podgaj

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by podgaj 7y ago
Why am I being down voted for a question? Sorry I am old and new to Hacker News but I have a Phd. Am I doing something wrong?
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by podgaj 7y ago
What about decreasing pulmonary vasodilation? Wouldn't pulmonary hypertension be beneficial here? Is this a role zinc might play? If there is a zinc deficiency would this not lead to vasodialtion and the dilution of the pneumocytes? h
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by podgaj 7y ago
I do not see Heme being directly involved. I feel the mechanism of damage might be mediated through oxidative stress. Possibly through Zinc deficiency and failure of the SOD1 or SOD3 enzymes. https://www.ncbi.nlm.nih.gov/pmc
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by podgaj 7y ago
> should always be suspect. Suspect of what? What bias? I am just talking about science. Bu this is why I am here, to get away from all the credential posturing in academia. You are an MD, are you telling me you cannot commiserate with m
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by podgaj 7y ago
We talk about it often enough... https://www.ncbi.nlm.nih.gov/pubmed/29522710
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by podgaj 7y ago
Anyone else with "credentials" will understand the metabolic pathways enough to have a conversation with me. Sorry, I just do not want to post my credentials for privacy reasons. Asking you now, are you concerned about peroxynitri
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by podgaj 7y ago
I am writing here, where there are lay people, but I am still not writing for lay people. And I am not giving up credentials because if you worked in academia you would know why. No one is an expert on the nutrigenomics of COVID19, not even
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by podgaj 7y ago
So just ignore it if you do not have time. You are obviously not my target audience. But how do credentials help you other than to make you gullible when someone shows you their credentials? I am not saying I am correct and you should take
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by podgaj 7y ago
There are plenty of credentialed people who do not know much or use their credentials to scam people, so it really does not matter. If I posted my credentials everyone would just believe me because of my credentials. I want the ideas to sta
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by podgaj 7y ago
>where does it say black tea increases NO in vivo? Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols* https://www.jbc.org/content/279/45/46637.short >R
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by podgaj 7y ago
I am not stating fact here, just hypothesis. There are both diets and genetics that can tie all these comorbidities together. Just look at zinc and heart disease. I am just posting one study but the evidence is plentiful. https:/&#x2F
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by podgaj 7y ago
> Do you have any background in this, or any understanding of it? Yes, I do. If you want help understanding it just keep asking me questions about instead of trying to tease out my credentials. I am not stating theories, I am only throwi
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by podgaj 7y ago
Smoking will reduce BH4 and that will lower NOS2 activity leading to lower NO. Nicotine on its own will inhibit GCH1 and lower levels of BH4 directly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201367/ So
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by podgaj 7y ago
Yeah, that is fine, but if you are deficient in, or not taking zinc and B2 with it, it is useless. NOS2 needs the cofactors I listed above to function and taking more arginine will just lead to nutrient depletion of those cofactors.
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by podgaj 7y ago
I could go on and on about zinc. ACE2 is a zinc metalloproteinase, contains two zinc ions and uses zinc as a cofactor. Hey, you know, maybe that is why it is good becasue SAARS-CoV-2 happens to drag ACE2 INTO the cell so maybe the zinc it d
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by podgaj 7y ago
But that depends on the amount of oxidative stress you have... " UVA-induced decomposition of the NODs, like nitrite, leads not only to non-enzymatic formation of nitric oxide (NO), but also to toxic reactive nitrogen species (RNS), li
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by podgaj 7y ago
We know now that genetics and lifestyle can alter someones needs for nutrients. So what is good "in general" might not be good for me. https://ghr.nlm.nih.gov/condition/riboflavin-transporter-def... It is not
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by podgaj 7y ago
Neither will help create NO without the cofactors that help the enzymes that make NO. It is like trying to stuff a clogged pipe with more water.
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by podgaj 7y ago
Remember it is also important to control O2-(superoxides) since NO + O2- = ONO−2 (perixoynitrite) And that can lead to higher cytokine levels https://www.jbc.org/content/277/3/2330 which are helpful to a cert
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by podgaj 7y ago
Coincidence? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939908/ Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes
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by podgaj 7y ago
So nutritionally we should be looking at things needed to stimulate the NOS gene (NOS1, NOS2, NOS3): NOS2 cofactors are; Heme, FAD, FMN, and BH4 Zinc - It helps make BH4 through the GCH1 and PTS enzymes from GTP. Riboflavin - it is the prec
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by podgaj 7y ago
"COVID-19 attacks hemoglobin and that is how it damages the lungs." COVID-19 is not the virus, it is a disease cause by SARS-CoV-2. And no, SARS2 does not "attack hemoglobin". The lungs are filled with fluid from an over
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by podgaj 7y ago
This is so wrong I do not know where to start. ADAM17 is responsible for shedding of ACE2 from the cell which creates soluble ACE2. If ACE2 is not ON the cell the virus cannot infect the cell. ADAM17, like ACE2 is a zinc finger protein and
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by podgaj 7y ago
If the patients have a zinc deficient they can make all the zinc channels they want, it won't matter. It is one thing to inhibit the virus, but zinc is needed to reduce the over active immune response,
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by podgaj 7y ago
Can someone explain the dearth of research looking out how zinc deficiency might explain variations in outcome after SARS-CoV-2 infection? Both ADAM17, which helps ACE2 shed from the cell, and ACE2 itself, are zinc finger proteins and use z