xyhopguy

11 ms·

61.
by xyhopguy 8y ago
IMO AI/ML scientists are drastically underestimating the complexity of biology. Once scientists in biology and healthcare get on board like they are in linguistics and computer vision I'd expect things to pick up.
62.
by xyhopguy 8y ago
Eh I disagree. It's been known for a while that you need something other than just DNA to get the heterogeneity of cellular phenotypes. Remember that your Iris and toenails have the same DNA, yet wildly different gene expression profil
63.
by xyhopguy 8y ago
Maybe ten years ago I watched Bob Kennedy Jr or 3 or something talk about having battery swap stations instead of charging stations. Seemed interesting but I don't know much about batteries!
64.
by xyhopguy 8y ago
I think that's how you derive UCB, but optimizing cumulative regret rather than finding the probability distribution directly. Pls correct me if I'm wrong
65.
by xyhopguy 9y ago
Feels a lot more like NYC is an anomaly where no one cares about rules directly impacting them. The Pacific Northwest in general seems to have a more communal culture (moreso Oregon than Western Washington). But NYC.... Dear lord.
66.
by xyhopguy 9y ago
Within 20 miles of somewhere like Portland for that matter. My in-laws live in the Portland burbs and everything between their house and the next town is farmland.
67.
by xyhopguy 9y ago
> (particularly the "go back" one). Holy shit, once I built a web app for some biologists that wanted a "designer wizard." First I implemented a really shitty buggy wizard. Then I refactored it all into a state machin
68.
by xyhopguy 9y ago
I've also done this math -- price per sqft is wayy better in Seattle and you don't necessarily need a car. In any case, a metro card isnt cheap. The cost of groceries/alcohol is also much much higher in nyc and at a lower qua
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by xyhopguy 9y ago
Interestingly enough, I grew up in a small town outside Corvallis. Moving to a city as (relatively) big as Corvallis was pretty weird.
70.
by xyhopguy 9y ago
Bioinformatics is perpetually ten years behind. The de facto standard for sequencing data is effectively a stripped down bzipped plain text file. It's madness.
71.
by xyhopguy 9y ago
just freestyle, nice and relaxed. swimming distance isnt the best measure though, some people are more/less efficient than others.
72.
by xyhopguy 9y ago
used to do this during swim practice. unbelievably relaxing and amazing how far you can swim without a breath with a slow buildup. we used to go up to 4 lengths aka 100m
73.
by xyhopguy 9y ago
MCTS has always been popular and probably the best online/out-of-the-box MDP technique. But fundamentally its different than RL methods. In MCTS you assume you have a perfect simulation of the MDP which is rarely true outside of games.
74.
by xyhopguy 9y ago
I don't really know any history about cancer research, but as long as I've been in genomics people have talked about it. Difficulty is actually finding CNVs. These days it's not so hard. It's also important to remember t
75.
by xyhopguy 9y ago
Personally I see crispr more as a tool for functional genomics. It took like two decades to knockout all pairs of genes in yeast. With crispr I've seen people do it in a single experiment.
76.
by xyhopguy 9y ago
can't say too much but I work on the stats side of liquid biopsy. Been in genomics (on the cs side) for the last 6 years. the encouring part to me is 1) we can predict the effect of a treatment given the tumors clonal composition, 2) w
77.
by xyhopguy 9y ago
My (weak) understanding is that the functional impact of a mutation is more important than the type of variations. Otherwise we would see recurrent point mutations rather than hotspots right? FWIW though, people have already been able to pr
78.
by xyhopguy 9y ago
Those already exist! TCGA for starters..
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by xyhopguy 9y ago
To be fair though, we are really close with cancer. Like really really close. cfDNA is revolutionary for our measurements. Crispr is revolutionary for understanding. So close.
80.
by xyhopguy 9y ago
It's worse than that. It turns imaging data (illumina basecaller) into sequences, aligns them, turns them back into images (nucleotides go into the same channel for some reason), THEN uses 100x more compute to get a questionable 1% gai
81.
by xyhopguy 9y ago
The biggest complaint about DeepVariant is that it isn't even a CV problem. I mean you start with a bunch of images, but those get processed and turned into basecalls, which get aligned to the genome, and then turned into an image agai
82.
by xyhopguy 9y ago
even nature is hyping the verily paper now? It's like I'm taking crazy pills. Variant calling was already very very good and grounded in statistics. Why ON EARTH do we need to convert it to AN IMAGE and give it 1000x more compute?
83.
by xyhopguy 9y ago
The suburbs also have urban growth boundaries (parents live next to one) and it's easy to build over single family homes. The people and the city don't seem very interested however. The whole state is really antigrowth and it has
84.
by xyhopguy 9y ago
there is also a mountain range in the way.
85.
by xyhopguy 9y ago
Dang sorry man that wasn't what I meant. The Ugb encourages density as you said, which is quite good if you want a comprehensive transit system.
86.
by xyhopguy 9y ago
maybe if they weren't so vulnerable to climate change. My money is on Portland. Good climate projects, tons of natural resources, strong urban growth boundry restricting sprawl. If the state ever figures it's shit out Portland wou
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GATK implements deep learning for variant calling(software.broadinstitute.org)
1 points by xyhopguy 9y ago|0 comments
88.
by xyhopguy 9y ago
They will never be able to address the issues in New York. The whole place is polluted to hell -- the beaches are gross and dirty. I mean for fucks sake you have to ASK to not get a plastic bag (usually two). What year is it, 2002? The plac
89.
by xyhopguy 9y ago
i wouldn't call new york an example of a "high quality of living." Subways that barely work? Terrifyingly chaotic traffic? A "me-first" attitude that is visible everywhere from the people complaining about citi-bike