pfisherman

7 ms·

61.
by pfisherman 1y ago
I was around for the dot com boom and bust, and this does not feel similar. The issue with the internet was that much of the value came from network effects that were not there in the late 90s and early aughts when personal computing was d
62.
by pfisherman 1y ago
Could this also be attributed to rising interest rates, a giant tax increase (tariffs), and the highly uncertain - err I mean “dynamic” — operating environment caused by the current administration? From my viewpoint, companies are in a soft
63.
by pfisherman 1y ago
Key question is the license they attach to model and weights. I have been seeing an increasing amount of releases in this space under non-commercial licenses. I think companies in the space should either totally open source or not publish a
64.
by pfisherman 1y ago
You would not need much more than 2 megabases. The genome is not one contiguous sequence. It is organized (physically segregated) into chromosomes and topologically associated domains. IIRC 2 megabases is like the 3 sd threshold for inter
65.
by pfisherman 1y ago
You mean Tesla will merge with Twitter / XAI, and market cap will soar to $50T on Elon’s promises of “AGI next year”.
66.
by pfisherman 1y ago
They decided to try to be a pharma company instead of a diagnostics company. The microarray tech was obsolete, but they did have a lot of data. The problem is that being a pharmaceutical company is very difficult. I always question why th
67.
by pfisherman 1y ago
From my uninformed perspective this seem like a rather big and sensible lever toward rebalancing US national finances. The actuarial math must have changed significantly since the inception of the program, no?
68.
by pfisherman 1y ago
See my comment above. Getting approval for rare diseases and expanding the indication to the common form of the disease is a well established strategy in pharma.
69.
by pfisherman 1y ago
Also rare genetic diseases give insight into the underlying mechanisms and pathology of common sporadic diseases, which can be leveraged to develop new and better therapies. Getting a new drug or therapy approved for a rare form of a diseas
70.
by pfisherman 1y ago
So what is the difference between moral ambition and hubris? To me limiting oneself to “idealistic but not ambitious” with a focus on fulfilling relationships and positive impact on family, friends, and local community seems like a good way
71.
by pfisherman 2y ago
Complexity is not just variation in chord progression, key, or melody. Dark Side of the Moon is basically the same chord progression repeated over and over; but with different rhythm, tempo, arrangement for each song. The variation within
72.
by pfisherman 2y ago
Agreed on chord numbers and progression being the analysis that should have been done. For example, blues is mostly defined by a 1-4-5 progression and the ol 2-5-1 is pretty ubiquitous across time and genre. Also, I think disappearance of
73.
by pfisherman 2y ago
Running mechanics also greatly impact injury risk. One of the best suggestions I got was to drastically increase my cadence, which forced me to go from longer (more powerful) strides to shorter (lower impact) strides. My observation is it
74.
by pfisherman 2y ago
> I would never do such a thing, why are you? LOL! Because I wrote a research proposal that was approved, got an IRB, and worked with a team of clinical staff to execute the study. That’s generally what goes on at major academic resear
75.
by pfisherman 2y ago
It all ends up in the EHR, which is a legal document and considered THE source of truth about a patient’s care. Without seeing you hospital IT system I can guess with pretty high certainty that you are getting manufacturer info and model n
76.
by pfisherman 2y ago
Which barcode are you scanning? Are you sure it the right one? Which field is the data from the barcode scan going into? What data is actually deposited into the field? I invite you to do the exercise of tracking implant data of a case yo
77.
by pfisherman 2y ago
Manufactures are required to have UDIs on the label. FDA does not regulate the practice of medicine. Thus they cannot compel hospitals to record UDIs in electronic health records and they do not. Source: I have published articles, organiz
78.
by pfisherman 2y ago
UDI information is not captured at the point of care. Like if you try to go into EPIC at a hospital and query encounters or implantations by UDI it will not return anything. I think that maybe you are having trouble believing that such sim
79.
by pfisherman 2y ago
It is. FDA requires manufactures to display UDIs in packaging (or devices themselves) in human and machine readable format. But hospital IT systems are not set up to capture this information and they have no compelling (i.e. financial) inc
80.
by pfisherman 2y ago
No they don’t. I helped lead a failed effort to implement UDI capture at a major academic research hospital. To date only Duke and Mercy health systems have implemented UDI capture in a limited capacity. The big problem is that implementa
81.
by pfisherman 2y ago
Recalls get issued with reasonable frequency. The crazy part is that clinics have no way of identifying exposures (patients) or inventory impacted by recalls because US hospitals do not capture unique device identifiers (UDIs) in electroni
82.
by pfisherman 2y ago
Simple explanation. Musk has lost it. His long term drug (ketamine) use has resulted in a psychotic break, which we are watching play out publicly.
83.
by pfisherman 2y ago
Another problem with measuring effectiveness that you are relying on patient (or caregiver) reported outcomes. There are no “objective” measurable criteria for depression, such as a biomarker on some lab test or survival at 5 years. Depre
84.
by pfisherman 2y ago
You can argue until you are blue in the face that people should not have interpreted what he wrote as offensive. But in fact a very large number of people did.
85.
by pfisherman 2y ago
I dunno. Could be that the hiring practices at the time, or the team that interviewed him vetted algorithmic problem solving skill and did not run a vibe check on social or emotional intelligence. Because blasting out a company wide post
86.
by pfisherman 2y ago
See the “Rooney rule” in the NFL. Hiring female sports casters, referees, etc.
87.
by pfisherman 2y ago
Basketball is not football. It is a five man game where one player can have an outsized impact. Superstars not only impact the makeup of their teams roster, they impact the composition of rosters across the league. When Shaq was in his pr
88.
by pfisherman 2y ago
This article was written by someone who has very little knowledge or appreciation of the history of the game. The NBA has always been a league of specialists revolving around a few superstars with a couple of “glue guys” thrown into the mi
89.
by pfisherman 2y ago
This year has been a first hand education in the benefits / efficacy of vaccines for my child. Like the differences in outcomes are so stark that the effect of vaccination is obvious to even a young child. I have also heard anecdotes
90.
by pfisherman 2y ago
There was no official shut down here. But the teachers and about 45% of the kids @ child’s grade level were out sick last week. So was definitely not business as usual either.

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