4 ms·
It seems to exist. Not clear there is a lot of evidence it's relevant. If you sequence a tissue that has cancer or some other disease that causes increased cell
by skosuri 9y ago
It seems to exist. Not clear there is a lot of evidence it's relevant. If you sequence a tissue that has cancer or some other disease that causes increased cell division, you will see more somatic variation. Not sure why this is particularly surprising or interesting. It's been known for a while now. If somatic variation was important for brain development or function (like it is in the adaptive immune system), that indeed would be super surprising, but that's not what I'm seeing here.
- mirimir 9y agoA key aspect of CNS development is massive overproduction of neurons, and then selection for useful ones. The idea that somatic variation plays a role there is not novel. https://scholar.google.com/scholar?q=development+somatic+variation+neuron https://scholar.google.com/scholar?q=development+somatic+var...