pfisherman

8 ms·

91.
by pfisherman 2y ago
Yes. I know of two people who had breakthrough infections. I had a mild breakthrough myself. Got the brain fog and fatigue but was thankfully spared the fever, cough, and sore throat.
92.
by pfisherman 2y ago
Definitely not paranoia. Near constant respiratory infections are par for the course with grade school aged children. You typically don’t call or visit the pediatrician unless things are especially bad or unusual.
93.
by pfisherman 2y ago
If you know how these algorithms work, and you can be intentional about what you want, seeding with a few well thought out examples, and curating recommendations; they can be quite useful. I think atomic power or even better drugs / me
94.
by pfisherman 2y ago
Is something like automated personalized content creation (for ads) better targeting? Or is it qualitatively different? I personally think that the population scale surveillance and behavioral manipulation infrastructure built by meta is u
95.
by pfisherman 2y ago
> They aren’t going to do basic research. Fixed that for you. Pharma companies do lots research. But the goal of that research is very narrow - to bring new therapies to the market. The Academy has very different goals - train next ge
96.
by pfisherman 2y ago
> The US Economy is pretty vulnerable here. If it turns out that you, in fact, don't need a gazillion GPUs to build SOTA models it destroys a lot of perceived value. I do not quite follow. GPU compute is mostly spent in inference, a
97.
by pfisherman 2y ago
Adding to that — the mission of academic research centers is to train the next generation of researchers. PIs use this money to fund grad student and postdoc positions in their labs.
98.
by pfisherman 2y ago
Given trends in media (social and otherwise) will have to take a wait and see approach. But sudden cancellations with limited communication is definitely not a strong indicator of a well thought out or executed plan. Feel sorry for the youn
99.
by pfisherman 2y ago
I used to do bench top work too; and was blessed with “the golden hands” in that I could almost always get protocols working. To me this always felt more like intuition than deductive reasoning. And it made me a terrible TA. My advice to
100.
by pfisherman 2y ago
This is still on retrospective data. The machine learning graveyard is filled with models that worked well on retrospective data, but did not hold up in a live inference setting. Just ask Zillow. The real test is whether they can predict
101.
by pfisherman 2y ago
> The most significant part of Crick’s idea — and the part that Watson ignored in his oversimplification — was that there are three flows of information that cannot occur, due both to lack of experimental evidence and any plausible bioch
102.
by pfisherman 2y ago
The parent of any young child can tell you that they learn through lots of exploration and reinforcement - often to the worry and chagrin of caregivers. Indeed much of our job is to guide exploration away from excessively dangerous “resear
103.
by pfisherman 2y ago
I am not an expert in the particular application domain of that article; but I can see why their argument of pre training might be valid. It is not especially controversial to say that pre training neural nets improves few shot learning pe
104.
by pfisherman 2y ago
I very much agree with the perspective that LLMs are not suited for “reasoning” in the sense of creative problem solving or application of logic. I think that the real potential in this domain is having them act as a sort of “compiler” lay
105.
by pfisherman 2y ago
How good are our animal models of ALS? Are they predictive of effectiveness in humans?
106.
by pfisherman 2y ago
Prop 13 had a huge negative effect on quality of public schools in California, which I got to experience first hand. The difference was quite apparent to me during high school when I compared my older siblings’ yearbooks to my experience of
107.
by pfisherman 2y ago
Agreed. I was on twitter to discover, share, discuss articles and talks in my field of research. A couple months ago I had trouble finding good accounts and content; but now I am starting to find some of the PIs I was following over on tw
108.
by pfisherman 2y ago
Why use an LLM as opposed to a more narrow purpose built model? LLMs are not beating smaller, purpose built models on tasks like POS tagging, NER, sentiment analysis, etc. And the inference costs scale quite poorly (unless you are self hos
109.
by pfisherman 2y ago
Have people not always been this way? It seems like people forgotten their Emily Post —that it is generally considered a faux pas to discuss controversial topics like religion or politicd outside of intimate social settings with close frien
110.
by pfisherman 2y ago
The “might work” is doing a lot of heavy lifting in this sentence. How strong must the evidence be for the hypothesis of efficacy to be considered reasonable?
111.
by pfisherman 2y ago
So what exactly did the CEO say? Did he attest to tether’s balance sheet? Did he attest to the dollar amount of tether’s assets managed his institution? What I am getting is that he simply said that he holds some of tether’s assets. Why a
112.
by pfisherman 2y ago
What are the incentives at work here? What is their risk exposure to a collapse of tether? What would be the reputation al risk to their firm if tether was a scam? I personally would take this with a grain of salt as they have a direct fin
113.
by pfisherman 2y ago
Also they talk a lot about data centers and cloud compute, but do not mention chips for on decide inference. Given where mobile sits in the hierarchy of interfaces, that is where I would be placing my bets if I were a VC.
114.
by pfisherman 2y ago
Have not read the article in depth yet, but I am very familiar with the Troyanskaya lab. They are good and their articles are always worth a read. They are using a geodesic finite mixture model, which I am not familiar with, but seems to b
115.
by pfisherman 2y ago
I can see the big chip makers making out like bandits - a la Cisco and other infra providers with the rise of the internet. They are facing competition from companies making hardware geared toward that inference that I think will push their
116.
by pfisherman 2y ago
> This definition of success is founded on power and control. I don’t get how this follows from the quote you posted? My interpretation is that successful people create durable, self sustaining institutions that deliver deeply meaningful
117.
by pfisherman 2y ago
Who are you betting on then? Anthropic? Google? Someone else? I mean Microsoft was not the friendliest company. But they were good enough at serving their customers needs to survive and prosper.
118.
by pfisherman 2y ago
The etymological origin of “credit” comes from Latin for believe or trust. Credibility is everything in business, and you can put a dollar cost on it. While banditry can work out in the short term; it pretty much always ends up the same way
119.
by pfisherman 2y ago
Biosci Twitter used to be amazing. Great resource to find cool new articles if you followed the right people. Now it is absolutely useless for that purpose. Such a shame. Death of a golden age.
120.
by pfisherman 2y ago
Not sure we know exactly how valproic acid works. HDACs are like master regulators. Histone acylation is kind of like the opposite of DNA methylation. It is a marker of active transcription. So messing around with these can lead to big e

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