3 ms·

Actually, it's 7 papers co-published in Science simultaneously. The others are: Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI

by skosuri 10y ago

Actually, it's 7 papers co-published in Science simultaneously. The others are: Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond: http://science.sciencemag.org/content/355/6329/eaaf4831 http://science.sciencemag.org/content/355/6329/eaaf4831 “Perfect” designer chromosome V and behavior of a ring derivative: http://science.sciencemag.org/content/355/6329/eaaf4704 http://science.sciencemag.org/content/355/6329/eaaf4704 Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome: http://science.sciencemag.org/content/355/6329/eaaf4791 http://science.sciencemag.org/content/355/6329/eaaf4791 Bug mapping and fitness testing of chemically synthesized chromosome X: http://science.sciencemag.org/content/355/6329/eaaf4706 http://science.sciencemag.org/content/355/6329/eaaf4706 Engineering the ribosomal DNA in a megabase synthetic chromosome: http://science.sciencemag.org/content/355/6329/eaaf3981 http://science.sciencemag.org/content/355/6329/eaaf3981 3D organization of synthetic and scrambled chromosomes: http://science.sciencemag.org/content/355/6329/eaaf4597 http://science.sciencemag.org/content/355/6329/eaaf4597 Along with an introduction: http://science.sciencemag.org/content/355/6329/1038 http://science.sciencemag.org/content/355/6329/1038 and perspective: http://science.sciencemag.org/content/355/6329/1024 http://science.sciencemag.org/content/355/6329/1024

sytelus 10y ago
Are there any good resources to start in this field for non-biology majors? It seems they have now full end-to-end simulation so one can program yeast and even test it out at some extent with nothing but just a computer.
- skosuri 10y ago
  They don't have that at all. This was a Herculean effort over 5 years with very few actual changes to the natural genome. I don't mean to make it seem not impressive (it is ambitious and impressive); it's that we are so far away from an end to end simulation of anything even orders of magnitude simpler than yeast.
- 88e282102ae2e5b 10y ago
  Honestly, an introductory biology textbook is your best bet. But other response is correct: we can't even simulate a single protein well, much less an entire organism.

by skosuri 10y ago

sytelus 10y ago

Are there any good resources to start in this field for non-biology majors? It seems they have now full end-to-end simulation so one can program yeast and even test it out at some extent with nothing but just a computer.

skosuri 10y ago
They don't have that at all. This was a Herculean effort over 5 years with very few actual changes to the natural genome. I don't mean to make it seem not impressive (it is ambitious and impressive); it's that we are so far away from an end to end simulation of anything even orders of magnitude simpler than yeast.
88e282102ae2e5b 10y ago
Honestly, an introductory biology textbook is your best bet. But other response is correct: we can't even simulate a single protein well, much less an entire organism.