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A nasal spray protects against coronavirus including immune-evasive variants
- imperio59 4y agoDr. McCullough has been recommending people use diluted povodone iodide solution for a couple years already. I've done this anytime I felt cold symptoms coming on and they usually disappear within a few hours. It's pretty much common sense, most bacteria and viruses for respiratory infections live in the upper respiratory tract and multiply there. Kill them at the source and your infection tends to resolve much faster...
- gruez 4y ago>Dr. McCullough has been recommending people use diluted povodone iodide solution for a couple years already As a nasal spray? The wikipedia article describes it as being primarily used on skin. Is it safe to spray that into your nose?
- innocentoldguy 4y agoThere are nasal spray products on the market. https://www.epothex.com/products/povidone-iodine-nasal-spray-30ml-epothex https://www.epothex.com/products/povidone-iodine-nasal-spray...
- logicalmonster 4y agoApologies for hijacking your comment, but who or what flagged imperio59's relatively benign comment? I can't respond directly to that. Kind of weird that this was shut down so quickly.
- sillysaurusx 4y agoYou can try vouching it by clicking on its timestamp and then "vouch". Both mods and the community have the power to flag comments; mod decisions can't be overridden, but community decisions can. The fact that it's [flagged][dead] instead of [flagged] implies that the community flagged it, though it being collapsed seems like a new change that might indicate moderator intervention.
- seattle_spring 4y agoI didn’t flag it, but I probably would have. The doctor (Peter McCullough) mentioned has been very vocal in spreading debunked information, including: * Telling people to use Hydroxychloroquine to treat covid * Claiming that there’s no evidence of the novel coronavirus being spread asymptotically * Claimed without evidence that the covid-19 vaccines have been linked to hundreds of thousands of deaths worldwide And spread or supported basically every other heterodox-sphere conspiracy theory, including that it was a “plandemic”, ivermectin nonsense, etc. This is HackerNews, not ZeroHedge.
- TonyTrapp 4y agoThere's already some nasal sprays around that supposedly protect against Covid-19 in a similar way. However many places online just echo the copy from the manufacturers about the efficiency. Has anyone tried those sprays and can share their experience?
- seattle_spring 4y agoWhich sprays specifically?
- jedberg 4y agoIf you're talking about the nitric oxide spray, my friend used it at a conference and got COVID anyway, so where n=1, it didn't work. But then again, almost all of us got COVID. I was masked the whole time, he used the spray, others took no preventative measures, and it didn't seem to matter much.
- devmor 4y agoYour anecdote and other similar stories I've heard seem to lend credence to one of the biggest factors for covid spread being circulated air systems. It's one of the biggest reasons I don't want to return to working in an office any time soon.
- anonymous_sorry 4y agoI don't think we need to resort to anecdotes to conclude this. I think it was some time during the first wave that scientists began to communicate that indoor and enclosed spaces were far more risky than outdoor and well ventilated places.
- devmor 4y agoOh sure, but since a good half of the US doesn't believe in science I think it's nice to point out that people's personal experience corroborates it.
- ncr100 4y agoMore: - https://www.pandemblock.com/products https://www.pandemblock.com/products - https://www.nature.com/articles/s41467-023-37290-6 https://www.nature.com/articles/s41467-023-37290-6 Q: how would this be to take, if it's ever human certified? Are there similar nasal immunity products, using similar molecular mechanisms?
- op00to 4y agoYes, see iota-carrageenan sprays.
- kepler1 4y agoI wonder if a nasal spray (or a tablet) is enough to make vaccine deniers change their minds. Sometimes you wonder, is all the ridiculousness of their protest because they're just afraid of needles and injections?
- eastbound 4y agoYou might want to listen to what they say instead of listening to what media says about them. Perhaps you have one in your family. Anyway, so no I don’t care about injections, I care that the same people who obviously lied to us 6 times, are the people who tell us “This time, we’re right, we know what we’re doing.” The show Chernobyl is excellent in demonstrating how each type of personality deals with news in a regime where everything is false, some of them not even having recognized that the communist regime’s output were systematic lies. So what happened to Facebook censoring doctors because they said the virus would behave in waves, and at that time, the theory of waves was a conspiracy, so we shouldn’t have known about it?
- waboremo 4y agoWhat are the 6 lies they told?
- blueyoda 4y ago[flagged]
- waboremo 4y agoAh I understand the problem, nuance is difficult in public. Most of these weren't unanimous arguments by doctors. Masks for example: it's true they are ineffective at preventing most things, you can't put on a mask and be free of disease from others, it's mostly to spread it from you. At the same time, some masks are more effective than others, when most people were buying up cloth masks they didn't want to discourage this by redirecting to more effective masks especially at a time where hospitals were struggling to get those needs met and they were at much higher risk. So you see how something like that, when edited through soundbites and malicious actors, suddenly becomes "they lied about masks"? Now reevaluate the rest of your beliefs about how they "lied" during that time.
- HellsMaddy 4y agoFor how long does the spray protect you? Is this something you'd use on a daily basis?
- op00to 4y agoA few hours, says the article.
- AiaAidan 4y agoIntranasal administration of just 5 or 50 micrograms of TriSb92 as early as 8 h before but also 4 h after SARS-CoV-2 challenge can protect from infection. Source: https://www.nature.com/articles/s41467-023-37290-6 https://www.nature.com/articles/s41467-023-37290-6
- peteradio 4y agoHow does this work? It sounds like its not a vaccine (your immune system is not invoked) but something that attaches to the spike protein and inhibits it from entering cells. But how could a nasal spray last a long time? Is this something that needs to be used continuously?
- op00to 4y agoYou ever have boogers hang out in your nose for a while? Like that.
- VagueMag 4y agoIt just reduces the amount of virus which can reproduce in your nasal cavities, giving your innate immune response a better chance at fighting it off before it gains a foothold. I've mostly seen it recommended as something to do after significant exposure events like being among large crowds indoors.
- thenerdhead 4y agoSeems like a cool concept for future pandemics. These types of things are always cool to see even if they are a bit late.
- photochemsyn 4y agoFull article with supplemental data: https://www.biorxiv.org/content/10.1101/2021.12.28.474326v1.full.pdf https://www.biorxiv.org/content/10.1101/2021.12.28.474326v1.... > "The intranasal dose of TriSb92 that should be administered to susceptible persons prior to events involving a risk for SARS-CoV-2 exposure remains to be established but is likely to be substantially lower than extrapolation of our current data on mice that were challenged by inoculation of the rather massive amount of 2x105 PFU of SARS-CoV-2 into their respiratory tract." Side effects might be an issue but that should show up in well-designed clinical trials. It sounds like something that people working in infectious clinical settings might want to use, maybe immunocompromised people who have to go out in public, but otherwise, for general use seems iffy in terms of efficacy.
- hammock 4y agoIf the FDA approves it or the CDC recommends it, I’ll trust it, more than what some internet commenter says
- bira 4y agoYou'd be surprised then to know what FDA once approved that later turned out to be detrimental to patients' healthy. Happened more than once.
- Arainach 4y agoThe list of "things the FDA once recommended but retracted" is many orders of magnitude shorter than the list of "things someone on the internet shilled that turned out to be incredibly toxic and probably not beneficial at all"
- deleted 4y ago[deleted]
- icehawk 4y agoI mean, that's a useless number unless I know the list of things that the FDA once approved and then did not turn out to be detrimental to patient's health. I'd be more surprised if it didn't happen more than once in 117 years.
- fnordpiglet 4y ago(In mice)
- Perenti 4y agoMy housemate was part of this study. He noticed his hayfever stopped.
- upwardbound 4y agoIt sounds like the nasal spray has a molecular structure based on the shape of a key molecule unique to Covid. Is it possible that your housemate thought they were experiencing regular hayfever but actually it was hayfever + fighting off a mild Covid infection at the same time? That's the only way I can imagine to explain what you described.
- seanmcdirmid 4y agoIt could be that any nasal spray would have had that affect, even just a weak water only one. Considering that nasal irrigation is a treatment for hay fever, I can see it having some effect even if the medicine part isn’t applicable.
- deleted 4y ago[deleted]
- sparker72678 4y agoThis study does not seem to have been performed on humans. Perhaps your housemate was part of a different study? (Or your housemate is a mouse?)
- cirrus3 4y agoIs your "housemate" a rat? > In laboratory animal studies, a molecule known as TriSb92...
- deleted 4y ago[deleted]
- Alex3917 4y agoThere are lots of nasal sprays that may potentially be protective against covid, e.g. Betadine Cold Defence, but almost all of them are banned for sale in the US. But you can buy pure saline nasal spray for a couple dollars at Target, which itself is likely protective.
- cactusplant7374 4y agoHow does this thing stop a virus as it claims?
- erickhill 4y agoSo... several years out for use in the US assuming it passes clinical trials?
- momirlan 4y agothat would pose a problem for the medical state. how can you enforce "vaccination"?
- taneq 4y agoAt you trying to imply that the government wants people vaccinated for some reason other than to stop them getting sick?
- kennywinker 4y agoSince absolutely nowhere forced vaccination, and the restrictions related to vax status have been gone for quite a while now, it really seems like you’re shadowboxing enemies that don’t exist
- VagueMag 4y agoSince the initial outbreak of SARS-CoV-2 I have kept bottles of Betadine nasal spray around. They say "clinically proven to reduce cold symptoms on the packaging," always seemed reasonable to think it might work as well against this coronavirus as all the others.
- yosito 4y agoHow often are you actually using it? I would imagine long term use of nasal betadine could have some negative side effects.
- VagueMag 4y agoAgreed. I don't take it very often, maybe once every few weeks or so, slightly more often if I start feeling symptoms.
- bwilli123 4y agoUniversity of Western Australia Study finds nasal spray could aid battle against COVID Nasodine Nasal Spray is based on povidone-iodine, the same active ingredient found in Betadine throat gargle, and has been in development for almost a decade as a treatment for the common cold. Laboratory experiments showed a 15-second exposure to the nasal spray reduced infectivity of SARS-CoV-2 by 99.97 per cent, while a 60-second exposure completely eliminated viral infectivity. A subsequent pilot study of six COVID-19 patients, who were shedding the virus from the nose, looked at whether the laboratory results translated to people. The trial showed that a single Nasodine dose (four sprays per nostril) reduced viral shedding in five of the six subjects (83 per cent) at five minutes after the dose, with an overall 79 per cent reduction in viral shedding at one hour after the dose. https://www.uwa.edu.au/news/Article/2022/February/Study-finds-nasal-spray-could-aid-battle-against-COVID https://www.uwa.edu.au/news/Article/2022/February/Study-find...
- bwilli123 4y agoPovidone-iodine (taken nasally or as a gargle) kills viruses and bacteria. All types, including Covid, with 99.9% effectiveness according to numerous studies. Has worked this way (and safely) since the 1950's. Given that it's effective, and cheap to produce it's no wonder big pharma lobbied so hard for their own expensive partial treatments.
- jupp0r 4y agoThis was tested in mice. I'll hold my breath until I see human trials.