vibrio

9 ms·

91.
by vibrio 3y ago
I totally agree. Although I'm not sure similar vouchers for antibiotics would be sufficient for the same success, as there are also logistical, financial and scientific advantages that have enabled rare disease drug development. Many r
92.
by vibrio 3y ago
This is a pedantic note, but in general Pharma does not care about antibiotics drug development - It’s an economic desert. If it was a cancer or serious rare disease drug, they’d be grinding up buckets of ants yesterday.
93.
by vibrio 3y ago
Point taken. I guess avoiding his martyrdom is the idea. It all seems as though the emperor has no clothes, since there is such little effort to mask what is going on and why — and what the possible outcomes for him are.
94.
by vibrio 3y ago
What use is Navalny being alive to Putin? I’m only casually familiar with the situation, but my ignorance analysis is that Putin’s underlying message is “don’t F with me”. Navalny alive and in prison or dead that message seems to ring clea
95.
by vibrio 3y ago
Yes, illegal, but so is parking in a no stopping zone. Not making excuses for him, but I have a strong reaction to the phrase “sentenced to life” seems like the dead end of a life. Because a video got leaked. Rehab isn’t an option? I&#x27
96.
by vibrio 3y ago
lol. Not intend to be snarky. I’m middle-of-the-road on Terry Gross, but the idea using Trent Reznor’s (or Gene Simmons’ being another example) temperament as a yardstick on interpersonal protocol made my morning.
97.
by vibrio 3y ago
Very clearly. Thanks for sharing.
98.
by vibrio 3y ago
Shkreli wasn’t convicted on raising drug prices. He was running multiple organizations and was using left-pocket right-pocket accounting to fund one organization with the investor funds from the other. That iwas not legit and illegal.
99.
by vibrio 3y ago
I’d ask what is driving the high cost induced by government? There are Large rigorous studies required to support efficacy and safety, and rigorous manufacturing requirements to ensure consistent drug supply for example. For sure, Pharma
100.
by vibrio 3y ago
All clinical studies are not equal so some nuance on the objective of the studies is probably important. My impression is that grant funded clinical studies tend to be earlier in development and more exploratory if interventional, or observ
101.
by vibrio 3y ago
Yes, came to say this. There are mechanisms and some economic incentives for third parties to challenge issued patents leading to invalidation. Whether there is enough economic incentive is a case by case.
102.
by vibrio 3y ago
I’ll accept only people fight wars, but i suspect wild and domestic animals commonly die in wars.
103.
by vibrio 3y ago
Low price genotyping makes me think of the maxim: “ If you are not paying for the product, then you are the product .”
104.
by vibrio 3y ago
…but have they got around the need for thermal exhaust ports?
105.
by vibrio 3y ago
Except with the Goths. They did some winning, but it seems like they didn't do much writing.
106.
by vibrio 3y ago
There is a saying with economists/financial forecasters: no model is correct, but some are useful. It's not a problem driven by journalism. There is very little (interesting or useful) fact in history, it is mostly opinion. Journa
107.
by vibrio 3y ago
If i recall, it is important to note that the main analysis in the NORDICC trial was on patients invited to receive screening. As an intent to treat study, not all received screening. There was a subgroup analysis on those that actually r
108.
by vibrio 3y ago
More interesting that debt to equity ratio, is what is done with the capital that is raised by either mechanism. Is it possible for investment into operations, marketing or strategic expansion or reduction to improve shareholder returns? Do
109.
by vibrio 3y ago
I suspect with a disinterested Congress and an apolitical Supreme Court, wringing hands over interpretation of the intended meaning of words might be predictive of legal outcomes.
110.
by vibrio 3y ago
Perhaps an example of a Streisand Effect?
111.
by vibrio 3y ago
Yes, boost shareholder return, but on what timescale?
112.
by vibrio 3y ago
The studies are now in humans, and any such gruesomeness that occurs there will be scrutinized. With the complex coverage Neurolink gets and the polarity of opinions on Musk, it will be interesting to see how patient enrollment goes.
113.
by vibrio 3y ago
The drugs may have never been developed without the CFF. They arguably took more financial risk than vertex. Vertex was trying to be a hepatitis c company at the time and cf was an off focus program that happened to come with an acquisition
114.
by vibrio 3y ago
“Man-made”: What exactly does that mean? Creation of a virus de novo? A natural isolate passaged a couple of times? Somewhere in between?
115.
by vibrio 3y ago
What discrete realistic experiment would “definitively rule out” life or water on the entire planet? How many samples would need to be microscopically analyzed to prove the negative?
116.
by vibrio 3y ago
I’m with you on this analysis, I’m good going see a local band at a club with 150 others. It’s a different objective and experience, but stadium shows seem so sterile.
117.
by vibrio 3y ago
It's important to remember that science isn't a bunch of data or experts, it is a way of thinking. That said, many don't trust the scientific system anymore. It seems like a double edged sword. We (collectively) are finding a
118.
by vibrio 3y ago
There is a device the US FDA approved for brain tumors (Optune by Novocure)that uses alternating electrical fields. It surprised the field when it got approved as its mechanism wasn't conventional or well understood. There were also so
119.
by vibrio 3y ago
It is more than just a few mutations. A good number of the common earlyish driver mutations are in the systems that detect and repair damage to DNA, which then accelerates mutation accumulation. (At some cost to stability of that lineage, b
120.
by vibrio 3y ago
Cancers actually drive blood vessel growth into the tumors to feed themselves. I’m sure they leverage that as part of dissemination. Different primary tumors (eg Prostate, breast, lung) have preferred sets of metastasis sites that are not a

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