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Aspirin May Prevent Cancer from Spreading, New Research Shows
- ihaveahadron 9y ago"Investigators are thus trying to develop genetic tests to determine who is most likely to benefit from long-term use of aspirin" Oh did we figure out the problem with modern medicine is that were all different subspecies of humans, or to simplify it you could say species for the slow people. Its like having prescribing the same drug to a blonde haired blue eyed person to a rat, or for you not slow people, like prescribing not to a rat but to say a bacteria. FUXKING RETARDEDPAINT HIFFING FAGGOT DOCTORS
- swah 9y agoSurely this would have been discovered by patients by accident, if it was true?
- ng12 9y agoHow? Maybe you went into remission because you took an aspirin every morning. Or maybe it's because drank a cup of coffee every day, or ate lots of greens, or spent 10 minutes in the sun every day, etc. Your body is complicated and more than likely lots of factors helped.
- sp332 9y agoThe effect in the article is just preventing metastasis, not going into remission. There's basically no way a single patient would have noticed that aspirin prevented that.
- creaghpatr 9y agoI doubt patients would consider the correlation since in their mind the effectiveness measure of aspirin specifically is pain relief rather than remission. Plus lots of 'noise' from other treatments.
- digikata 9y agoI think it would be hard to see too, but I know my grandfather for example had a long-term, small dose of asprin prescribed to him as a minor 'blood thinner'. So there perhaps exists groups of patients who could form a sample to compare against a more general population.
- deleted 9y ago[deleted]
- swsieber 9y agoI don't think so - a cancer patient is probably taking/doing so many things for treatment that they wouldn't think to attribute it to cancer. It could explain people eating healthy to get rid of cancer instead of chemo or traditional treatments - maybe they take aspirin too. I know I wouldn't give aspirin a second thought if I had cancer.
- douche 9y agoThey really do put you on some massive cocktails - notably large doses of prednisone, which is also a massively effective anti-inflammatory - so I can imagine it would be hard to pick out the causes precisely.
- carbocation 9y agoAspirin (previously erroneously typed cancer, hat tip to 'tossaway1 for the correction!) has previously been associated with reduced colorectal cancer death[1]. The cancer/aspirin link has come up a fair amount over the past few decades. 1 = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/
- tossaway1 9y agoCancer has been associated with colorectal cancer death??
- NotHereNotThere 9y agoHe obviously meant to type "aspirin" as the first word, but that was hilarious nonetheless.
- carbocation 9y agoHa! :-) Thanks to both of you for noticing this. Updated.
- deleted 9y ago[deleted]
- omginternets 9y agoThat effect size, though... :/
- erikpukinskis 9y agoBecause it's anti-inflammatory? Could be confirmation bias, but I keep getting the sense that cancer/immune failure in general is connected to our modern 24/7 eating cycle, without any down time for your body to not be inflamed and work on clearing out bad stuff. Thus life extension from intermittent fasting.
- tptacek 9y agoNot only does the article address this point, but the point is literally the focus of the whole article.
- iplaw 9y agoI abstain from food between 8PM and 12PM Monday - Friday, adjusting for training schedules and such. It really helps me keep my GI tract clear, reduces inflammation, resulted in weight loss, etc. without any effect on my cycling fitness. IF (or IMF as some people call it) is amazing.
- taneq 9y agoThat's a really fancy way to say "I skip breakfast".
- tptacek 9y agoI've fasted from ~8P to ~3P every day for coming up on 2 years and apart from making me more mindful of what I eat and drastically reducing my appetite I've experienced basically no other health benefits. IF is increasingly well studied and it is not especially amazing. (I like it a lot. Just saying.)
- ahh 9y agoHow much do you work out? I like IF a lot too, but when I'm in a heavily active phase of my life--say lifting 3x week, climbing 1x, jiujitsu 3x, and full on dance rehearsals 3x a week--I find I start to crumble unless I eat more to keep fueled.
- nonbel 9y agoThere are some interesting theories about aspirin. For example that it was Rasputin's secret healing trick to tell people to stop taking it: "Gilliard,[32] the French historian Hélène Carrère d'Encausse[33] and Diarmuid Jeffreys, a journalist, speculated Rasputin's healing practice included halting the administration of aspirin, a pain-relieving analgesic available since 1899.[34] Aspirin is an antiaggregant and has blood-thinning properties; it prevents clotting, and promotes bleeding which could have caused the hemarthrosis. The "wonder drug" would have worsened Alexei's joints' swelling and pain.[35][36]" https://en.wikipedia.org/wiki/Alexei_Nikolaevich,_Tsarevich_of_Russia https://en.wikipedia.org/wiki/Alexei_Nikolaevich,_Tsarevich_... It is also claimed to be the real cause of the "Spanish flu": "The high case-fatality rate—especially among young adults—during the 1918–1919 influenza pandemic is incompletely understood. Although late deaths showed bacterial pneumonia, early deaths exhibited extremely “wet,” sometimes hemorrhagic lungs. The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of recipients, respectively. Recently, pulmonary edema was found at autopsy in 46% of 26 salicylate-intoxicated adults. Experimentally, salicylates increase lung fluid and protein levels and impair mucociliary clearance. In 1918, the US Surgeon General, the US Navy, and the Journal of the American Medical Association recommended use of aspirin just before the October death spike. If these recommendations were followed, and if pulmonary edema occurred in 3% of persons, a significant proportion of the deaths may be attributable to aspirin." https://academic.oup.com/cid/article/49/9/1405/301441/Salicylates-and-Pandemic-Influenza-Mortality-1918 https://academic.oup.com/cid/article/49/9/1405/301441/Salicy...
- benji-york 9y ago> 8.0–31.2 g per day That is surprising amount of aspirin.
- jszymborski 9y agoyou know what they say, ten aspirin tablets a-day keeps the emergency room busy.
- aantix 9y agoAs for the internal bleeding risks, I was wondering what the actual numbers were. This is based on one low dose aspirin a day. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03077.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.... "These results translate into an absolute rate increase with aspirin above placebo (the incidence of cases of major GI bleeding attributable to low-dose aspirin) of 0.12% per year (95% CI: 0.070.19% per year).[20] Based on this value, 833 patients (95% CI: 5261429 patients) would need to be treated with low-dose aspirin instead of placebo to cause one major GI bleeding episode during a 1-year period (i.e. the NNH is 833)"
- mtgx 9y agoDoes that mean the risks are very low? What about compared to aspirin alternatives such as ibuprofen or acetaminophen (in terms of how much damage they can each cause to the body, and which is safer)?
- matt4077 9y agoAcetaminophen in particular is somewhat scary. Just 2.5x the recommended maximal daily dose of 4g can lead to complete liver failure. With alcohol, other medication, or existing damage, much less could be enough.
- nostromo 9y agoA friend of mine swears that the reason acetaminophen is added to opioids (like hydrocodone) is so that you cant abuse the opioid without being poisoned by the acetaminophen. If true, it's alarming that the way to "prevent abuse" is to poison the patient.
- snerbles 9y agoA more extreme example of this concept is denatured alcohol, which is ethanol adulterated to deter consumption. https://en.wikipedia.org/wiki/Denatured_alcohol https://en.wikipedia.org/wiki/Denatured_alcohol
- jszymborski 9y agoAnyone have a link to the paper? I'm usually the first to criticise popsci treatments of cancer developments, but this actually seems to be an interesting study/development.
- carbocation 9y agoIt seems the author is referring to a few papers, but the one most directly related seems to be http://atvb.ahajournals.org/content/37/4/664.long http://atvb.ahajournals.org/content/37/4/664.long I don't see a free, open-access form available.
- vermooten 9y ago'may'
- noam87 9y ago(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition and decreased expression of CTLA4/PD-1. It's kind of sad, but it seems that too often vital lines of research sit on university shelves for years before anything practical is done about it :/ (disclaimer: not an expert; just guy with cancer.)
- dmichulke 9y ago> Even the standard book "The Biology Of Cancer" (2014) mentions it Is this book ok for people with other backgrounds or does it require a good foundation in medicine or biology? And could a programmer (that knows how to learn) deal with it without spending months on research? Thanks and all the best wishes!
- noam87 9y agoum some parts are more high-level than others, but a lot would be gibberish. Familiarity with the contents of e.g "Molecular Biology Of The Cell" would greatly increase your experience. -- That book is big and exhaustive (and expensive), a focused intro to the same material is MIT "Introduction To Biology" on EDx! It's an amazing course! The book and MIT course also give a good enough conceptual intro to the chemistry concepts you need too. Obviously the rabbit hole goes deeep tho... people spend lifetimes scratching the surface.
- jjtheblunt 9y agoThere's documentation of firocoxib (a partially selective COX-2 inhibitor used in veterinary medicine) with efficacy against osteosarcoma, for instance.
- ajnin 9y agoNSAID: Nonsteroidal Anti-Inflammatory Drug
- jtwebman 9y agoSo goes eating a whole plant based vegan diet. https://www.forksoverknives.com/science-says-about-diet-and-cancer/ https://www.forksoverknives.com/science-says-about-diet-and-...
- agumonkey 9y agoTalking about simply accessible products, anybody has knowledge about cannabinoids (specifically cannabidiol, not THC) ? I've dug as deep as I could from someone out of a lab and found tons of evidence, but the issue is that doctors have each a different point of view on it. So far I got: - it's innocuous but help opioids for pain - it's potentially antitumoral but human studies are lacking [0] - it's been studied and discarded because useless [1] - cannabis derivatives are toxic [2] - what's cannibidiol ? oh USA use that, Europe lags behind, I'll see [0] mice model with human cancer lines showed regression, look for pierre yves desprez or sean mcallister on pubmed, youtube has a talk where some patients reported IRM visible regression on stage IV cancer [1] renowned oncologist opinion, yet so many research on cannabidiol still going ? odd [2] so far I've yet to find more than one paper listing toxicity (except one talking about accidental overdose on that one hypersensitive person that used her daughter's provider) I'll take any info just in case.
- mohawk 9y agoSorry haven't got much time at the moment, here's the paper that got me interested Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html Put that into Google Scholar (the paper title or just "guzman thc"), then click on the Cited by xxx below in the search results to find newer papers. GW Pharma is a company doing clinical trials, and i think Canadian licenced producers of cannabis are doing trials as well (though i don't know how many are about cancer/anti-tumoral activity). Here's a long list of research papers on cannabinoids: http://www.cannabis-med.org/studies/study.php http://www.cannabis-med.org/studies/study.php
- agumonkey 9y agoOh I know that, I mailed Cristina Sanchez about her research. I looked for the GW trial (brain metastasis IIRC) in UK but so far couldn't find any results. thanks for the other link, I never looked at that website before. ps: and to add to the theories, Desprez cbd research hints at ID-1 transcription regulation; ID-1 appearing to be a embryogenic-time gene, turning cells into highly mobile and differentiating regime => aggressive tumor. If CBD does interfere with ID-1 expression, it's not implausible that tumors grow much more slowly and locally, which is probably always good. pps: one more thing, cbd and cannabinoids have a huge image problem; people just dismiss it as hippie shit.
- joshgel 9y agoProbably more interesting is that the USPSTF recently added a recomendation for aspirin use to prevent colorectal cancer in certain populations[1]. There is increasing levels of evidence about this, though it is by no means certain.[2] [1] https://www.uspreventiveservicestaskforce.org/Page/Document/draft-recommendation-statement/aspirin-to-prevent-cardiovascular-disease-and-cancer https://www.uspreventiveservicestaskforce.org/Page/Document/... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354696/