thenerdhead

7 ms·

31.
Saying 'pandemic is over,' NIH institute starts cutting Covid-19 research(science.org)
32 points by thenerdhead 2y ago|23 comments
32.
by thenerdhead 2y ago
agreed on changing guidelines, disagree its unlikely to happen. the study is done and just needs to be formally published. then recommendations can "officially" change although the science has been clear about this for quite some
33.
by thenerdhead 2y ago
I am criticizing two things. 1. Science magazine's association with his recurring "editorially independent blog". I've been a subscriber for many years and have never enjoyed it personally. 2. His opinion on this topic i
34.
by thenerdhead 2y ago
Ensitrelvir is looking to apply for global approval. It may be a much more affordable option.
35.
by thenerdhead 2y ago
there are a number of computational/modeling studies suggesting paxlovid needs to be given for at least 7+ days to slow the viral load and prevent rebound. Pfizer did a preliminary study(the FDA asked them) and quietly published their
36.
by thenerdhead 2y ago
here's my page with countless findings on the topic (you be the judge and feel free to search for other studies too): https://x.com/search?lang=en&q=(paxlovid%20OR%20Nirmatrelvir... my general thoughts on this arti
37.
by thenerdhead 2y ago
I believe Science would benefit from a different approach to reporting, as Derek’s analysis over the past four years has been consistently lacking. A responsible science reporter should present the full body of evidence rather than drawing
38.
by thenerdhead 2y ago
I’d keep eyes on the immune system. We are already rethinking migraines and inflammation based on findings from COVID-19. https://www.nature.com/articles/d41586-025-00456-x Did this happen after a known infection of so
39.
by thenerdhead 2y ago
For acute yes, who knows for post-acute. Many viruses are linked to cancers, MS, Parkinson’s, Alzheimer’s, T1D and so on. Research is finding that some of these viruses may actually be low grade infections or left over viral proteins causin
40.
by thenerdhead 2y ago
https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
41.
by thenerdhead 2y ago
Or a virus known to persist in our tissues for years. Here’s yet another study suggesting persistent symptoms in kids. https://jamanetwork.com/journals/jamanetworkopen/fullarticle... More than willing to provide a
42.
by thenerdhead 2y ago
There’s strong biological evidence that SARS-CoV-2 can persist in tissues, supported by multiple studies. Before dismissing long COVID, it’s worth understanding what viruses are capable of.
43.
by thenerdhead 2y ago
That’s a fair point. Science reporting often skips the discussion section, which adds important context. A strong report would compare this with other studies to show the bigger picture, especially given concerns about undercounting. This r
44.
by thenerdhead 2y ago
absolutely, in fact many of the top ME/CFS researchers have converged their research and are teaming up with the Long COVID researchers to tackle this once and for all. we now have novel technology being used like PET scanning, T cell
45.
by thenerdhead 2y ago
It's published here. https://jamanetwork.com/journals/jamapediatrics/fullarticle/... Another publication this week showed 4% of children developed Long COVID based on EHR data. https://academi
46.
by thenerdhead 2y ago
These headlines are accurate to the study and their noted limitations, not necessarily the actual prevalence which is already known to be much higher than this. i.e. https://publications.aap.org/pediatrics/article/
47.
by thenerdhead 2y ago
Long COVID in kids is real and widespread. It’s not "rare". Far more than 200k are affected. This latest survey aligns with previous data, but it’s likely an undercount(noted by the authors as a limitation) due to reliance on pare
48.
by thenerdhead 2y ago
This reporting feels a bit superficial, especially given the exciting direction Alzheimer’s research is taking. It might sound unconventional, but what if taxi drivers, through constant exposure to small amounts of pathogens from travelers
49.
SARS-CoV-2 S Protein Blocks Type I Interferon Response(journals.asm.org)
3 points by thenerdhead 2y ago|0 comments
50.
by thenerdhead 2y ago
More antibodies against spike protein, T cells have an idea of what to respond to, and less IL-6 cytokines meaning less inflammation.
51.
by thenerdhead 2y ago
so sorry to hear you're going through long covid. i've had it for almost four years. there is a lot of hope and upcoming RCTs: https://fnih.org/our-programs/accelerating-covid-19-therapeu... here are proposed
52.
Spike protein at skull-meninges axis may drive Covid-19 neurological effects(cell.com)
13 points by thenerdhead 2y ago|6 comments
53.
by thenerdhead 2y ago
Previous COVID infection enhances immunity, creating what we call hybrid immunity. This happens because current vaccines mainly target the spike protein, while natural infection exposes the immune system to other parts of the virus. New vac
54.
by thenerdhead 2y ago
This isn’t even considering the latest being found about Covid either for long term illness/disability, virus on tumors making certain cancers grow faster, and sudden stroke/cardiac events. We are heavily undercounting until we ca
55.
by thenerdhead 2y ago
This is actually a good thing because dmca in other areas like package registries are usually behind email and you never have an idea of repeat infringers. This community oriented approach really provides enough transparency so the communit
56.
by thenerdhead 2y ago
It's more nuanced than that. genetic predisposition (immune/HLA genes working or not), infections (potential for antigen persistence), diet, environmental factors, stress, etc all also contribute heavily.
57.
by thenerdhead 2y ago
https://www.nature.com/articles/s41392-024-01911-3 https://www.nature.com/articles/s41531-024-00716-z https://www.nature.com/articles/d41586-024-00470-5 https://ww
58.
by thenerdhead 2y ago
Over the last four years we have made tremendous progress in identifying pathogenic antigens as the main culprit in these diseases. Some may be caused by undetected low grade chronic infections and some may be lingering antigens causing con
59.
by thenerdhead 2y ago
Seems odd to compare a machine like a 12 lead EKG to a smartwatch with a single lead EKG support. Of course variability will differ, that’s why they invest to much into improving the technology and ml algorithms to make up for the differenc
60.
by thenerdhead 2y ago
We are slowly learning that our immune system is the key to longevity. Many articles these last few years on ways to renew it, ways to treat dysfunction, and the common bad guys we really need to remove from our bodies as they are directly

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