11 ms·
Anti-aging injection regrows knee cartilage and prevents arthritis
https://www.science.org/doi/10.1126/science.adx6649 https://www.science.org/doi/10.1126/science.adx6649
https://www.science.org/action/downloadSupplement?doi=10.1126%2Fscience.adx6649&file=science.adx6649_sm.pdf https://www.science.org/action/downloadSupplement?doi=10.112...
- AlexDragusin 10mo agoHold your humans: in mice!
- 1970-01-01 10mo agoAt this rate we're going to have mice outliving humans by 2100
- JumpCrisscross 10mo ago“A pill-based version of the same therapy is already being tested in clinical trials aimed at treating muscle weakness associated with aging.”
- gilbetron 9mo agoJust think of mice as the staging environment for production humans.
- nappy-doo 10mo agoAs I've gotten older, my knees have been the main signal letting me know. I tore my meniscus years ago. This is exciting news for people like me.
- fallinghawks 10mo agoThe joint at the base of my thumb started telling me it's 60 years old. I stopped being able to open jars easily last year and would like to get my grip strength back.
- jMyles 10mo ago> The joint at the base of my thumb started telling me it's 60 years old This is my biggest apprehension. I've become quite a good guitarist, and I know that can't last forever. Getting my accomplishments in while I can.
- jacquesm 10mo agoYou better. I have an uncle who was a very accomplished pianist and who can't play anymore due to arthritis. Play the paint off it while you can.
- marbro 10mo ago[dead]
- fallinghawks 10mo agoIronically, last year i decided to relearn piano after some 40 years. Learned one piece (a pretty good one, fortunately) and a once a day play triggered it. So. It's more like once every 2-3 weeks now, not long enough to forget, but long enough to keep the thumb feeling all right.
- circlefavshape 10mo agoYour accomplishments? For me playing music is for joy, not for status
- Brian_K_White 10mo ago1: They didn't say anything about status. 2: Developing a capacity or facility is an accomplishment regardless what purpose it's put to. Trying to tell someone they don't have the right attitude based on something they didn't even say was an interesting way to profess joy.
- jMyles 10mo agoMy first bluegrass record: https://justinholmes.bandcamp.com/album/vowel-sounds https://justinholmes.bandcamp.com/album/vowel-sounds Second record in progress: https://justinholmes.bandcamp.com/album/4masks https://justinholmes.bandcamp.com/album/4masks
- abrookewood 10mo agoI've torn mine as well and am yet to get it repaired. Did you get surgery? Anything working for you?
- RealityVoid 10mo agoI got surgery about 8 years ago, after 10 years of on/off knee pain that I ignored. I had locking in the knee so I needed to so something so I could walk. Surgery was fine, they opened me up and my meniscus was all stringy as if you cracked an egg in boiling water, so no fixing it and they cut off 50% of my meniscus. I recovered quite easily, stupidly did not do any formal physio but proceeded to do mostly moderately heavy lifting with some light running and cycling (very light cardio for the runners around, but still something compared to couch potatoes). Since about 2 years I have pain and a pressure in the knee, not very intense pain but more unsettling. Pain also seems to show up after some sort of activity threshold and the effort accumulates. I eventually took an MRI about a month ago, I have first to second degree condroathy. A couple of physio sessions seemed to help but I need to take the time to do a full physio cycle. I can't wait for cartilage Regen tech. It's very nice being physically active. Worst case, I use it until I can't anymore, do a knee replacement and after that fails hop on one leg as a pirate. My hope to pull another 15 years of functional use out of it, enough to do fun activities with my son.
- giardini 10mo agoEvery son dreams that his Dad has a little bit of pirate! Congrats!
- weeksie 10mo agoin mice
- Volundr 10mo agoAlways a good call out, but also: > Human knee tissue collected during joint replacement surgeries also responded positively to the treatment. These samples, which include both the joint’s supporting extracellular scaffolding, or matrix, and cartilage-producing chondrocyte cells, began forming new cartilage that functioned normally.
- donglong 10mo agolet me be excited for things!
- gilbetron 9mo agoJust think of mice as the staging environment for production humans.
- deadbabe 10mo agoCartilage is really the final frontier of health. If it wasn’t for joints going bad, people could stay very active and fit pretty much all their life, with consistent exercise and healthy weight.
- bitwize 10mo agoI'd say spinal and optic nerve regeneration is more "final" than cartilage.
- deadbabe 10mo agoWell yea but not in terms of the amount of lives that will be improved.
- fuzztester 9mo agoAlzheimer's and similar, matter a lot too. Brain controls body.
- stacktrust 10mo ago> Osteoarthritis occurs when a joint is stressed by aging, injury or obesity. The chondrocytes begin to release pro-inflammatory molecules and to break down collagen, which is the primary structural protein of cartilage. When collagen is lost, the cartilage thins and softens; the accompanying inflammation causes the joint swelling and pain that are hallmarks of the disease. Collagen synthesis in the human body can be aided by hydrolyzed collagen, Vitamin C, zinc and copper.
- rixed 10mo agoEvidence seems to be lacking though. Do you have any specific source in mind?
- aeonik 10mo agoThere's very good evidence coming out of UC Davis. they have MRIs, decent experimental evidence, and biochemical explanations. They have published quite a few papers over the years. You can start here, https://pmc.ncbi.nlm.nih.gov/articles/PMC9267994/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9267994/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5183725/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5183725/ Look up Keith Baar.
- asterix99 10mo agoKeith Baar's videos on YT have helped me a lot; both for treating my knee pain and for increasing overall muscle strength. The videos tell you how to heal or strengthen your tendons, ligaments, and muscles.
- fc417fc802 10mo agoI found that second link interesting although it raised the question of why gelatin versus amino acids in general. However neither link seems to have anything to do with UC Davis or biochemical mechanisms related to collagen supplementation. I realize that it probably wasn't your intent but the mismatch leaves me feeling vaguely as though you tried to deceive me there.
- shepik 10mo agooh, what a time to be a mouse!
- JimmyBuckets 10mo agoTop comment my whiskered friend.
- Volundr 10mo agoLots of folks are pointing this out, but it's not like there isn't evidence to suggest this will also apply to humans. > Human knee tissue collected during joint replacement surgeries also responded positively to the treatment. These samples, which include both the joint’s supporting extracellular scaffolding, or matrix, and cartilage-producing chondrocyte cells, began forming new cartilage that functioned normally.
- layer8 10mo agoToo bad that as a mouse you die after two years tops.
- NedF 10mo ago[dead]
- giardini 10mo agoThey don't say what is injected, calling it only a "gerozyme inhibitor". Original article appears to be: https://www.science.org/doi/10.1126/science.adx6649 https://www.science.org/doi/10.1126/science.adx6649 Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration Mamta Singla https://orcid.org/0000-0002-6408-1167 https://orcid.org/0000-0002-6408-1167, Yu Xin Wang https://orcid.org/0000-0001-8440-9388 https://orcid.org/0000-0001-8440-9388, Elena Monti https://orcid.org/0000-0002-3767-0855 https://orcid.org/0000-0002-3767-0855, Yudhishtar Bedi https://orcid.org/0000-0002-1213-4116 https://orcid.org/0000-0002-1213-4116, [...] , and Nidhi Bhutani https://orcid.org/0000-0002-7494-5870 https://orcid.org/0000-0002-7494-5870 FTFA: "Both systemic and local inhibition of 15-PGDH with a small molecule inhibitor (PGDHi) led to regeneration of articular cartilage and reduction in OA-associated pain." "PGDHi" is a name for both the process "15-hydroxyprostaglandin dehydrogenase inhibition" and any inhibitor. This link(a PDF file) shows PGDHi's are powerful stuff: https://www.biorxiv.org/content/biorxiv/early/2025/04/17/2025.04.11.648417.full.pdf https://www.biorxiv.org/content/biorxiv/early/2025/04/17/202... "PGDHi" could be prostaglandin-E2 (dinoprostone): https://en.wikipedia.org/wiki/Prostaglandin_E2 https://en.wikipedia.org/wiki/Prostaglandin_E2 which was used in: https://med.stanford.edu/news/all-news/2025/06/muscle-aging.html https://med.stanford.edu/news/all-news/2025/06/muscle-aging....
- ck2 10mo agoJAK-STAT inhibitors also downregulate 15PGDH, and in humans they are just insanely expensive in the USA because of drug patents
- mannyv 10mo agoKnee replacement surgeons should be worried. Both my father and FIL had their knees replaced.
- kachapopopow 10mo agoafaik surgeons are able to perform quite a few types of surgeries, obviously the ones working on brains more advanced than ones working on knees it's probably only a few years to transition to a different type of category.
- bitwize 10mo agoI'd like to think orthopedists would rather be overjoyed at this. My wife had her knee and hip done by a cracking orthopedist, and his primary concern was her quality of life. He even went to the state physicians' board to argue that her hip surgery should be considered necessary rather than elective for purposes of COVID restrictions, so that we could get it done months before it was originally scheduled.
- JumpCrisscross 10mo agoPaper: https://www.science.org/doi/10.1126/science.adx6649 https://www.science.org/doi/10.1126/science.adx6649
- amluto 10mo agoThe supplementary material is freely available here: https://www.science.org/action/downloadSupplement?doi=10.1126%2Fscience.adx6649&file=science.adx6649_sm.pdf https://www.science.org/action/downloadSupplement?doi=10.112... It identifies the compound used as SW033291. Searching for it on clinicaltrials.gov gives no hits.
- ldayley 10mo agoIt does , however, provide the ApexBio catalog number A8709, which is this 15-PGDH inhibitor: https://www.apexbt.com/sw033291.html https://www.apexbt.com/sw033291.html
- JumpCrisscross 10mo agoWhat is the relation between 15-PGDH and NAD+ [1]? [1] https://en.wikipedia.org/wiki/HPGD https://en.wikipedia.org/wiki/HPGD
- ashepp 10mo agoCould the same be applied to arthritic ankles?
- pretzellogician 10mo agoAlmost certainly. Ankles also rely upon hyaline cartilage (as opposed to fibrocartilage). I found this out when I had microfracture surgery for a bad ankle injury. Looking forward to this therapy. My fibrocartilage is wearing out!
- jamiek88 10mo agoHere for the same question! Broke my left ankle three times as a football (soccer) playing youth who cared not for rehab! Now stuck with limited range of monitor and arthritis in my foot / ankle.
- mettamage 10mo agoDoes anyone have any idea if you have arthritis what you can do to manage the symptoms? I figure there are some people here that researched it relatively well.
- seabrookmx 10mo agoI think it really depends on your age and underlying cause. Everyone with it I've ever talked to said staying moving is important: "motion is lotion." My elderly family use lots of anti-inflammatory drugs (NSAIDS) and one of them is on Prednisone. Two of my friends with rheumatoid arthritis (only in their 30's) are on an injectable immunotherapies (DMARDs) that have been life changing for them. Disclaimer: not a doctor, just have lots of sore friends/family and an interest in this stuff since I have a torn ACL and fear the future.
- microtherion 10mo agoI've had arthrosis in both knees for several years (due to a combination of youthful sports injuries and overweight). A few years ago I saw a knee specialist who predicted I was due for knee replacement sometime soon. On the advice of a massage therapist I instead started a habit of using a home cycling machine for half an hour each morning. So far, it has worked wonders for me, and I hope I can hold on for a decade more, by which time the injection mentioned in the article might be ready for humans.
- loeg 10mo agoDiclofenac (voltaren) is a topical NSAID that can be useful for managing symptoms. Over the counter in the US.
- nosefurhairdo 10mo agoArthritis is a general term; need narrow down for useful advice on managing symptoms. Two most common types are osteoarthritis (wear-and-tear associated with aging and/or injuries) and rheumatoid arthritis (autoimmune). I only know about age-related knee osteoarthritis to try to help my mom manage her symptoms, so I'll share my understanding of treating that. High ROI, low cost: - weight management. Extra lbs are extra stress on the knees, plus I suspect chronic inflammation associated with being overweight can exacerbate arthritis independent of mechanical stress. - exercise, specifically low impact cardio and any pain-free strength/hypertrophy work targeting the musculature around the knees (mainly quads). Variable ROI, low cost: - NSAIDs, specifically topical to focus on treatment area and reduce impact on GI system/kidneys. - curcumin, mixed evidence but some people report benefits. Variable ROI, high cost: - PRP injections. Apparently the quality on these varies dramatically by provider. Would recommend doing research and comparing multiple providers if possible. - Knee replacement. Far from a panacea; you'll lose range of motion forever, plus plenty of other trade-offs. Most people recommend putting this off for as long as possible. Also interesting is low dose radiation treatment for knee OA. More affordable than other procedures and has some promising research. Not much else on the novel treatment front that I've found. Curious if anyone thinks I've missed anything worthwhile.
- linsomniac 10mo agoI have had fairly serious arthritis in my hips for close to a decade now. Cortizone shots directly into the joint have helped the worst of the flare-ups (limping on my way into the shot, having 0 pain walking out of it, lasting a year). 5+ years ago when I was looking for another injection, my PCP said "Well, time for a hip replacement." Now, for reasons I don't understand I think he was being way premature on that (everyone I'd talked to prior to that had said I should wait as long as I can, and it'd been 2+ years since my last shot). But I'd pretty much accepted that hip pain was just a part of my life, (especially in the morning) picking something off the floor was painful, just walking and in particular walking stairs was just a little painful. A few weeks ago I tried some stretches I saw on Youtube shorts. Like a minute a day. It's like I've got new hips. I've never been a very "compliant patient" when it comes to stretching, but that was mostly because I saw no benefits from it. But this one stretch was like a miracle!
- throwaway7783 10mo agoPlease share which stretches helped you.
- SilentM68 10mo agoThese may not be the same as the one suggested above, but when I fell back in early 2025, my lower back, discs, spine got wrecked. I was sent to Physical therapy and was giving exercises similar to these which helped me, may help you. Keep in mind that it is not a cure... https://www.youtube.com/watch?v=0wAw1-1MHa4 https://www.youtube.com/watch?v=0wAw1-1MHa4
- linsomniac 10mo agoThese are the ones: https://www.youtube.com/shorts/2gS8RYc9lus https://www.youtube.com/shorts/2gS8RYc9lus "Frog Mobility" -- Get on hands and knees, spread knees but keep your feet closer together, rock back towards your heels and forward. "Frog Cat/Cow" -- Same position as above, but tilt your pelvis; curve your back up then down. "Tactical Frog" -- I haven't done this one yet, but it is frog mobility but with each rocking forward twist one of your feet up into the air; IOW rock back then as you rock forward keep one knee locked so that your calf/foot stays in the same relative position as you move forward.
- John7878781 10mo agoIn some contexts (e.g., pancreas), 15-PGDH inhibition can promote tumor growth by increasing specific signaling.
- fcpk 10mo agoYeah, a lot of healing mechanisms are also behind many tumor/cancer factors. There's a lot of reasons behind aging phenomenons, and a lot are self protective. It's not given all of the aging is intended and can't be reversed, but a lot of it is there for biological reasons.
- 8f2ab37a-ed6c 10mo agoI would love this for some of my finger joints beat up from decades of typing.
- elorant 10mo agoHave you tried mechanical keyboards? They were a life saver for me. I can type more than 100k keystrokes/day without any pain whatsoever.
- 8f2ab37a-ed6c 10mo agoYep. On a keyboard with 8 thumb cluster keys per side, and custom 35g switches to lower the force needed to actuate, that helped a lot, but still not enough to be pain-free. Unfortunately once the damage is done on certain joints you can only do so much short of not using those fingers at all. 30 years of hammering keys pretty hard eventually catch up to you.
- yep31 10mo agoYou should try 20g springs, they are really good for typing. I also removed the keycaps and replaced them with small pieces of band-aid on top of the switch stems which also helped. Also dictating plain text like comments and typing only for correcting errors in dictation and for short actions is better. It's easier to press a button rather than say a lengthy command, because vocal cords can also be damaged by speaking too much.
- 8f2ab37a-ed6c 10mo agoWhere have you been able to find ultralight springs available to consumers? I was looking into this last week and the 10-20g ones were only available straight from the factory in South Korea with shipping costing $200... I was happy to get them and swap them out, but that shipping pricetag was too much of a highway robbery. Would appreciate any advice here :) And, intrigued about the idea of not using key switches at all. Are there any aftermarket alternatives available online for "keycaps" that are better at softening the impact on the finger, something softer and bouncier perhaps? Seems like something people would have experimented with.
- loeg 10mo agoHey, if they can commercialize this into a real therapy, that would be amazing.
- jmward01 10mo agoI wonder if this would apply to backs/back injuries. This is super exciting, if it pans out. I can't wait for the follow up research. A pill that 'just works' is an amazing thing. Loosing mobility later in life leads to a lot of problems so directly attacking the cause of (a lot) of mobility loss is really great to see.
- leechy 10mo agoTurns out the pain in my knee was a latent infection with staph aureus, forming small nubs under the skin. Debrided the skin, removing the nubs, applied 3% doyiciclin creme and pain is gone. This for a knee with 2 operations before and teo doctors saying I need a replacement. Doctors are mostly unhelpful idiots imho.
- aeonik 10mo agoYea, same here, following the studies had helped me fix a 18 year old shoulder tendon issue. I owe that research group a lot.
- giardini 10mo agoWhat happened to you? Might anything you have learned help me? Recommended reading? I too have a shoulder tendon issue: 14 months ago a loud one-time "pop" occurred while doing a simple external rotation shoulder exercise with very light weight. I immediately lost most strength lhs and the shoulder felt very loose. More than a year later + 1 steroid shot my shoulder is much better but still loose.
- aeonik 10mo agoIt's complicated, rotator cuff tear combined with a bunch of rib, shoulder and neck injuries. I never properly healed them, just rest, career in tennis ended after trying to rest and heal 3 times over 8 years. YouTube and Physical Therapy combined with the UC David protocol has brought back more strength and mobility than I've ever had. My main issue I had before was I kept pushing my injury too hard without proper remodeling. The UC Davis protocol requires a specific isometric, loaded stretch while dosing Vitamin C and Type 2 Collagen an hour before isometrics. It took about 6 months before I felt it getting significantly better, and I'm not fully healed yet, but I can actually throw balls to my kids without feeling my injury now.
- giardini 10mo agoThank you! I searched for "UC Davis protocol for shoulder" and found Dr. Keith Baars at UC Davis and his research on tendons: [Tim Ferriss podcast re Baars' work at https://tim.blog/2025/02/27/dr-keith-baar-transcript/ https://tim.blog/2025/02/27/dr-keith-baar-transcript/ and "dastratman" has produced an excellent summary of Baars' and Ferriss' discussions: https://hackmd.io/@dastratman/rygQhSmhke https://hackmd.io/@dastratman/rygQhSmhke ] I searched your old HN posts and found that you've explained this before to HN denizens! Thank you, thank you so much! FWIW I've never been able to throw w/o shoulder pain and, now that you mention it, I may make it my goal to build up to that!
- mcswell 10mo agoAnecdote for any runners reading this: I'm a 75 year old runner. (Some young runners might say I run at a jogger's pace, I just tell them to keep off my lawn.) A couple decades ago, I stopped running on concrete or asphalt, and took up trail running, i.e. running on (mostly) dirt. It feels way easier than running on asphalt, much less on concrete. If you're skeptical that running on concrete or asphalt feels harder, give it a try. YMMV, but I'd bet you notice a difference. And yes, I do fall sometimes, tripping over roots or rocks. But I recover quickly.
- mancerayder 10mo agoI'd worry about sprained ankles on a false step or a slippery leaf-rock trap. Is there a technical approach to running in these conditions?
- ImPleadThe5th 10mo agoI've heard it's actually beneficial for your ankles long term to get some tilt/pan on them. It reduces your chances of injury by strengthening the twitch muscles in your ankle and legs. Important to note the point is "trail running" not "alpine running", gravel and dirt vs, steep inclines and big rocks. Anecdotally, just adjust your pace/length until you're comfortable. I've always done mixed asphalt/dirt-trail and there is a notable difference in my knee fatigue when there is a bigger ratio of one or the other, would always prefer a nice gravel or dirt over the road.
- deleted 10mo ago[deleted]
- davkan 10mo agoYou just get used to trail running over time. If you’re nimble and light on your feet a slip almost never turns into a fall. With practice you dodge the bad steps without much thought or you step knowing it’s iffy, slide and keep running. You don’t commit hard down on your heel. The form i use basically the “natural” running style. Land with your body over your foot, land on your foot flat or on the ball. This is good for trail running because it’s much easier to not commit to a step when you’re not planting hard with your heel. I’ve never sprained an ankle trail running, not that it can’t happen. I’ve gone like 90 degrees on my ankle before but I can usually unweight and collapse on that leg and catch myself on the other leg and keep running. I run in sandals and I backpack in trail runners. Trail running strengthens your ankles what with all the uneven ground that has to be compensated for.
- tmtvl 10mo agoI've been having good results with recovering my knee's cartilage with Flexofytol, which is based on Boswellia Serrata and curcuma.
- bikenaga 10mo agoSomething similar was done in a sheep model: "A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model" - https://www.pnas.org/doi/10.1073/pnas.2405454121 https://www.pnas.org/doi/10.1073/pnas.2405454121 "Abstract: Regeneration of hyaline cartilage in human-sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity and sufficiently robust physical properties to withstand joint stresses offer a promising strategy. We report here on a hybrid biomaterial that combines a bioactive peptide amphiphile supramolecular polymer that specifically binds the chondrogenic cytokine transforming growth factor β-1 (TGFβ-1) and crosslinked hyaluronic acid microgels that drive formation of filament bundles, a hierarchical motif common in natural musculoskeletal tissues. The scaffold is an injectable slurry that generates a porous rubbery material when exposed to calcium ions once placed in cartilage defects. The hybrid material was found to support in vitro chondrogenic differentiation of encapsulated stem cells in response to sustained delivery of TGFβ-1. Using a sheep model, we implanted the scaffold in shallow osteochondral defects and found it can remain localized in mechanically active joints. Evaluation of resected joints showed significantly improved repair of hyaline cartilage in osteochondral defects injected with the scaffold relative to defects injected with the growth factor alone, including implantation in the load-bearing femoral condyle. These results demonstrate the potential of the hybrid biomimetic scaffold as a niche to favor cartilage repair in mechanically active joints using a clinically relevant large-animal model."
- WalterBright 10mo agoI run regularly. Some years back I switched from a heel strike stride to a ball-of-foot strike. It greatly reduced the shock load on my knees and hips. It's the same gait you'd naturally do if you took off your shoe and ran barefoot.
- kenjackson 10mo agoCurious, does anyone know if this might also apply to tendons? I've had patella tendonitis for years (jumpers knee) and have tried everything (isometrics, shockwave, PRP injections, etc...).
- wooger 9mo agoAnd you've been to a physio? As far as I recall, the treatment I was prescribed for the same thing was mostly eccentric single leg squats, ideally on a 30 degree angled board. And rest...
- kenjackson 9mo agoYep. Do those on a slant board. And knee extensions. And a few others. Plus drink collagen before it. I’m still working my way through it so it might work, but I’d love for something like this to work.
- SilentM68 10mo agoMy body is a mess! Where do I sign up :)
- appguy 10mo agoATG exercises have helped me with my knee pain. Their exercises help to strengthen the cartilage and ligaments around the knee.
- callipygiton 10mo agoBetter than mesenchymal stem cells?
- silexia 9mo agoI am 41 years old and have had hip osteoarthritis since I was 36. I am not supposed to do a hip replacement at such a young age, they prefer older people with weaker muscles to do less damage to an artificial joint. A cure like this would be a godsend for me.