesn't do that (at least it never has to me). I'm pretty sure codex doesn't either. It's just Fable
- binyu 4mo agoThat behavior was only observed with the short lived Fable preview, Opus and other models do not seem to pose such limitation.
- hhh 4mo agoThey still have biology safeguards.
- binyu 4mo agoCan you provide an example or a reproducible way to trigger it?
- mikelitoris 4mo agoI feel like if you asked it how to make nerve gas or something that would trigger it. But don’t do that.
- hhh 4mo agoSibling comment by dr. mikelitoris would be a good way
- microgpt 4mo agoBecause he only programmed robots to move A to B and didn't actually do any biology with AI
- CPLX 4mo agoThat does not seem to be an accurate description of what has happened here. What it looks like is someone with significant biochemical experience and a Harvard PhD has created some kind of drug or chemical that he thinks will be effective for treating Alzheimer's, and that he mentions using Claude Code to help him program some of the complex chemical engineering machines that he used along the way.
- microgpt 4mo agoShush, you'll pop the bubble
- ido 4mo agoAny subject matter experts care to chime in with your gut feeling about where this sits in the "promising potential treatment" to "AI psychosis" spectrum?
- Avicebron 4mo agoIt's closer right now to interesting hobby project from a guy who's trained in chemistry, like a guy who's a mechanic keeping a project car. Maybe he publishes and it goes somewhere, I have a feeling getting approval for trials will be challenging with his setup as it is now. I do like the "do chemistry the old fashion way" ethos though. I wish he added a blurb about why he's doing it this way
- cucumber3732842 4mo ago>Maybe he publishes and it goes somewhere, I have a feeling getting approval for trials will be challenging with his setup as it is now. Yeah, drug development is one of those things where practically the only way to make it to production is to let a big incumbent with a big enough war chest to drag it across the finish line buy it.
- skeledrew 4mo agoIf it isn't a potentially big money-maker said big incumbent won't touch it though. Will more likely try to shut it down especially if it overlaps with any of their more ludicrous offerings. And given the properties that this has (easy to manufacture, stable, soluble, low/no toxicity, etc) it's ripe for a shutdown because it'd make AD treatments far too cheap.
- CoastalCoder 4mo agoAny reason he couldn't try advancing it somewhere like China or India, which (I assume) are less vulnerable to that kind of interference?
- 4mo ago
- comboy 4mo agoGuy says he created a drug to treat Alzheimer's disease. Huge difference.
- cristyansv 4mo ago> All of the in vitro screening was performed by an OpenTrons OT-2 liquid-handling robot programmed by Claude Code. Meanwhile, LLMs (mainly ChatGPT Pro) were deeply integrated into virtually every step of the discovery process - I wouldn’t have been able to complete this project without them
- jorisw 4mo agoFor those without Twitter accounts https://xcancel.com/DouglasYaoDY/status/2070904914050797582 https://xcancel.com/DouglasYaoDY/status/2070904914050797582
- WarmWash 4mo agoPainfully editorialized headline. He used AI to program robot arms.
- throw310822 4mo ago"Meanwhile, LLMs (mainly ChatGPT Pro) were deeply integrated into virtually every step of the discovery process - I wouldn’t have been able to complete this project without them"
- amelius 4mo agoWhat does the guy's basement have to do with it? We live in the internet age, we can do anything anywhere. Was there not any other more relevant information to fluff up the headline? By the way, why are we still using twitter?
- deleted 4mo ago[deleted]
- thunky 4mo ago> What does the guy's basement have to do with it? Nothing, because per the post he actually did it in his garage.
- jqpabc123 4mo agoWith help of AI, i developed a universal cure for all disease --- strychnine. However, it does seem to have a few undesirable side effects.
- negergreger 4mo ago[dead]
- ChrisArchitect 4mo agoLink to the overview which is similar to the Tweet text: https://pacepharmaceuticals.com/overview https://pacepharmaceuticals.com/overview
- gus_massa 4mo agoI know too litle biology to be sure this make sense, but I've seen too many crackpots in math and phisics recently... I studied some chemistry. The photo of the lab is interesting. It looks real (not AI generated). It has a few vertical condensers and separatory funnel. The vertical connections make sense, but the whole setup makes no sense, like a display of cool equipment. My question is: Why one of the condensers is green?!?! > the development of PAC-832 was catalyzed by various modern technologies, most notably liquid-handling robotics Is there a photo of the robot? The photo only shows 1990 equipment.
- Haven880 4mo agoMany drugs show promising results. When his pass the first double blind test even if with 5% efficacy, let me know. Otherwise, AI slop.