3 ms·
Just a clarifying note: mutations and foreign proteins are not always responsible for the effectiveness of TILs in all cases. For instance, in a report from thi
by rgejman 9y ago
Just a clarifying note: mutations and foreign proteins are not always responsible for the effectiveness of TILs in all cases. For instance, in a report from this year, patients with HPV (Human Papilloma Virus) positive cervical cancer were treated with TILs. It was expected that most of the TILs would be directed to HPV antigens or mutated protein (neo-antigens) because both would be maximally foreign to the immune system. However, it was determined that T cells against the wild-type protein CT83 (also known as KK-LC-1; which is a wild-type cancer associated antigen) dominated the response in at least one patient.
http://science.sciencemag.org/content/356/6334/200.full http://science.sciencemag.org/content/356/6334/200.full
- dm319 9y agoThanks for that - I'll have to have a look at that when I get back on my network. As you say, there are many reasons why cancer isn't self - neo-antigens are just a facet of that. Are cancer associated antigens the same thing as cancer-testis antigens? To be honest, I've never really groked CTAGs - they don't make sense to me. Why does the thymus not expose T cells to them? Why does cancer produce them? To many questions..!