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Surgeons transplant pig kidney into a patient
- 0xedd 3y ago[flagged]
- deleted 3y ago[deleted]
- uaserussia 3y ago[flagged]
- fithisux 3y agoIf it works, why die? You have a chance.
- uaserussia 3y agoWhy would I care at that point? I'm not living with a pig's heart. That's disgusting. Imagine someone being so afraid of dying they were willing to have a pig's heart transplanted. There's nothing someone like that wouldn't do.
- Supermancho 3y agoKidney*
- John23832 3y agoTell that to diabetics. Prior to the invention of synthetic insulin, we used pig and cow pancreas secretions. You're making an unneeded distinction. If YOU would like to die, so be it.
- uaserussia 3y ago[dead]
- viciousvoxel 3y agoImagine someone being so afraid of a little piece of their meat being replaced that they would rather die. My point is, you're allowed your opinion, but if you're simply deriding others for not sharing yours, you're not really enriching the conversation.
- uaserussia 3y ago[dead]
- quasarj 3y agoBahahaha wtf you are so out of touch, I can't even! But by all means, turn down the kidney, pass it on to me! I'll happily piss on your grave with my shiny new swine-urine
- bumby 3y agoYou realize that 1-3kg of "you" is already bacteria, right?
- stainablesteel 3y agoquite impressive, there must have been an insane amount of work that went into this the forecasting market should capitalize on if someone dies who is it or who dies first? this guy or the neuralink patient
- huytersd 3y agoIt doesn’t mention the most important thing. Does he have to take immunosuppressants? If so is it for the rest of his life.
- eadmund 3y agoI don’t feel like that’s the most important thing. If we can farm kidneys for folks with kidney failure, rather than rely on a combination of the kindness of live donors and harvesting organs from corpses, it will be a huge step forward, even if recipients still need immunosuppressants (as they do with human organs). I do wonder if the immunosuppressants for cross-species organs have to be stronger/nastier than for intra-species organs though.
- huytersd 3y agoI didn’t realize you had to take lifelong immunosuppressants with human organs as well. That makes this indistinguishable, provided it keeps working.
- ejolto 3y agoI'm curious, when did you think patients had to take immunosuppressants?
- Fomite 3y agoThere's also a number of autoimmune diseases out there...
- mschuetz 3y agoImmunosuppressants are very commonly used for various diseases that are caused by overreactions or undesired reactions of your immune system. Glucocorticoids, for example, are very widespread for all sorts of stuff (rashes, asthma, allergies, inflammations, ...). Monoclonal antibodies are also getting popular as a way to treat allergic reactions by means such as "killing" your IgE antibodies (They're basically antibodies that, in this instance, are used against your own body's antibodies).
- ThinkBeat 3y ago[flagged]
- office_drone 3y agohttps://archive.is/gzSFf https://archive.is/gzSFf
- msie 3y agoVery promising!!!
- stakhanov 3y ago[flagged]
- simion314 3y ago[flagged]
- andyjohnson0 3y ago> This is confusing, because one possible reading of this is that the procedure works only on Black people. Thats not a reasonable interpretation. They're just saying that the recipient is a member of a group with higher rates of kidney disease, and therefore the transpant techniques may particularly (but not solely) benefit that group. The rest of your comment is unnecessary supposition.
- martinky24 3y agoDude is just looking for a culture war.
- stakhanov 3y ago[flagged]
- pdabbadabba 3y agoWhat it is very clearly saying is this: > The patient is a Black man, and the procedure may have special significance for Black patients [because they] suffer high rates of end-stage kidney disease. I grant you that the grammar of the sentence does leave a smidgen of ambiguity. But I don't see any other plausible reading if you bring even a little bit of context to the interpretive exercise--which is just as much a part of reading as understanding the syntax. The author is justified in expecting that good faith readers will understand the final clause as explaining the clause that goes immediately before it. It's also a huge and unreasonable leap to go from "this sentence has a slight ambiguity" to "the sentence can be reasonably interpreted to mean that the procedure only works on black people." It can't.
- 3y ago
- slibhb 3y ago[flagged]
- martinky24 3y agoInequality exists in the health system, especially for exclusive treatments like supply-limited organ transplants. Pretending it doesn't is ignorant and naive.
- deleted 3y ago[deleted]
- burrish 3y agoI mean it's a fact that Black people have a higher chance of suffering from a kidney disease. (I wonder why too)
- deleted 3y ago[deleted]
- martinky24 3y agoIt's hard for me to imagine the bravery it takes to sign up for this -- even if you're dying already, something like this is unlikely to result in a peaceful final days on earth (between being a science experiment, the media, optional major traumatic surgery, etc...). The folks undergoing this are incredibly admirable.
- thefounder 3y agoThe alternative is certain death so not a lot to choose from
- Rinzler89 3y agoAll death is certain. And taxes.
- deleted 3y ago[deleted]
- kerkeslager 3y agoDisagree. The "choose life at any quality of life" ideology causes immense suffering. Ideally in the long run, this is a step in the direction of keeping people alive with a higher quality of life, but that's unlikely to be this first person's experience.
- acchow 3y agoDoctors (and society) should not be encouraging this mentality. But individuals surely have the freedom to think like this and make decisions accordingly.
- hsbauauvhabzb 3y agoDon’t many religions encourage the complete opposite mentality? Shouldn’t they be censored also?
- 3y ago
- Ekaros 3y agoWhat happens to other parts from these genetically modified pigs? Can some be used for other transplants? Can rest be eaten?
- huytersd 3y agoI don’t think you’d want to eat severely genetically modified pigs though. Who know what kinds of viruses can make the jump to humans in a chimera like that. Ideally those pigs would be kept in some kind of sterile biohazard location and their bodies would ideally be incinerated afterwards.
- hsbauauvhabzb 3y agoDo we also do that to the organ recipient?
- huytersd 3y agoWell the organ recipient’s body is now an incubation chamber for pig human virus crossovers. But it’s a human, so we deal with the risks. Hopefully he doesn’t deal with a lot of pigs on a daily basis.
- quasarj 3y agoI have CKD and need a transplant. I'm keeping an eye on this progress. I hope I get to eat the rest of the pig when I wake up from the surgery, myself. Mmmmm bacon!
- paul7986 3y agoAs a mild CKD patient 60 to 80 percent fluctuating function (diagnosed at 55 function raised it to average 75 for many years until a recent illness) I avoid all meats except chicken..sometimes turkey. Drink 3 liters of water a day (80 percent of a gallon). Of course Everyone's ckd journey is different
- wiz21c 3y agoI remember this; didn't last long :-( https://www.npr.org/2022/03/09/1085420836/pig-heart-transplant https://www.npr.org/2022/03/09/1085420836/pig-heart-transpla...
- reocha 3y agoDifferent cases and different organs
- userbinator 3y agoI remember that too, and can't believe it's already been a year since that happened. Now I wonder what the next organ to cross the pig-human border will be.
- John23832 3y agoIf successful, this is great. However, I would like to see how long this lasts. I can recall seeing similar stories with either a rejection at the end, or some negative outcome for the patient.
- quesera 3y agoEven if not successful, it's fascinating and a necessary step along the way to something that is successful. Good luck to the guy though!
- adamredwoods 3y agoThe hearts lasted weeks, about 2 months. The test primate for the kidney lasted 2 years, which would be impressive.
- candiddevmike 3y agoHow many times can you receive a transplant for the same organ? Does scar tissue for at the transplant site?
- mikeInAlaska 3y agoSpeaking for liver transplants, they are a many hour traumatic affair. My daughter lost and received more than her entire blood volume during hers. Initial recovery is extremely immunosuppressed and some of the drugs we had to handle with masks and gloves, and had 4x a day medication schedules. So you couldn't burn through pig livers I believe getting them swapped frequently. My daughter received her liver at age 8 months by the way and is now 19 yrs old.
- skeaker 3y agoJust curious, about how long does the initial recovery phase last? Congratulations to your daughter by the way, happy you all pulled through.
- quesera 3y agoIt's impossible for me to see this as anything but an amazing development. But the sentient-pig SF horror genre pretty much writes itself.
- whythre 3y ago… does it? It’s a kidney, not a brain. Brain transplants from a pig seem like a pretty obviously bad idea.
- quesera 3y agoSorry, overcomplicating English syntax: The ... SF horror genre, as written by sentient pigs ... pretty much writes itself.
- egorfine 3y agoBut you never know until you try.
- selcuka 3y agoYou meant until the pig tries. A brain transplant is a misnomer, it's actually a body transplant.
- BizarroLand 3y agoSome people are injecting BDNF from pig brains into themselves, and early insulin came from pigs as well. Hopefully this works or if there are issues they are minor. https://www.alzdiscovery.org/cognitive-vitality/ratings/cerebrolysin https://www.alzdiscovery.org/cognitive-vitality/ratings/cere...
- adamredwoods 3y agoQuite amazing! Doubtful we'll see any Animal Farm animals. The modified genes are for mostly endothelial modifications. >> The Yucatan miniature pig breed was chosen because its organ sizes are comparable to human organs28. In addition, pigs with OO blood type were selected to eliminate ABO blood-type incompatibilities29. >> The pigs were engineered to carry 69 genomic edits, using the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-mediated nonhomologous end joining and homology-directed repair30,31, and recombinase-mediated cassette exchange. https://www.nature.com/articles/s41586-023-06594-4 https://www.nature.com/articles/s41586-023-06594-4
- TrinaryWorksToo 3y agoIt's easy to transplant a pigney into a human. The hard part is keeping them alive afterward, especially in the long term. It seems like the event is not far enough in the past to know.
- selcuka 3y agoNot the same as a human, but transplants to other primates were moderately successful [1]: > Researchers transplanted kidneys from genetically engineered Yucatan pigs into cynomolgus monkeys such as the one above. The monkeys survived for up to two years with the xenografts. [1] https://www.scientificamerican.com/article/monkeys-with-transplanted-pig-kidneys-live-for-up-to-two-years-or-more/ https://www.scientificamerican.com/article/monkeys-with-tran...
- barbazoo 3y ago“easy”
- TrinaryWorksToo 3y agocomparatively
- y04nn 3y agoI would like to have more details on the list of genetic modifications needed to make the kidney implantable in an human without being rejected/attacked by the immune system.
- kovacs_x 3y agoI'm sure (99.9%) its patented, so you can find and read those patents. i expect there should also be a list of publications in it what it was based on. its probably heavy biology / chemistry though (i know, as I've been researching other gene modification patent stuff before)
- iancmceachern 3y agoIt's so interesting. It was done over the course of decades by the company that made Dolly the cloned sheep all those years ago. There are a handful, maybe a dozen genetic changes that were needed, but that's not the most interesting part. Endemic to the general swine population are several retrovirus'. They are communicable, so they had to create an entirely separate breeding population of these pigs, with the genetic modifications, and then raise and otherwise maintain a breeding population that is totally separate from other farms. Something as simple as a feed truck delivery could lead to a compromise. Think about a farm, but total microbiological isolation.
- kovacs_x 3y agoimo only way forward (in broad terms) is taking ones cells, fixing dna/genes, growing cells as neccesary and transplanting them back and having valid cells of your own making. everything else is just suffering and living with "incompatible" parts.
- deleted 3y ago[deleted]
- BizarroLand 3y agoThat would be the holy grail, but there are innumerable hurdles to cross first. They seem to have had success with making a bladder: https://www.bbc.com/news/business-45470799 https://www.bbc.com/news/business-45470799 But a bladder is just a tube. Cultivating and growing a multilayered higher functioning organ like a kidney or a heart is a lot harder. I do hope they can pull it off though, especially if they can reset the genetic clocks on the new organs. I imagine there are trillions of dollars on the line as well. Organs are big money and necessary for life but there's also the plastic surgery aspect. For instance, new skin. I could see 25-50 years from now being able to go to the doctors and drop off a few skin cells and then coming back 3 months later, shucking your old skin and getting the new skin put on, floating in a star wars bacta tank for a week or so while the nerve integrate and the sutures heal, and then coming out looking like a teenager again. But not just for old people but for burn victims, too. Of course, while you're at it, get your new heart / lungs / kidneys / knees / eyes / hair follicles / breast & genital upgrades / remove all of the excess fat from your body / upgrade muscles / get a new set of adult teeth installed / get any bone level deformities handled... The wealthy could go into these retreats for a few months and come out as basically a brand new human if they had the cash or credit.