vibrio

19 ms·

211.
by vibrio 5y ago
I agree with your wine-drinking physicians on clinical trial participation, and your question on how to improve broader participation. I also believe that there are fundamental difference in cancers that arrive in a young person versus can
212.
by vibrio 5y ago
While mRNA vaccines were great in the COVID situation, they have been in development over the last decade and I'm not sure an HIV vaccine will be as simple as putting HIV envelope protein into this technology. I'm not aware of att
213.
by vibrio 5y ago
I think "grift" is a bit cynical. I agree the 'biobucks' concept largely exits, but it also good deal-making. A huge upfront is 100% risk on the buyer. Paying out incrementally for accomplishments is common and good busi
214.
by vibrio 5y ago
I believe DARPA is a national treasure, and has driven a ton of otherwise neglected innovation, but let's not overstate their contribution to Moderna. For exsmple, AstraZeneca did a deal with Moderna including a $240MM upfront to anoth
215.
by vibrio 5y ago
Grow some various peas. Carefully and in a controlled manner cross pollinate them. Follow traits like wrinkled peas vs smooth peas, or yellow peas vs green peas. If keep good records and do a bit of math, you'll learn a lot about gene
216.
by vibrio 5y ago
Came here to say exactly this. I'll add that my media library is very music heavy, and Plex is doing a pretty good job on its music player Plexamp.
217.
by vibrio 5y ago
That incubator held bacterial plates for cloning. The ants would walk across the plates and sometimes leave a trail of bacterial colonies showing the path they took. Cleaning the area and turning the incubator up to 45-50 Celsius for a day
218.
by vibrio 5y ago
I accidentally pulsed an ant in micro-centrifuge once, achieving a few thousand x g momentarily. The ant was still walking after, albeit less well. I was surprised the ant made it. Note: I am not a sadist nor an ant-torturer. The ant evide
219.
by vibrio 5y ago
Part of the concern around this work is that the PNAS publication route suggests that teh work didn't survive traditional peer-review. Should all peer review be abolished as data suppression, and we just go the bioRxiv route for all in
220.
by vibrio 5y ago
Pardon the snark- it was not intended to be aggressive. I'm a microbiologist and have spent much of my life thinking about virus biology and pathogenesis. My perspective is skewed from general public but over the last year, the frequen
221.
by vibrio 5y ago
Yes, and birds fly frequently, but elephants don't seem too. All viruses are not the same, they are extremely diverse.
222.
by vibrio 5y ago
"it's possible" means something very different to scientists than it does general public or popular media. Scientists rarely say impossible. The effect is of like "theory of evolution". This makes it hard for
223.
by vibrio 6y ago
They did a great job with the mRNA vaccines, but they have been prolific in research for nearly decade. In my opinion a intersting question is whether infectious disease vaccines now matter to the "wealthy world", as infectious di
224.
by vibrio 6y ago
"next target"? has been a target since inception. At Moderna or BioNtech Cancer and Gene Therapy were priorities during the last decade or so, with limited evidence of success as far as I can tell. Infectious disease is scientif
225.
by vibrio 6y ago
per google translate, it may have more information but not more data, nor independent confirmation of the experts' opinions.
226.
by vibrio 6y ago
Based on all the information provided in this article, this article is premature to publish. The headline is accurate, as 'experts say', but lack of any independent support of data supporting the claim, makes this dubious (at best
227.
by vibrio 6y ago
$1B seems like a quite a bargain when you look at Tesla $TSLA or Moderna $MRNA valuations with any sort of fundamental analysis. (flame proof suit on)
228.
by vibrio 6y ago
Just realized I got the original morph direction wrong. Please pardon.
229.
by vibrio 6y ago
Yes, many things are theoretically possible. In relative terms Coronavirus isnt that mutagenic. Every year for many years millions of people get seasonal coronaviruses there hasn’t been a “morph” (whatever that means). The SARS and SARS&#x2
230.
by vibrio 6y ago
No. Mo more than a tiger will morph into a house cat.
231.
by vibrio 6y ago
I think this is an economic barrier more than a scientific one (not that the science is trivial). MERS is too sporadic. SARS burnt out to quickly to substantially test anything clinically, and if you look at the scientifc literature, inter
232.
by vibrio 6y ago
Growing wild-type coronavirus is easier than making the current vaccine approaches? How/Why? As someone familiar with virology and cGMPs, I don’t see how that is the case.
233.
by vibrio 6y ago
I agree so much. Frequency at which the popular media is reporting headlines from unreviewed preprints is appalling. There should be much more journalistic discipline, but that cow has probably left the barn with the internet.
234.
by vibrio 6y ago
One would have to explain how the virus appeared in both china and Spain. Did a bat carrying it make it all that way or did the virus evolve twice independently? Both seem unlikely.
235.
by vibrio 6y ago
I agree with you that "dangerous" isn't binary. To be clear, the medical literature I was referencing are focused on medical grade HCQ. I apologize that I was glib in my "like candy" comment. I'm reacting stron
236.
by vibrio 6y ago
I'd not start dropping HCQ like candy. Beyond the retracted COVID study, it is established that there are risks associated with HCQ usage. use can lead to cardiomyopathy, prolong QT interval and trigger arrhythmia. source: drop chloro
237.
by vibrio 7y ago
I don't really know data science but in assay validation, sensitivity basically measures false negative rate, and specificity measures false positive rate. Accuracy and precision are measures of assay consistency or tightness. (statist
238.
by vibrio 7y ago
Agreed, this is made clear in the process of NIH, DoD funding. Initially I thought prosecutors and media wasre overreacting, but the scale of both the foreign funding sources and NIH DoD funding is not something that anyone could overlook u
239.
by vibrio 7y ago
Totally agreed. I'm naive to much around Ag/Husbandry. If that's what farmers do, that is a concern. From a microbiology point of view, the concept that "washing out" the drug before slaughter improves anything is f
240.
by vibrio 7y ago
It does. The animals will be colonized by bacteria that have "learned" to deal with all those antibiotics you gave. That resistance is easily transmitted.

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