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Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painki
by fencepost 9y ago
Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out.
Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?
- elchief 9y agosome people can't handle the effect on the stomach. but if you can handle it, it's a good choice. Or marijuana
- lcfcjs2 9y ago+1 for Marijuana. Both ibpuprofen and aspirin have Ripped my stomach up (I took it every day for eye migraines for years). I still have stomach issues.
- ribosometronome 9y ago> marijuana Unless that makes you anxious.
- toomanybeersies 9y agoIn that case, use ketamine? In all seriousness though, there is research being done and evidence to suggest that ketamine can be used for pain management. Most of it seems to be about using it synergistically with opioids, to reduce the amount of opioids required.
- pennaMan 9y agosadly ketamine has severe side effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678404/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678404/
- lobf 9y agoCBD?
- emacsgifs 9y agoUnless you're not in a marijuana friendly jurisdiction
- guelo 9y agoMarijuana kills your short term memory.
- hprotagonist 9y agothe low/no-thc high-cbd strains generally don’t do this.
- dzhiurgis 9y agoIt does screw up your sleep massively (basically REM sleep is gone)
- hprotagonist 9y agoit can, yes. i still dream at a microdose level.
- deleted 9y ago[deleted]
- Grazester 9y agoI tend to use naproxen but something tells me that would kill me as well
- dwyerm 9y agoI think that all NSAIDs (like naproxen and ibuprofen) chew holes through your stomach lining, and a whole class of them were yanked from the market for causing heart attacks[1]. (But, yeah, naproxen seems to be one of the safest ones...) [1] https://en.wikipedia.org/wiki/COX-2_inhibitor https://en.wikipedia.org/wiki/COX-2_inhibitor
- crx087 9y ago> (But, yeah, naproxen seems to be one of the safest ones...) Kind of. But it starts to feel a little uneasy taking it all the time once you realize that naproxen's regulatory approval came from https://en.wikipedia.org/wiki/Industrial_Bio-Test_Laboratories https://en.wikipedia.org/wiki/Industrial_Bio-Test_Laboratori... data.
- maxerickson 9y agoThat study also raised concerns about older NSAIDs (including aspirin, acetaminophen and ibuprofen): http://circ.ahajournals.org/content/115/12/1634 http://circ.ahajournals.org/content/115/12/1634
- arkades 9y agoAll stomach effects are due to decreased prostaglandin levels. All NSAIDs function through inhibition of prostaglandin synthesis. The exception is Tylenol/acetaminophen, as it doesn’t have an anti-inflammatory effect / doesn’t seem to act primarily on COX1/2. It’s currently popular to bandy about the theory that it targets spinal COX3.
- Hello71 9y agohttps://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory...: "NSAIDs cause a dual assault on the GI tract: the acidic molecules directly irritate the gastric mucosa, and inhibition of COX-1 and COX-2 reduces the levels of protective prostaglandins" (emphasis added)
- StreamBright 9y agoWell you can still use CBD though.
- TheSpiceIsLife 9y agoIn case you were wondering: Cannabidiol (INN;[3] abbreviated as: CBD) is one of at least 113 active cannabinoids identified in cannabis.[4][5] It is a major phytocannabinoid, accounting for up to 40% of the plant's extract. https://en.wikipedia.org/wiki/Cannabidiol https://en.wikipedia.org/wiki/Cannabidiol
- ChristianGeek 9y agoIt’s worth noting that a legal version, extracted from Hemp (a form of Cannabis that has no psychoactive properties), is available via mail order anywhere in the U.S.
- rhexs 9y agoI looked into the hemp based extract a while back and the conclusion I drew was that it was up for debate whether or not it was legal. Proponents cited a bunch of laws regarding industrial hemp while the DEA seemed to have another position entirely. Was this finally settled or is it still a bit gray?
- pasquinelli 9y agoi've heard of a cbd extract from hops, but i'm not sure whether it's true.
- dropden52 9y agoSince vitamins and supplements are totally unregulated it could be that it doesn't actually contain any of the active ingredient it claims it does, thereby avoiding any legal issue.
- Bud 9y agoHemp is not "a form of" cannabis. It IS cannabis.
- TheSpiceIsLife 9y agoInfrequent, occasional use of opiates, for two or three days shouldn't be a problem. You do have to make a bit of an effort to get addicted to opiates, insofar as taking a pill a day for a couple of weeks constitutes effort.
- chrsstrm 9y agoI had seemed to think that 10 days was the threshold but it turns out to be half that - http://www.newsweek.com/cdc-opiate-addiction-572498 http://www.newsweek.com/cdc-opiate-addiction-572498
- TheSpiceIsLife 9y agoGreat reference, thanks! From the link you provided: According to the report, the transition from an initial prescription to chronic use begins very early on. Even a one-day opioid prescription carried a 6 percent risk of use at one year later and a 2.9 percent risk of use at three years later. The sharpest increases in the likelihood of long-term use came at five days after the initial prescription, with another spike seen at one month. Whoa! That's frightening.
- joezydeco 9y agoCan't use aspirin in children and teenagers because of the risk of Reye's Syndrome. https://www.mayoclinic.org/diseases-conditions/reyes-syndrome/symptoms-causes/syc-20377255 https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...
- antisthenes 9y ago1000 cases in the US, which means you're about 30x more likely to die in a car accident in any given year. Also, the syndrome isn't immediately lethal. When people worry about infinitesimally small risks, it always makes me chuckle.
- jbd28 9y ago1000 cases in the US because there are no child friendly pain medications (sweet syrup and oral syringe) but by all means risk your child’s liver to prove us all wrong
- isostatic 9y agoQuite normal in the UK to use calpol (paracetomol) and nurofen (ibuprufen) in a 5ml syringe (doses at 2.5, 5, 7.5 and 10 as the child gets older). What do you do in the US?
- sjburt 9y agoParacetamol is acetaminophen (Tylenol) and both are commonly given to children. Aspirin typically only if a doctor says it's ok.
- jamez1 9y agoThat's 1000 cases when we restrict children from taking aspirin, it could be a lot more once we let them
- tzs 9y agoNo, it was under 1000 cases per year in the US before the association with aspirin was known. Over the next 14 years it dropped to about 2 per year.
- tzahola 9y ago* and stomach ulcers
- felipelemos 9y agoI hope that dipyrone be safe.
- ansgri 9y agoMay cause agranulocytosis, according to wiki. https://en.wikipedia.org/wiki/Metamizole https://en.wikipedia.org/wiki/Metamizole
- orasis 9y agoTurmeric is my pain killer of choice.
- deleted 9y ago[deleted]
- driverdan 9y agoTurmeric is not a pain killer.
- grzm 9y agoI haven't heard that, either. I have heard that it has anti-inflammatory properties, which could indirectly reduce pain that arises from inflammation, such as arthritis. Here's one article describing it. http://content.time.com/time/health/article/0,8599,1910028,00.html http://content.time.com/time/health/article/0,8599,1910028,0... Your comment is quite brief (as is the one you're responding to, for that matter). Is there something in particular you have in mind?
- orasis 9y agoTry 1 TB/day and you'll definitely get an analgesic effect.
- Romanulus 9y agoNietzsche would advise against all forms of painkillers.
- manyxcxi 9y agoI can’t take Ibuprofen (or any typical NSAIDS including aspirin) because of a medical condition, which has sucked over the last decade because acetaminophen really doesn’t help me at all when I’m excruciatingly sore for whatever reason. In Oregon and Washington, where I’ve lived for pretty much my entire life, legal marijuana has been amazingly helpful, at least since I finally got around to trying it. The various products out that are high in CBD and low in psychoactive ingredients have been really good at even my worst muscle aches and really painful, but not super serious, injuries like sprained ankles and such. My surgeon after hip surgery even blessed the notion of using the opiates I was prescribed for as short as possible and then using high CBD edibles to cover the gap between excruciating post-op pain subsiding but still being in a lot of pain. In fact, he didn’t just bless the idea, he practically endorsed it as a “still emerging but very likely positive course of treatment” in his words. I don’t use CBD like someone might (even if maybe they shouldn’t) pop ibuprofen, but it’s great to have an option between acetomenaphin and opiates.
- adventured 9y agoIf you don't mind answering (as vaguely as makes sense), what kind of pain? Where is it focused (exclusively the hip/s?), what does it derive from? Depending on the nature of it, you might look at this: https://www.amazon.com/Genacol-Hydrolyzed-Supplement-Extra-Fast-Hydrolysate/dp/B00465XUP2/ https://www.amazon.com/Genacol-Hydrolyzed-Supplement-Extra-F... I'll suggest you do your own research on it of course. I've known a few people, myself included, that have seen extraordinary results from taking it for various pain related to anything to do with joints (very split results on working or not, seems to do amazingly for some, and nothing for others). I didn't expect it to do anything, instead it saves me from taking pain killers every day (took my pain from a persistent 5 out of 10 to a 1 or 2 on most days, such that I never need pain killers; I take two each night).
- manyxcxi 9y agoI had to have hip arthroscopy because I had an impingement, leading to quite a bit of cartilage damage/labral tearing in the joint. They even had to reshape the end of the femur to remove the impingement. It's quite a recovery period of crutches, cane, etc. and the pain from the surgery was _supposed_ to be quite immense. Honestly, my hip hurt so bad for so long that even a day post-op it was less painful than it was when I went in. I only needed the opiates for a couple of days and used CBD once or twice a day for about a week- after that the pain was just a dull soreness. Luckily, there was very little arthritis in the joint and three years post-op it's felt just fine and I've had no set backs whatsoever. Luckily I've not had to look into any type of long term pain management for anything.
- JoshMnem 9y agoAsprin seems to increase intestinal permeability. https://www.ncbi.nlm.nih.gov/pubmed/22377941 https://www.ncbi.nlm.nih.gov/pubmed/22377941 https://www.ncbi.nlm.nih.gov/pubmed/25641731 https://www.ncbi.nlm.nih.gov/pubmed/25641731
- marcosdumay 9y agoAs long as dengue fever (that has exactly the same initial symptoms as a flu) is not a possibility...
- nikolay 9y agoIn Europe, there's Aspirin-C and Upsarin, basically, pure aspirin with vitamin C, which eliminates the stomach lining issues [0]! I have no idea why this is not offered in America. Maybe, because there's no way to make money from patents and stuff! [0]: https://www.huffingtonpost.com/leo-galland-md/aspirin-and-vitamin-c-tog_b_529058.html https://www.huffingtonpost.com/leo-galland-md/aspirin-and-vi...
- arkades 9y agoI wrote a lengthy post about how ridiculous this was, until I got to the citations section, which I then dutifully hunted down. I must in all fairness upgrade this from “HuffPost-endorsed vitamin cult quackery” to “plausible, if supported by weak studies.”
- adventured 9y ago> Maybe, because there's no way to make money from patents and stuff That's definitely not the reason. The over the counter pain killer / pain management sections in CVS, Walgreens and Walmart are half filled with generic options.
- swsieber 9y agoNo, it could be the reason. The patent/money issue is related to the initial FDA approval, which is very expensive (clinical trials). If no one foots the bill for the testing, it won't spawn a FDA approved thing, right? And if it's not patentable, then it's not worth the effort to go through those hoops, because you won't be able to recoup the costs of doing the FDA approval steps because others could also bring generic versions to market right away, without a cool-down period, and at the same price. If it is patentable, then it's worth it to make the drug and get it approved. You'll have 20 years to recoup the costs before generics can appear.
- deleted 9y ago[deleted]
- 52-6F-62 9y agoGood Scotch?
- zeep 9y agoaspirin might be bad for your teeth: http://jada.ada.org/article/S0002-8177(14)61356-8/fulltext http://jada.ada.org/article/S0002-8177(14)61356-8/fulltext
- inertial 9y agoFor Dengue fever, aspirin can be fatal: "infecting organism in dengue affects the platelets which are responsible for clotting (stopping bleeding) increasing the tendency of the person to bleed. Aspirin and Ibuprofen also have similar action. Both of them together could cause the person to bleed excessively pushing the patient into what is called the ‘Dengue Shock syndrome’. And once in this stage, medical treatment is needed in an emergency basis and hospitalization becomes necessary" http://www.thehealthsite.com/diseases-conditions/dengue-fever-do-not-give-aspirin-or-ibuprofen-to-the-patient/ http://www.thehealthsite.com/diseases-conditions/dengue-feve...