skosuri

14 ms·

91.
by skosuri 9y ago
To be clear, a 60%-70% overhead rate implies that the university is taking 37-42% of the money (for each dollar spent, another 0.60-0.70 goes to university). In addition, other expenses like tuition and equipment have no overhead taken out.
92.
by skosuri 9y ago
Identical twins look pretty similar. Siblings only share half their genome with one another.
93.
by skosuri 9y ago
I worked down the hall from the Reich lab as a postdoc and there was a weekly data club where students & postdocs would present. One of David's people was out or something, so David gave a 30 minute slideless talk about the work in
94.
by skosuri 9y ago
I loved my time as a postdoc. It was a time to be surrounded by awesome people, many of whom are still my close friends. I spent most of my time mostly thinking about my science and what I wanted to do with it. Finally, there were very few
95.
by skosuri 9y ago
Free to Read Albeit Horrible Interface Version: http://rdcu.be/t9oS
96.
Encoding of a digital movie into the genomes of a population of living bacteria(nature.com)
91 points by skosuri 9y ago|38 comments
97.
by skosuri 9y ago
When George and Robi Mitra were working on polony sequencing [1], it seemed like a ridiculous idea that would never work or scale. I'm glad NIH and DOE weren't as shortsighted as me at the time. The efforts here and by others in t
98.
by skosuri 9y ago
Sure. Clearly anyone that actually knows what's going on is biased, and you have the clearly unbiased perspective. Pretty sure arguing here is not going to change minds. Here's a better question: Can you actually find someone who
99.
by skosuri 9y ago
I worked in George's lab as a postdoc and have helped start a couple of companies with him. This is a ridiculous and slanderous characterization of the Church lab. I'd recommend talking with folks in the lab before spreading stori
100.
by skosuri 9y ago
Really? You know NSF/DARPA/IARPA aslo fund private companies like Boeing and Lockheed. Are you saying you shouldn't have to pay for flights either because you pay taxes?
101.
by skosuri 9y ago
1. I don't know where you are getting this but this is wrong. First of all tuition doesn't pay anywhere close to even breaking even at this point much less investment. Second MIT is a private university so I don't know where
102.
by skosuri 9y ago
Just to clarify, because there is a lot of misinformation about overhead considering the Trump administration wants to cut it. 55% overhead means for every $1, another 0.55 gets routed to MIT (so about a 1/3 goes to overhead). Also, t
103.
by skosuri 9y ago
It seems to exist. Not clear there is a lot of evidence it's relevant. If you sequence a tissue that has cancer or some other disease that causes increased cell division, you will see more somatic variation. Not sure why this is partic
104.
by skosuri 9y ago
Every single microprocessor in every computer is unique in its own way (small errors in production). It doesn't mean we can't compute with them, nor that the variation is useful or relevant.
105.
by skosuri 10y ago
They don't have that at all. This was a Herculean effort over 5 years with very few actual changes to the natural genome. I don't mean to make it seem not impressive (it is ambitious and impressive); it's that we are so far a
106.
by skosuri 10y ago
Actually, it's 7 papers co-published in Science simultaneously. The others are: Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond: http://science.sciencemag.org/content/355&
107.
by skosuri 10y ago
Sure, there aren't many practical uses right now given the cost besides some niche ideas, but... 1. High cost and lack of experience are not reasons to not work on the technology. For example, quantum holography or other experimental s
108.
DeepStack: Expert-level artificial intelligence in heads-up no-limit poker(science.sciencemag.org)
1 points by skosuri 10y ago|0 comments
109.
DNA could store all of the world's data in one room(sciencemag.org)
3 points by skosuri 10y ago|2 comments
110.
by skosuri 10y ago
I wonder who the two people are.
111.
by skosuri 10y ago
Well that shouldn't necessarily be the standard. There are lots of people I know that can't do a miniprep or run a gel. It doesn't mean that those things don't work or aren't replicable.
112.
by skosuri 10y ago
I don't think making experiments more stringent is the answer here (btw, I've spent a lot of time trying to build simulations of biological systems). Usually, we aren't doing the right experiment in the first place; this is h
113.
by skosuri 10y ago
Also, you should read the Peter Walter piece that I think is the best discussion of the topic: https://www.ascb.org/newsletter/2016-marchapril-newsletter/o...
114.
by skosuri 10y ago
Yes! This is the point that most people miss. No scientist treats published studies as gospel. Our focus shouldn't be on exact replication, and should be on how generalizable such results are. If the results don't hold in slightly
115.
by skosuri 10y ago
Yes, I think you are right. I thought I remember it being heterochromat, but looking online all references seem to be to tetrachromat. In terms of evidence, I think prevalence is there, but there were some papers where they actually tested
116.
by skosuri 10y ago
I'll take a hack: 1. Imagine the retina as a field of neurons that are receptive to light. Imagine different types of neurons are sensitive to different types of light (RGB). Each person has two copies (or alleles) of the R, G, and B
117.
by skosuri 10y ago
Pt1. Again, not sure this is useful, and has been tried many times with no useful end. The major issue is that simple summaries assume papers to be true. Just aggregating papers and making summaries is basically like search and reading abst
118.
by skosuri 10y ago
Hmm, I hope they got a good price. This doesn't really seem like a pain point for researchers (at least not for me). We are all pretty adept at using existing tools to find the papers we need to find. The bigger issue is time to proper
119.
by skosuri 10y ago
There is also a good blog post by Keith Robison on why DNA synthesis businesses are hard: http://omicsomics.blogspot.com/2017/01/gen9-vanishes.html
120.
How a biotech startup rose, and then fell(bostonglobe.com)
1 points by skosuri 10y ago|1 comments

More ›