pak

17 ms·

91.
by pak 12y ago
> All cancers use similar mechanisms because of concept known as convergent evolution. First of all, this hypothesis is still highly contested in the literature. There are no doubt certain pathways (usually part of cell cycle regulati
92.
by pak 12y ago
Cancer is the inevitable outcome of aging in a long-lived multicellular organism. It is a fundamental principle of evolution that things that replicate faster and survive better will prevail. We are made of coordinated, replicating cells
93.
by pak 12y ago
> There are no laws of nature that prohibit redundant replication of data There most certainly are, at the information density of DNA. DNA is about a thousand times more information dense than our best hard drives. At that level, a pas
94.
by pak 12y ago
You're getting downvoted probably because people do not understand the raw truth that lies behind what you said. I detest articles that use the word "cure" and "cancer" in the title. They are without fail so breath
95.
by pak 12y ago
I think, for the sake of his challenge (to find one good software patent granted in the last year), he is allowing the challenger to assume that those three other conditions are fulfilled simply because they would be much harder to argue ab
96.
by pak 13y ago
Then forget the FIFO convention. How about a hardware random number generator? However, this doesn't fix the problem with placing and canceling lots of orders to sway the bucket toward the end of the 5-minute window. I suppose if som
97.
by pak 13y ago
Yes, I can believe that is what he is saying. Certain banks/credit cards have relationships with foreign institutions that can cause unexpectedly low fees, given the right circumstances. On top of which, I've found that both Wes
98.
by pak 13y ago
The increasing inequality in access to care is something that concerns me greatly because I see it all the time (I work for a free clinic that supports local residents without insurance) and I fear that it contributes to growing frustration
99.
by pak 13y ago
Disclosure: I'm currently attending medical school in New York. It seems incredibly irresponsible for a doctor to prescribe things based on an internet conversation without a physical exam. You can't auscultate (listen to with a
100.
by pak 13y ago
I found it funny that their current ad, "Don't Back Down", https://www.youtube.com/watch?v=AuXBcbYvKU8 uses an animation at 0:08 clearly from the STAR experiment at Brookhaven National Laboratory http:/
101.
How many fake restaurants are on Seamless?(tribecacitizen.com)
1 points by pak 13y ago|0 comments
102.
by pak 13y ago
For a similar visualization of the human genome, and to get a sense of how vast that landscape is, check out this genome browser I made a couple years ago: http://chromozoom.org At the lowest zoom level, one pixel is 280,000 bp
103.
by pak 13y ago
Assuming you meant "conspicuous", the problem with this idea is that when such officers want to participate in less than stellar behavior, they will obscure the numbers (by putting on a jacket, etc.). This could be justified to t
104.
by pak 13y ago
`highlight = reverse` also flies in the face of TOOWTDI (from PEP 20). Which is a shame, because this means that convenience methods that Ruby has, e.g. ary.first → ary[0], ary.compact → ary.reject{|x| x.nil? }, ary.map → ary.collect are pr
105.
by pak 13y ago
Both the webserver (Apache) and PHP are off by default and have to be enabled separately, the latter by editing a config file. Essentially, only Mac-owning web developers who enable these things (and serve PHP from their box to the world) a
106.
by pak 13y ago
This article's title echoes a paper which continues to influence the medical research and bioinformatics community, "Why Most Published Research Findings Are False" by JPA Ioannidis. http://www.plosmedicine.org&#x2
107.
by pak 13y ago
Yup, I've switched over my Chrome extension [1] to use Algolia's API instead of HNSearch (which is shutting down), and so far, it seems to be working peachy. [1]: https://chrome.google.com/webstore/detail&#x2F
108.
by pak 13y ago
Your hypothesis and the one I floated aren't mutually exclusive. My idea doesn't necessitate a conspiracy or playing with the points/ranking, which PG is rather quick to deny in his reply to me. It could have just been a p
109.
by pak 13y ago
Is this the reason that so many of his recent posts were promoted on here? Was the intention to build the cachet of some widely read essays so he could credibly step in for PG? HN stories for his blog start about a year ago, a little after
110.
by pak 13y ago
You're confusing Ruby and Rails. Ruby is also a general purpose scripting language. The OP was careful to only compare Rails with Django, Ruby with Python.
111.
by pak 13y ago
As you read all these many lines of code to simply find the largest file in a directory, recall that in any language with friendlier blocking/non-blocking semantics, it could be as simple as (e.g. in Ruby) Dir.glob('*')
112.
by pak 13y ago
The more that I use Python in the context of other languages, the more the "there should only be one [obvious] way to do it" mantra irks me. First of all, there's the cases in which reality fails to live up to expectations, l
113.
by pak 13y ago
Yes, it is. Coming to this mess from the joy of bundler/gems, npm, or hell, even CPAN will ruin your afternoon. It is just an unfortunate circumstance of the community not efficiently converging on well designed standards quickly enou
114.
by pak 13y ago
Re: strings, I was referring to what I said already and you quoted only part of it: > It's odd to me that they were willing to break so much code with 3.0 (by "fixing" strings and Unicode) but a couple decorators held this
115.
by pak 13y ago
>@classmethod and @staticmethod are somewhat important language features And strings aren't? Whatever, I understand that there are tradeoffs and to people that only use Python, the aesthetic blemishes tend to matter less. To peopl
116.
by pak 13y ago
It's not flamewar material. GVR himself has acknowledged everything (edit in response to @EdwardDiego: most of what) I said. ( http://neopythonic.blogspot.com/2008/10/why-explicit-self-ha... ) The main conten
117.
by pak 13y ago
>I hate implicit hidden defaults and assumptions. Your implicit hidden default is my handy abbreviation. Imagine if we didn't have contractions in English. For that previous sentence, is it really at all frightening that the "d
118.
by pak 13y ago
> a default GUI framework Tkinter is Python's "default GUI framework". At least, that's what they continue to claim ( https://wiki.python.org/moin/TkInter ), and it's the GUI library I ran in
119.
by pak 13y ago
>The idea to allow one project to switch between Python 2 and 3 for individual files Yes, I believe key parts of the standard object model changed between the two (e.g. strings vs bytes, many of the magic methods and operators) making th
120.
by pak 13y ago
If you're on Chrome (in which case there will be no lasting victories, only small ones), there's this extension: https://chrome.google.com/webstore/detail/iba-opt-out-by-goo... This looks like it does th

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