8 ms·
Ageing accelerates around age 50 ― some organs faster than others
- msie 1y agoUgh, I can feel it!
- neom 1y agohttps://archive.is/45ZuW https://archive.is/45ZuW Study: https://www.cell.com/cell/abstract/S0092-8674(25)00749-4 https://www.cell.com/cell/abstract/S0092-8674(25)00749-4
- braingravy 1y agoWorth noting the restricted range of the model sample: 76 people ages 14-68.
- beej71 1y agoThis certainly matches my personal anecdata. :(
- wiz21c 1y agoit's worse than that, I can feel it :-) I'll be old when I'll be old. Not before ! :-)
- randenauthor657 1y ago[dead]
- exe34 1y agoMine started late-thirties. Stomach doesn't handle spices as it used to. Any bravery at dinner time means poor sleep and tiredness for a day or two. Bumps/strained things take days to stop hurting.
- piombisallow 1y agoIt's very likely that aging is driven by some kind of scheduled gene program. It makes perfect sense to phase out individuals from a group-level selection point of view.
- kkoncevicius 1y agoThis would be an optimistic scenario and introduce a possibility for the "scheduled gene program" to be controlled or turned off. The current thinking in the field seems to favour the idea that aging is a complex combination of programmed changes, stochastic damage, as well as various adaptations to help cope with the damage.
- piombisallow 1y agoMenopause is also an obvious planned partial shutdown (vs males who can reproduce when they're 80) and we're no closer to "curing" it, turning it off.
- rowanG077 1y agoI don't think there is much interest in stopping menopause. So you are right we can't cure it. But I don't think that's a good indication.
- NoOn3 1y agoMaybe. But why in this case do we not see bugs and failures in this program, i.e. no one lived 5 times more than the average or did not live forever at all, for example? I'm not making a statement, just a guess.
- hyperman1 1y agoYou could say this woman is immortal. Or at least her cancer is. https://en.m.wikipedia.org/wiki/Henrietta_Lacks https://en.m.wikipedia.org/wiki/Henrietta_Lacks
- jgalt212 1y agoAll the recent pop sci I've read is the accelerated aging periods in one's life during our 40s and 60s. https://med.stanford.edu/news/all-news/2024/08/massive-biomolecular-shifts-occur-in-our-40s-and-60s--stanford-m.html https://med.stanford.edu/news/all-news/2024/08/massive-biomo...
- wonderwonder 1y agoI felt incredibly old from ~36 - 42. Then I started seriously working out, took control of my diet (it had very much always controlled me) and started aggressively pursuing a "better living through chemistry" approach to life. I feel 25 years younger now. My BP and cholesterol are under control and I roll out of bed actually feeling rested (probably due to not snoring anymore).
- SoftTalker 1y agoI started weight training at about age 54. I had never done any form of regular exercise in my life. Attempts here and there, but nothing ever stuck for very long. I am stronger now than I ever have been.
- embwbam 1y agoI’ve been athletic most of my life. At 42 I feel much older than at 32. Chronic injuries add up! Be careful out there everybody
- zemvpferreira 1y agoHave you happened upon Keith Barr’s work on tendon repair? Up to a few years ago tendon injuries were thought to be mostly unfixable (you could strengthen what was left of an injured tendon at best) but Barr’s work is proving otherwise. And using a very low risk isometric exercise protocol. It won’t make you feel 32 again but it might help you get rid of a lot of lingering aches and pains.
- wonderwonder 1y agoI combined vitamin C with a daily dose of collagen and it did wonders for my tendons when combined with stretching exercises. My Achilles went from constant pain and at least a couple hours every morning of hobble walking to no pain and just feeling like normal. The doctor recommended surgery and even then made no promises. I still can't run for any real distance but the quality of life difference of just being able to walk without pain and do heavy calf lifts in the gym is immense. Note: I also aggressively supplemented with BPC-157, GHK-cu and TB-500 to get to where I am.
- ck2 1y agoWait until you get long-covid, it really stomps on the aging accelerator
- 31carmichael 1y agois that a real thing?
- slantaclaus 1y ago*aging
- exegete 1y ago“Ageing” is in the original title and is also correct.
- koakuma-chan 1y agoIt's only correct if you're in the UK or Canada
- mellosouls 1y agoI've only opened these comments in the hope somebody here will debunk these findings or at least point out they are dubious... :(
- 77pt77 1y agoWould it make you feel better if the cutoff was 40?
- pinkmuffinere 1y agoI'm 30, so maybe still too young to have a meaningful perspective, but I take comfort in the fact that I will always get to choose what I _try_ to do. I can't control my body's state, but I can insist on doing exciting / eventful stuff until my body gives in. My friend's grandma (80+ yo) just flew from Bay Area to Paris on her own, to catch up with old friends. I'm pretty sure her doctors would advise her not to do that trip, but she is doing what she wants. I admire her for making the choice to assert her free will, despite the increased risk; I aspire to be like that.
- OneMorePerson 1y agoIt is interesting how the perspective of society can set an expectation of not doing certain things. Of course its personality and body/health dependent but I've seen 95 year olds still doing daily light farm work and totally independent until the day they passed away, or seen 75+ year olds out there on some pretty challenging hiking trails. There's no reason why an average older person can't still do a ton of things.
- evo_9 1y agoAgree - I’m 58 and still do the same workout I did in my 30s and 40s including 3 sets of 15 to 20 pull-ups depending on the day. I also still skate (hockey) 2 -3 times a week with a bunch of retired pros (echl, nhl, etc) and typically put up a bunch of points every skate (possibly slightly more assists now but I attribute that more toward enjoying that more these days and not needing to be so flashy)
- 1y ago
- hn_throwaway_99 1y agoThere was another recent study that made the front page of HN (would have to search to find it) that found two "peaks" of aging, at 44 and 60. As someone in my late 40s, I certainly identified with that. I was in fairly good shape and feel like, despite some grays and some crows feet, my body was relatively the same from my early 20s to my early 40s. 44 really did hit me like a ton of bricks though - working out got considerably harder, and my face started to show more permanent signs of aging, like loss of facial fat and neck banding. Can't say I was thrilled to later discover I was "right on schedule".
- anal_reactor 1y agoI'm 30. I feel 70. No clue why. I take vitamin supplements, I exercise, I try to sleep, I had basic blood test. Nothing.
- dnissley 1y agoHow's your diet? Do you get plenty of vegetables? Cruciferous especially. Do you avoid fried foods? Alcohol? Caffeine? Sugar? Consuming enough high quality protein? How's your sleep? Do you avoid eating within a couple hours of bedtime? Are you waking up to pee in the night?
- anal_reactor 1y agoI used to eat a salad every day until recently when I decided I can't be bothered to visit work canteen anymore. They gave shit food but I'd always take an extra big salad of raw vegetables. Recently my diet got worse. I used to love cooking, but now I can't be bothered, so it's instant ramen, milk with buckwheat, or potatoes + egg + bacon + fried vegetables. Not sure what "high-quality protein" is. I had a period when I'd drink a litre of vodka every weekend, but now it's like "one beer to chill after work". Weed is my vice though, I'm stoned every weekend. I try to cut though because the amounts I used to consume now make me tired, so I'm aiming for smaller doses. I try to eliminate caffeine, but I keep learning about new sources of it. It's literally today that I learned just how much caffeine cola has. Sugar is my vice definitely. I cycle every day, so I burn it. When I don't cycle I hit the gym. Sleep... it happens often that I schedule time to sleep, I put away my phone, but then I just don't fall asleep, I just lie there awkwardly in bed. Or I wake up and then can't go back to sleep. I feel like the quality of my sleep isn't there really, which is why I decided to cut caffeine in the first place. But then I sometimes have a streak where I can sleep and function well. One thing is that I tend to get sleepy in the afternoon. If I go to bed and manage to get one full cycle of sleep, I won't feel completely miserable. I don't have big meals before bedtime but often I keep snacking on something. Whether I wake up to pee depends on how much liquid I drink before. I'd say 50/50.
- drgo 1y agoI think this study adds to growing evidence that aging doesn’t progress linearly. There’s less evidence supporting a specific inflection point for aging. If aging is like any other biological process, it’s likely to vary a lot between individuals depending on genetic, lifestyle and environmental factors and within an individual between different tissues. Until we develop accurate measures of tissue aging, there’s much we can do other than live as well as we can and as hard as possible.
- tangent-man 1y agoShould be against Hacker News policy to post pay-walled sites. What is this BS?