jfarlow

28 ms·

181.
by jfarlow 9y ago
I'd be happy to chat. Email me at my first name at serotiny.bio. -Justin
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by jfarlow 9y ago
Customers: Researchers and those they communicate with. Specifically those doing early development of novel proteins - antibodies, biologics, CARs, CRISPR, enzymes, bio-materials, bio-sensors, optogenetics, or basic research. We help them
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by jfarlow 9y ago
Always something. Fixed, thanks.
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by jfarlow 9y ago
We have a lot of friends building genetic design software. Each have slightly different focuses. Ours is primarily, and I think uniquely, focused on an abstraction above the DNA itself (protein construct design). We focus on biological fu
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by jfarlow 9y ago
Yes. We have a curated database of protein functions - so we have some idea of the function of new designs. Any designs submitted for manufacture are further screened - both the customer and the design - by both us and the DNA synthesizer.
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by jfarlow 9y ago
Justin here, cofounder of Serotiny. We've built a web-app to make the design and organization of synthetic genetic constructs efficient, cheap and effective. We've built an abstraction layer to enable scientists to build novel gen
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Show HN: Pinecone – Build your own genetically-encoded tools(serotiny.bio)
81 points by jfarlow 9y ago|27 comments
188.
by jfarlow 9y ago
Justin here, cofounder of Serotiny. We've built a web-app to make the design and organization of synthetic genetic constructs efficient, cheap and effective. We've built an abstraction layer to enable scientists to build novel ge
189.
Show HN: Pinecone – Build your own genetically encoded tools(serotiny.bio)
4 points by jfarlow 9y ago|2 comments
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by jfarlow 9y ago
Well, as CRISPR was originally found as a kind of immune system, there do exist a number of anti-anti-Cas9 systems against that evolved alongside it. There are a number of small inhibitors of Cas9 [1] (which themselves could be used to tune
191.
by jfarlow 9y ago
The trouble is a protein's function is tied to to its solvent, and the small molecules it interacts with on timescales orders of magnitude smaller than a protein itself, AND protein complexes up to microns in size can contain strucutre
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by jfarlow 9y ago
For as much as Musk goes back to 'first principles', I am unclear how, from first principles, a metal electrode can healthily and sustainably interface with a living human cell. From first principles the size, material, sensitivi
193.
by jfarlow 10y ago
The various compounds released by the (organic (containing carbon)) explosives can be metabolized by bacteria. And bacterial metabolism is often linked to sensors within the bacteria already - so that the machinery for metabolizing X isn&#
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by jfarlow 10y ago
> Human enhancements needn’t confer superhuman powers. We already have a library of powers demonstrated to us by nature itself. Because the source-codes of most life on earth is written in the same language, porting packages from one or
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by jfarlow 10y ago
yep :) Unfortunately, the dearth of tools means everyone (coming from as many directions) feels like they must rebuild every tool - so there is a bit of a convergence right now - which spreads every tool thin. But the market for 'RNA-
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by jfarlow 10y ago
Curiously the peptide is derived from a histone protein. Histones are the 'spools' around which genomic DNA is wrapped. Histones are found in the nucleus inside dragon cells. There probably should be no bacteria there even under
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by jfarlow 10y ago
It's not a miracle cure, it's just a nicely different way of attacking a problem. It still has tradeoffs - I'm not versed on what they all are, but its tradeoffs are of a different kind than of small molecules. A few guesses
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by jfarlow 10y ago
The peptide of interest has been named 'DRGN1' [1]. The actual full length DRG1 amino acid sequence of DRGN1 if you want to use it: PSKKTKPVKPKKVA As a genetically encoded peptide it has a few advantages over the traditional small
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by jfarlow 10y ago
Just because it's funny - direclty from Vector NTI's FAQ on their webpage, today, in April 2017: 1. When is Vector NTI Advance™ 11.5 available? Version 11.5 was launched on October 15, 2010. 2. Is Vector NTI Advance® 11.5 compatib
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by jfarlow 10y ago
Unfortunately, software has not much advanced beyond where it was ten years ago. There have been a lot of attempts, but the fact is that it's very difficult to see returns on mass-market scientific software - the market is relatively s
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by jfarlow 10y ago
Nice work. Getting all of these tools in one place, in an easy to use way is not always easy. I'm well aware of what goes on behind the scenes to make something like your alignment there as straightforward to use. The tricky part is w
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by jfarlow 10y ago
It looks like (very much like insulin production in vitro) the proteins involved here are highly modified after translation. Some proteins are usable right after they are produced by the ribosome, some require extensive modification to be
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by jfarlow 10y ago
Hard to hold a conversation on HN. If you ever see this comment - I'd love to hear their skepticism :) Email is my first name at my company's domain. -justin
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by jfarlow 10y ago
Turing's paper [1] is pretty impressive. Well before the mechanics of molecular biology were understood, Turing was able to reason out how you could use a 'few lines of (reusable) (biological) code' to produce patterns as so
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by jfarlow 10y ago
Justin here - cofounder of Serotiny. We've been building software to make the design of genetic tools efficient and straightforward. I'd be glad to to answer any questions about the software, it's capabilities, or the tech be
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Show HN: Pinecone – Easily design genetic devices(serotiny.bio)
2 points by jfarlow 10y ago|1 comments
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by jfarlow 10y ago
We use an Ember library of Semantic UI [1] and it's pretty much a drop-in install to get a visually coherent front-end up and running with a minimal amount of redesigning a wheel. It's themeable and pretty extensible on the CSS s
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by jfarlow 10y ago
Looks like cephalopods have useful, active, and conserved ADAR activity that changes an Adenosine to an Inosine in many RNA transcripts. ADAR (Adenosine Deaminase acting on RNA) is a protein that recognizes specific RNA sequences (likely, s
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by jfarlow 10y ago
At the end of the day (century) it should be as straightforward as making beer, an espresso shot, bread or using a fertilizer. The end-products and techniques are quite simple, even ancient. However the search-space to get to those solutio
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by jfarlow 10y ago
That is exactly what we aim to do: - We keep track of how domains have been used before (so as to mitigate if not entirely predict that QC). We are trying to encode that expertise in a way that is intuitive and frictionlessly sharable. T

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