skosuri

11 ms·

61.
by skosuri 8y ago
Honestly nothing really. It’s more that there are papers that I am often the best person to review them (because of particular expertise). I often just don’t pay attention to where it’s coming from.
62.
by skosuri 8y ago
Email discussion started yesterday; amongst 20 or so faculty half a dozen agreed to not review. We'll probably discuss at the next faculty meeting or the holiday party that's about to start.
63.
by skosuri 8y ago
Well I'm on the UCLA faculty and it's definitely being discussed pretty widely amongst my department.
64.
by skosuri 8y ago
Hello :-). My method???
65.
by skosuri 8y ago
Yeah, know his work, and I don't think he'd agree with you: http://www.genetics.org/content/210/2/477
66.
by skosuri 8y ago
Yeah, sorry; I was mostly going off my own past knowledge when less was known; There's a nice summary here as well: https://en.wikipedia.org/wiki/CCR5#Potential_costs
67.
by skosuri 8y ago
The AP article does state that Michael Deem (Rice) was there for the consent.
68.
by skosuri 8y ago
Ahh I see, you are just making stuff up.
69.
by skosuri 8y ago
What you are saying is just not supported by evidence. For example, polygenic analysis of the latest meta-analysis from >250K individuals seems to say that the top several hundred variants explain in aggregrate only 5.2% of the variation
70.
by skosuri 8y ago
"Vastly increased health and intelligence"... again, you keep making assertions without any reference.
71.
by skosuri 8y ago
https://en.wikipedia.org/wiki/CCR5#Potential_costs
72.
by skosuri 8y ago
"Changes in traits, such as IQ, by 5+ standard deviations"... Where in the world are you getting this from? This is unlikely to be true for a long time. Intelligence, as far as genetics controls it, is a complex trait... with few
73.
by skosuri 8y ago
There are many people that are CCR5 null (largely in Africa due to positive selection for HIV resistance), so it's unlikely to have much effect, but still... edit: I'll also amend the statement, as the gene is implicated in respon
74.
by skosuri 8y ago
The edited gene is for CCR5, which currently doesn’t have known function, but is the entry point for HIV. So editing for prophylaxis. This was probably done because if there aren’t a ton of loss of function beneficial traits, and probably w
75.
by skosuri 8y ago
It’s hard to keep electronics going in the ocean but there is a company called Saildrone that is doing sort of what you are saying. https://www.saildrone.com
76.
by skosuri 8y ago
"Adjusted for maternal age, parity, and maternal history of psychiatric disorders"
77.
by skosuri 8y ago
All HHMI investigators went to high school as well. The reverse is not true. Getting funding in college through an HHMI fellowship is a terrible predictor of being an HHMI investigator. They are completely independent in their selection and
78.
by skosuri 8y ago
My lab was pretty well funded right from the start. A combination of early new investigator grants and generous startup packages made us worry little about money at the start. Mid career is thought to be the major crunch.
79.
by skosuri 8y ago
This is not true. There is a difference between all the other HHMI fellowships, professorships, etc and the HHMI investigator position. The latter usually requires ~5 years of being a professor before you can even apply.
80.
by skosuri 8y ago
Re: 1: It wasn’t wrong. There are Mendelian traits and complex traits. We shouldn’t forget we’ve basically tracked down most Mendelian diseases since the human genome was published. Still some to go but we will hopefully have all soon. This
81.
by skosuri 8y ago
Sort, cut and uniq are also amazingly useful.
82.
by skosuri 8y ago
Here’s a comment from me 10 months earlier. It was clear it was super sketchy for a while. https://news.ycombinator.com/item?id=9072470
83.
by skosuri 9y ago
I guess I sleep fine at night and I am faculty. It's only a pyramid scheme if you think everyone wants to become faculty.
84.
by skosuri 9y ago
Order #: 1304 It's for a stealth newco that we just started. Looking forward to playing!
85.
by skosuri 9y ago
OK. Will put in an order soon. Sri
86.
by skosuri 9y ago
Congrats! I want a OT-2! When does it ship? Also, when's the 96-well plate head coming?
87.
by skosuri 9y ago
UC's have an endowment (~$10B), and for UCLA (where I work), the state funds contribute to about 6% of revenues. Tuition is only about 10%.
88.
by skosuri 9y ago
Yes, it really depends on the field. That said in the last 5 or so years there are a lot of early investigator pools of money in biology. This is not true for everyone, but the hard years everyone talks about now is mid-career. I'm not
89.
by skosuri 9y ago
It depends. I'm still under 40, and many of the things he considers mistakes I don't (yet). That said, three of the things on the list I've been able to avoid, and I think it's made the rest easier. 1. I was lucky to get
90.
Ginkgo Bioworks [YC S14] raises $275M on greater than $1B valuation(buzzfeed.com)
2 points by skosuri 9y ago|0 comments

More ›