klmr

37 ms·

301.
by klmr 8y ago
> All you have to do is go to France I’ve lived in France for several years. And yes, I agree that France unduly restricts individual freedoms (and protested against it). I’m not claiming that any single country is perfect. I’m claimin
302.
by klmr 8y ago
> You seem to have intentionally ignored "and its member states." I didn’t, but your comment insinuates that it’s all the same. As for restricted individual freedoms, this betrays a lot about your background. EU contries value
303.
by klmr 8y ago
I’m not — I’m actually contacting my MEP.
304.
by klmr 8y ago
To clarify: I find the UK’s knife ban stupid, and it affects me personally (I often cook at friends’ places and, if these friends have no proper knives, I bring my chef’s knife; I also own two valuable antique swords but the rules for bring
305.
by klmr 8y ago
Art 13 isn’t a EU vs US thing. It‘s a digital vs analog thing (or, more precisely, old-style copyright holders vs young content creators).
306.
by klmr 8y ago
That’s pure trolling: First off, the Article 13 in question was already rejected once by Parliament and is expected to be repealed against (but it doesn’t hurt to be cautious, good on Mozilla). > GDPR While not uncontroversial, GDPR is g
307.
by klmr 8y ago
This is a misunderstanding: “non-profit” does not mean that an organisation can’t earn money. It means the company cannot be sold, and all profits have to be reinvested (rather than e.g. paid out to shareholders). And PLOS, like for-profi
308.
by klmr 8y ago
Why a scam? And why only PLOS but none of the other commercial publishers? But yes, the (well known) profit margins of some of these publishers are quite simply obscene.
309.
by klmr 8y ago
Many researchers at the moment happily pay APCs (=Open Access article processing charges) in the several thousands of dollars — this is way more than is required as a minimal cost of editing. In fact, you can easily hire a freelance edito
310.
by klmr 8y ago
I agree but to be fair the editing done by journals does provide some value: Most researchers, in most fields outside of mathematics, physics and computer science, have rudimentary editing skills at best. Many very good biologists I know
311.
by klmr 8y ago
> a Trump mouthpiece like the NY Post I think you might be confusing something … the NY Post, while being a right-wing tabloid, has been quite outspoken against Trump for a long time.
312.
by klmr 8y ago
… and even if it were a plural the apostrophe would be misplaced.
313.
by klmr 8y ago
No, worst-case complexity of real quicksort is always O(n^2), regardless of pivot choice strategy (even with stochastic pivot choice, although you’d have to get very unlucky to hit that worst case). You can make the average case better or
314.
by klmr 8y ago
> Why the unrelated note? I’m calling it “unrelated” because I’m giving you the benefit of doubt — in other words, I don’t assume you’re an idiot. But, on the other hand, this is a fairly common confusion that was repeatedly made by th
315.
by klmr 8y ago
Both, if I understood what you mean: The GDPR regulation ((EU) 2016/679) contains provisions for legal enforcement, and describes which process and agencies are responsible for that. Whether this actually works, only time can tell. B
316.
by klmr 8y ago
It … can be both?! And given that the stones explicitly warn of catastrophe associated with the drought it doesn’t seem like a too common occurrence. (Also, on an unrelated note, it’s important not to confuse drought (for which there’s prec
317.
by klmr 8y ago
Which is odd, since GDPR isn’t about cookies. Other means of user tracking fall under GDPR too. (To clarify, it wouldn’t be particularly odd if companies were found to violate GDPR; but the selective move from cookies to other technologies
318.
by klmr 8y ago
The difference is that GDPR does have effective enforcement mechanisms, precisely unlike previous laws. Now let’s see if they’ll be applied.
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by klmr 8y ago
It’s totally OK that fines are used as a last resort. As long as they will be used as a last resort.
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How to deal with “Scrooge McDucks” in my fixed-currency-amount game?(gamedev.stackexchange.com)
1 points by klmr 8y ago|1 comments
321.
by klmr 8y ago
… compared to subsequent phylogenetics (we’re all standing on the shoulders of giants, after all). I agree that, at the time, the work must have been (a) mind-numbingly tedious, (b) intellectually challenging. But comparing past papers (inc
322.
by klmr 8y ago
> Was Woese's discovery just "easy"? In a way, yes. It’s widely established that 20th century biologists got to pick the low-hanging fruits. This shouldn’t detract from the sheer genius they displayed. In the specific case
323.
by klmr 8y ago
No, I'm talking about CRISPR/Cas9. For instance, there are experiments knocking out lots of loci simultaneously. I'm not aware of any other gene editing techniques that could be used by here, at least if you want to preserve
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by klmr 8y ago
It entirely depends why you’re modifying it. Introducing a transgene into E. coli can be done much easier than via CRISPR, true. But that’s not the only (or even main) use of CRISPR. I know of several relevant CRISPR experiments perform
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by klmr 8y ago
> no CRISPR involved Please see my follow-up comment: I was able to find the protocol of the kit that the author likely used and it looks like a CRISPR experiment after all. Its description just didn’t sound like it (the actual steps are
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by klmr 8y ago
I think I got it: the plasmids (plural) contain the Cas9 and the gRNA targeting rpsL in the host organisms [1] (plus the DNA template for the homology directed repair). [1] http://www.the-odin.com/crispr-bacterial-guide&#x
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by klmr 8y ago
The post mentions CRISPR in the title and at several points but I can’t actually discern at what step the CRISPR gene editing would have been performed. As described, this mostly resembles a classical transgenic experiment where a plasmid w
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by klmr 8y ago
23andme does collect such data (on a voluntary basis). So lots of their data is annotated with phenotypes. The data is tremendously useful.
329.
by klmr 8y ago
> A pointer is literally a stored memory address, i.e. an integer You’re mixing implementation with definition . A pointer is (usually) implemented in terms of an integer (i.e. its physical representation is a sequence of bytes interp
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by klmr 8y ago
I’m assuming that the author is describing his experience working as a consultant for a software company with a larger team. The article explicitly refers to multiple programmers working on the code base.

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