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Scientists discover a highly potent antibody against SARS-CoV-2
- mechanical_bear 5y ago404?
- derecerca 5y ago@dang: this should be the proper URL: https://actu.epfl.ch/news/scientists-discover-a-highly-potent-antibody-again/ https://actu.epfl.ch/news/scientists-discover-a-highly-poten...
- byproxy 5y agoOops! Yep, looks like I mis-entered the URL and can't seem to edit. =/
- dang 5y agoNo, you entered it fine, but our software has recently begun rewriting URLs to the canonical URL if the page has one, and this page has //actu.epfl.ch/news/scientists-discover-a-highly-potent-antibody-again/ ...which isn't valid, but we might as well tweak the code to handle such cases. In the meantime I've restored the URL. Sorry for the error!
- mircea 5y agoThat's a valid URL, AFAICT. https://www.paulirish.com/2010/the-protocol-relative-url/ https://www.paulirish.com/2010/the-protocol-relative-url/
- pvg 5y agoAs the other comment says, it's a valid URL but to really rub it in, the canonical link RFC (6596) says it's valid and then also uses a relative URL in an example like they were just waiting for someone to be wrong about this on the internet.
- mechanical_bear 5y agoThanks
- The_rationalist 5y agoOr simply upregulate your lymphocite T by 600%..
- denton-scratch 5y agoI thought "potent" was a term referring to the strength of a particular composition of a particular drug. I thought "powerful" was the term that you could use to compare one drug to another, irrespective of dose. Have I got it back-to-front?
- viraptor 5y agoThey're pretty close. If you're a descriptivist, then they're both interchangeable in practice.
- denton-scratch 5y agoI'm not a descriptivist! I think that everyone should speak English the way I speak it! (I'm right, and everybody else is wrong) It's awful, being a prescriptivist. Everything you read howls at you "Ignoramus journalist!", and everyone you meet seems to be foreign. Every dictionary seems to have been compiled by an "algorithm", based on some irrelevant corpus; and the meanings of words I thought I knew keep shifting. I guess defending Norlins against a hurricane tidal surge must have felt a bit like this. Maybe I should just chill a bit more.
- viraptor 5y agoIt is awful, you're rarely right as a prescriptivist because descriptivists decide what "right" is :)
- colechristensen 5y agoI don’t think either word has a particularly strong definition behind it in this context. Happens a lot in science, some words have very strong very specific meanings in scientific contexts… others not much at all.
- hanselot 5y agoWhen the cine shills and bots haven't figured out what the new script is yet...
- calebm 5y ago"The newly identified antibody was isolated using lymphocytes from COVID-19 patients." So currently, the only people who have this antibody are people who have had COVID, correct?
- fastaguy88 5y agoOnce you have characterized an antibody that works, you can manufacture it.
- macksd 5y agoHow would it be different from the monoclonal antibody treatments already available?
- evilpotatoes 5y agoBetter cross variant effectiveness, longer lived in blood.
- thedrbrian 5y agoGiven that survivors have already manufactured a shed load of it can they have a vaccine pass?
- colordrops 5y agoHow do you make money off of them if you give them a pass? I haven't seen any science at all that indicates vaccines are better than natural immunity. But beware saying that outloud. Other countries acknowledge this and treat natural immunity similar to being vaccinated, but the US will not due to economic interests. I challenge anyone to show data otherwise before they reflexively down vote.
- colechristensen 5y agoI really don’t think it’s economic interests, it’s politicizing and moralizing science by people who don’t know enough.
- deleted 5y ago[deleted]
- hadlock 5y agoBased on the five or six "variants being monitored" that present actual threats, it seems like the virus adapts within 18 months, which is pretty fast for researchers to find new solutions, test them in a population safely, and then get the FDA to safely approve them. Are we going to get to a situation like the annual Flu vaccine, where it is tested and released in (what I'm guessing) less than a year? Otherwise, it seems like we'll be chasing this virus with outdated solutions forever. Moderna and Pfizer are both currently testing a vaccine that is specific to Delta, but by the time it's approved (my guess: January/February) the current wave will be long behind us.
- bawolff 5y agoI don't think that follows. I don't see why rate of adaption would stay consistent with the early stages of a new virus in later stages. I don't see how you conclude the virus adapted after 18 months due to six variants of concern existing. Especially because existing solutions are still very effective with the new variants, even if its somewhat of a decline. Even if you accept that as "adaption" its still a sample size of 1.
- amluto 5y agoThe latest papers suggest that delta has very little vaccine-evading ability. It’s more contagious in general, and the Pfizer/BioNTech vaccine is less effective after several months than would be ideal. Of course, this means that most breakthrough infections are delta.
- xapata 5y agoWhile we may have some uncertainty about SARS-CoV-2 specifically, it seems clear to me that in the long run we'll need to treat coronaviruses in general much like influenza viruses. So, yes.
- nradov 5y agoThere are already 4 other endemic coronaviruses. We seldom treat them with anything stronger than chicken soup and Tylenol. Most of us get infected when we're young and the resulting immunity protects us as we age.
- shusaku 5y agoIs there any actual precedent for the scheme they present here (basically preventively give these antibodies to people who can’t mount their own response every 6 months)? Do we already do this with other diseases?
- KZerda 5y agoWe do it with cancer already. https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/monoclonal-antibody/art-20047808 https://www.mayoclinic.org/diseases-conditions/cancer/in-dep...
- inter_netuser 5y agoThat is indeed a fairly routine treatment for people with primary immunodeficiency. One of the ways they are diagnosed is inability to develop antibodies after a vaccine challenge. Those people receive an infusion of human antibodies purified from donated blood (human immunoglobulins) every few weeks. It's been in use for several decades.
- vimy 5y agoMonoclonal antibodies are already successfully being used. This is just a press release from another company wanting in on the action. Honestly surprising why so few people know about the antibody therapy we already have, reduces death by 80 to 90 %. Also unclear why we still need vaccine mandates when we have a cure. https://floridahealthcovid19.gov/monoclonal-antibody-therapy/mab-locator/ https://floridahealthcovid19.gov/monoclonal-antibody-therapy... https://www.washingtonpost.com/health/covid-monoclonal-abbott/2021/08/19/a39a0b5e-0029-11ec-a664-4f6de3e17ff0_story.html https://www.washingtonpost.com/health/covid-monoclonal-abbot...
- JonathanFly 5y ago>Honestly surprising why so few people know about the antibody therapy we already have, reduces death by 80 to 90 %. Also unclear why we still need vaccine mandates when we have a cure. Do promptly delivered monoclonals blunt your body's natural immune response and prevent natural immunity, as your body doesn't need to make its own antibodies? If so, all the more reason to get vaccinated as soon as the engineered antibodies fade. Or before treatment, I don't see why having both wouldn't be extra effective?
- tasogare 5y ago> Also unclear why we still need vaccine mandates when we have a cure. Corruption. It always have been the alpha and omega of this whole vaccine story, minus the part where governments went on-board as a way to restrict citizens right.
- creatonez 5y ago> This is just a press release from another company wanting in on the action. Was the URL changed? This is a press release from Swiss Federal Institute of Technology Lausanne and Lausanne University Hospital, both public institutions.
- vimy 5y agoNo, I was sleep deprived and made a mistake. :p
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- deanclatworthy 5y agoI’ve heard about these MCA treatments in articles but am surprised to hear in these comments about it actually already being in use. My father is an immunocompromised transplant patient and has been isolating now since the start of the pandemic. His first two vaccines had no antibody response and we will get results on his third dose in just over a month from now. The situation has been really difficult for us as a family and he’s not had human contact this whole time (lives alone, I’m in another country). His renal consultant and local NHS consultants offer no hope or mention of MCA treatment. Has anyone more information on this in the UK?
- JonathanFly 5y agoA quick google search suggests they should be available now. The article specifically talks about the situation your father is in: https://www.pharmatimes.com/news/nhs_patients_gain_access_to_covid-19_treatment_ronapreve_1378149#:~:text=The%20UK%20has%20secured%20supply,monoclonal%20antibodies%20%E2%80%93%20casirivimab%20and%20imdevimab https://www.pharmatimes.com/news/nhs_patients_gain_access_to.... >Initially, Ronapreve will be targeted at hospitalised patients who have not mounted an antibody response against COVID-19. >This includes individuals who are immunocompromised, such as patients with certain cancer or autoimmune diseases.
- deanclatworthy 5y agoThanks for the reply Jonathan. Sadly just for those who it's probably too late for, and a reactive response rather than pro-active (i.e. to prevent being hospitalised in the first place, given the amount of damage getting to that point can cause to an immunocompromised patient's body in the long term).
- pkpioneer 5y agohttps://pkpioneer-health.blogspot.com/2021/10/if-youre-pregnant-and-havent-gotten.html https://pkpioneer-health.blogspot.com/2021/10/if-youre-pregn...