timy2shoes

9 ms·

61.
by timy2shoes 4y ago
Or you have the classic case where the model trains on the wrong things (e.g. the classic husky/wolf and snow case). One example I heard was in heart attack risk prediction from x-rays, the model was focusing on the present of stents
62.
by timy2shoes 4y ago
It's not about revealing information, it's about how you model the problem. Say you're using logistic regression. If you upsample the minority class ( never downsample the majority class because that's statistically i
63.
by timy2shoes 4y ago
I can tell you from extensive experience that domain knowledge is more critical to understanding such issues than this algorithm. Fundamentally, such causes can not be identified if they don't exist in the data and the algorithm doesn&
64.
by timy2shoes 4y ago
> Suppose we throw 1,000 baseballs, shoot one rocket (45 degree angle), record the distance each one flew, and present the 1,001 data points to someone for analysis. But I would argue that's not really a case of an outlier, that&#x2
65.
by timy2shoes 4y ago
Not in my experience. The reason is because of funding. NIH grants are focused on biological discoveries and not so much around infrastructure. So you can get funding to build a tool, but not so much to maintain it. The downstream effect is
66.
by timy2shoes 4y ago
> Two, all the functional annotation is based off transcription profiles. They essentially looked for clusters of genes with correlated expression, and assigned function based on genes with previous annotations This is an important point
67.
by timy2shoes 4y ago
> this does not sound to me like we know the "function" of these genes, only that they're nessary for each phenotype But they're not even measuring the phenotype. They're using the transciptional signature as a
68.
by timy2shoes 5y ago
The bidding up is exactly why Zillow lost money. Algorithmic house buying suffers from the winners curse. When Zillow thinks they are getting a good deal, there are usually extenuating circumstances that are apparent to local buyers which
69.
by timy2shoes 5y ago
Starting material is a huge problem. You need at least 50ng of DNA for an Illumina sequencing run, usually more if you want to sequence ultra deep, which you will need for whole genome sequencing. For PCR you need at least 0.1ng (usually
70.
by timy2shoes 5y ago
I suspect it's because kvogt is an active member of HN: https://news.ycombinator.com/threads?id=kvogt . His (long-form) insight into this will be valuable to hear.
71.
by timy2shoes 5y ago
You don't get it in the USA.
72.
by timy2shoes 5y ago
I prefer to go to the original source, specifically The Transformers (1984-87).
73.
by timy2shoes 5y ago
The game: https://en.wikipedia.org/wiki/The_Game_(mind_game)
74.
by timy2shoes 5y ago
If he wanted to work on computer vision instead of a vegan restaurant (or something similar, I forget exactly).
75.
by timy2shoes 5y ago
The evidence definitely points the other way, see [0]. The vaccines dramatically reduce the rate of severe infection and hospitalization. The vaccines do not prevent infection, they prime your immune system to fight the infection. That i
76.
by timy2shoes 5y ago
> Any ownership required the Judge to recluse himself. Where does this requirement come from? Citation please.
77.
by timy2shoes 5y ago
Even the murder stats can be juked, like McNulty's arc in season 5 or the bodies in the vacants.
78.
by timy2shoes 5y ago
Fantastic point. Another thing about academic ml models is that they're commonly evaluated on in-sample data. For example, medical AI devices are commonly evaluated on data coming from the same source/hospital that the training
79.
by timy2shoes 5y ago
I'm not excluding the lab hypothesis, I'm just pointing our that the natural hypothesis is also valid. Honestly, I don't think we're ever gonna figure out definitively which one it was (I don't think there's a
80.
by timy2shoes 5y ago
Yes, the jumping of viruses from animals to humans due to keeping them in close proximity is so unlikely that it's happened hundreds of times before (e.g. SARS, MERS, Spanish flu, bubonic plague).
81.
by timy2shoes 5y ago
> But after the 11:46 p.m. alert came in, a ShotSpotter analyst manually overrode the algorithms and “reclassified” the sound as a gunshot. Then, months later and after “post-processing,” another ShotSpotter analyst changed the alert’s c
82.
by timy2shoes 5y ago
> My naive understanding is that "smaller p-value" == "more likely result is true". I think you're making the classic Prosecutor's fallacy: https://en.wikipedia.org/wiki/Prosecutor%27s_f
83.
by timy2shoes 5y ago
My personal opinion: I respect the opinion of a medicinal chemist working in the field of drug discovery more than I do a journalist. The insider who works in the field understands the issues and problems of getting drugs to market more t
84.
by timy2shoes 5y ago
> if the rainbow colormap is so awful, why is it still so common? Because it's the default for a lot of matplotlib visualizations. Per Goethe: "Misunderstandings and lethargy perhaps produce more wrong in the world than deceit
85.
by timy2shoes 5y ago
Exactly! This reminds of the recent case of the AMA increasing the suggested age of regular mammograms. More testing means earlier detection of breast cancer. But a false positive means an invasive biopsy. These are the two sides that n
86.
by timy2shoes 5y ago
> let's remember that the AlphaFold team at Google solved the protein folding problem with a relatively small team in a relatively small number of years after extremely large, well funded companies whose primary business was drug de
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by timy2shoes 5y ago
I think regulatory capture applies here ( https://en.wikipedia.org/wiki/Regulatory_capture )
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by timy2shoes 5y ago
> Larry Page greenlit Google Health (a terrible idea) I'm curious why you think Google Health was a terrible idea. I'm not disagreeing, just wondering your opinions on the matter from a more inside point of view. Thank you.
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by timy2shoes 5y ago
The other way around is definitely easier. RNA-seq analysis is a mostly solved problem with DESeq2 (or edgeR/limma). The tutorials are very detailed. The most difficult part is experimental design, which you probably know already. D
90.
by timy2shoes 5y ago
Although it's not a review article, but maybe Bork's The Antitrust Paradox, which the Amazon Antitrust Paradox works hard to refute.

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