rgejman

11 ms·

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by rgejman 9y ago
There are other reasons why flu vaccines don't work from year to year. For instance, this year there is evidence that vaccines made in eggs acquired mutations that limited the effectiveness of the immune response ( https://ww
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by rgejman 9y ago
No it is not that simple. You need a carrier to help the DNA get into cells efficiently. If you want to modify specific cell types then you need a cell type-specific carrier. Today, editing your DNA is "easy" -- targeting the righ
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by rgejman 9y ago
I like reading your comments, thinking to myself, "this is something chimeracoder would write" and then seeing that you did in fact write it.
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by rgejman 9y ago
Why was this article flagged?
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by rgejman 9y ago
On #1: I hear you and I think this is a totally valid approach for a society where we don't have little old ladies and gents who lose the piece of paper on which they've written their key and all their friends are old and they urg
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by rgejman 9y ago
I have never understood how blockchain will solve the "I lost my key" problem. I also don't understand how it will solve the "once I gave them access to my data, company X saved a record in a traditional database and now
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by rgejman 9y ago
The replication projects I am specifically referring to are similar to eLife's "Reproducibility Project: Cancer Biology": https://elifesciences.org/collections/9b1e83d1/reproducibili... http:/
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by rgejman 9y ago
While I agree with Kahneman that it is easy to fool yourself by looking at studies with small sample size, the recent focus on reproducing existing research is, to my mind, misguided. It is extremely difficult to perform experiments exactly
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by rgejman 9y ago
I really don't think the proposal to do "fewer, but better" experiments work with animal studies. They are so expensive and so complicated and so much work and only answer singular, small questions that you almost always need
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by rgejman 9y ago
Animal experiments will get A LOT more expensive. Will there be a concomitant increase in agency funding to offset the increased costs?
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by rgejman 9y ago
I have no problem with communism per se and I'm not a reactionary. I'm not sure why you would allege that. I frequently point out problems with scientific topics posted on HN.
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by rgejman 9y ago
What's your point? Newspapers shouldn't treat the subjects they cover critically? They shouldn't contextualize statements to help readers distinguish truth from fiction? They are critical and contexualizing when it comes to c
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by rgejman 9y ago
I really wish the NYTimes didn't publish crap like this: "here's a marginally significant observation about two groups of people and here's a bunch of anecdotes that purport to explain the difference." It's a j
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by rgejman 9y ago
this is the plot of a sci-fi novel waiting to happen.
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by rgejman 9y ago
We have systems like the ones that the author desires (LabGuru, other electronic lab notebooks). However, I don't think the author's premise is well founded. Every scientist dreams of publishing a beautiful, fully formed scientifi
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by rgejman 9y ago
Just a clarifying note: mutations and foreign proteins are not always responsible for the effectiveness of TILs in all cases. For instance, in a report from this year, patients with HPV (Human Papilloma Virus) positive cervical cancer were
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by rgejman 9y ago
Just restricting ourselves to the developed world: Being able to call anyone in the world from your home? Not having to worry about food scarcity? Not worrying about being drafted into an army? Political and technological differences have
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by rgejman 9y ago
>But if you took someone from 1870 and had them wake up 70 years later, in 1940, the world would look entirely different. >Now skip forward from 1940 to 2010: apart from our obsession with little glass rectangles, the world would be f
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by rgejman 9y ago
1. Agreed this is a problem, but it's not unsolvable. A pilot project of peer review as a service could ferret out these issues and come up with solutions. Here's a couple of ideas: (a) let authors give feedback on reviews for edi
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by rgejman 9y ago
Yes to PLoS One. I think Scientific Reports (as a NPG journal) still tries to be somewhat selective, but I'm not sure. My proposal is a bit different because it establishes a preliminary and public review process that is separate from
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by rgejman 9y ago
Agreed. That's why I'm arguing that peer reviews should be handled separately from publication or any consideration of impact.
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by rgejman 9y ago
The fee is designed to offset the real cost of (1) a person making an informed decision about what reviewers to send the manuscript to and (b) the real cost of a reviewer spending 3-4 hours on the manuscript. That ought to be an upfront c
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by rgejman 9y ago
I think about this problem a lot because the whole biomedical publishing industry is so backwards. One of the reasons why scientists are currently dependent on the journal industry is because the journals control peer review. Unfortunately,
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by rgejman 9y ago
My understanding is that people use bitcoin to buy other cryptocurrencies because they can more easily exchange their conventional currencies for bitcoin. As a result, bitcoin demand is maintained at elevated levels.
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by rgejman 9y ago
Agreed and that's my dream commute. I would love bike every morning for an hour.
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by rgejman 9y ago
I've been biking to work every day in Manhattan for about 2 years (~3.5mi each way). I go from 14th to 70th in about 15-18 minutes. I feel healthier and stronger and it has made a difference in every aspect of my life. There are two re
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by rgejman 10y ago
Is it possible that no individual star OR individual cell can be sufficiently described because of quantum uncertainty effects that would affect any "object" with electrons (speaking as a biologist; not a physicist). Also: this is
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The Trump Administration’s War on Science(nytimes.com)
1 points by rgejman 10y ago|0 comments
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by rgejman 10y ago
We will solve the opioid crisis in this country and the solution will almost certainly come through new scientific advances. For instance, a recent study in Nature Medicine[1] showed that you could decouple the positive analgesic (pain re
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by rgejman 10y ago
We already know the major drivers in most tumor types. These are the early mutations that you are going to look for in cell free DNA. Additional cancer-normal pairs are not going to elucidate many new driver mutations. Only careful prospect

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