4 ms·

Spike protein at skull-meninges axis may drive Covid-19 neurological effects

13 points by thenerdhead 2y ago

posix_compliant 2y ago
Anecdotally, this strongly mirrors my personal experience with long covid symptoms. I’m relatively young (32) but have noticed I don’t recover well in result to neurological injuries: loud noises which didn’t damage my hearing but left me with tinnitus, and a very mild concussion which has now taken the greater part of a year to stop feeling dizzy from.
- thenerdhead 2y ago
  so sorry to hear you're going through long covid. i've had it for almost four years. there is a lot of hope and upcoming RCTs: https://fnih.org/our-programs/accelerating-covid-19-therapeutic-interventions-vaccines-activ/recover-tlc-will-advance-long-covid-research/ https://fnih.org/our-programs/accelerating-covid-19-therapeu... here are proposed mechanisms by some of the leading researchers in this field: https://www.sciencedirect.com/science/article/pii/S0092867424008869 https://www.sciencedirect.com/science/article/pii/S009286742...
abracadaniel 2y ago
So, the more spike protein, the worse the symptoms, but also vaccination with Pfizer/BioNTech reduced the number of spike proteins stuck in the marrow. I wonder why mRNA making more spike proteins improves the situation
- birdiesanders 2y ago
  The Moderna spike and the Pfizer spike are both “inflated” by edits to the gene that cause some different arrangements of the protein structure that causes the spike to be more rigid and closer to the shape it has when embedded on the virus surface. I imagine that there is some threshold where something too thin or too small begins to be hard to clean up, and the vaccine-induced spikes are above that line, while the natural spikes detached from the virus are under. I’m a computer person so probably not correct, but I’m not blindly guessing, either.
  - abracadaniel 2y ago
    It’s things like this that constantly remind me that biology is far more complex in practice, and even while having a deeper understanding than most, I’m relying on some very grossly oversimplified abstractions.
- thenerdhead 2y ago
  More antibodies against spike protein, T cells have an idea of what to respond to, and less IL-6 cytokines meaning less inflammation.

13 points by thenerdhead 2y ago

Anecdotally, this strongly mirrors my personal experience with long covid symptoms. I’m relatively young (32) but have noticed I don’t recover well in result to neurological injuries: loud noises which didn’t damage my hearing but left me with tinnitus, and a very mild concussion which has now taken the greater part of a year to stop feeling dizzy from.

thenerdhead 2y ago
so sorry to hear you're going through long covid. i've had it for almost four years. there is a lot of hope and upcoming RCTs: https://fnih.org/our-programs/accelerating-covid-19-therapeutic-interventions-vaccines-activ/recover-tlc-will-advance-long-covid-research/ https://fnih.org/our-programs/accelerating-covid-19-therapeu... here are proposed mechanisms by some of the leading researchers in this field: https://www.sciencedirect.com/science/article/pii/S0092867424008869 https://www.sciencedirect.com/science/article/pii/S009286742...

abracadaniel 2y ago

So, the more spike protein, the worse the symptoms, but also vaccination with Pfizer/BioNTech reduced the number of spike proteins stuck in the marrow. I wonder why mRNA making more spike proteins improves the situation

birdiesanders 2y ago
The Moderna spike and the Pfizer spike are both “inflated” by edits to the gene that cause some different arrangements of the protein structure that causes the spike to be more rigid and closer to the shape it has when embedded on the virus surface. I imagine that there is some threshold where something too thin or too small begins to be hard to clean up, and the vaccine-induced spikes are above that line, while the natural spikes detached from the virus are under. I’m a computer person so probably not correct, but I’m not blindly guessing, either.
- abracadaniel 2y ago
  It’s things like this that constantly remind me that biology is far more complex in practice, and even while having a deeper understanding than most, I’m relying on some very grossly oversimplified abstractions.
thenerdhead 2y ago
More antibodies against spike protein, T cells have an idea of what to respond to, and less IL-6 cytokines meaning less inflammation.