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Justin here, cofounder of Serotiny. We've built a web-app to make the design and organization of synthetic genetic constructs efficient, cheap and effective. We
by jfarlow 9y ago
Justin here, cofounder of Serotiny. We've built a web-app to make the design and organization of synthetic genetic constructs efficient, cheap and effective. We've built an abstraction layer to enable scientists to build novel genetic designs from functional units without worrying about the actual underlying DNA sequence or how the sequence gets manufactured. Once designed, we help you place an order for DNA from a synthesizer of your choice.
The app is free to use - go ahead and register. We charge 15% of the manufacturing cost once an order is placed. Design single protein constructs, or high-throughput combinatorial sets of proteins or mutation sets. [1]
Our genetic management infrastructure makes it straightforward to see where particular designs came from and how they've been used. It straightforwardly keeps track of the functions and restrictions of each design. For groups/labs we have an API that can respond to queries relating various protein constructs by things like function, sequence, or usage. [2]
Check it out, I'd be curious your thoughts. I'm happy to answer any questions.
We built it all with Go and Ember - a huge thanks to those in the community working on those tools.
[1] https://serotiny.bio/notes/support/tutorials/ https://serotiny.bio/notes/support/tutorials/
[2] https://serotiny.bio/notes/applications/ https://serotiny.bio/notes/applications/
And a few write-ups/dissections of proteins of interest to HN: https://serotiny.bio/notes/proteins/ https://serotiny.bio/notes/proteins/
- atemerev 9y agoWhoa, cool! Do you have any biosecurity-related protection mechanisms in place?
- jfarlow 9y agoYes. We have a curated database of protein functions - so we have some idea of the function of new designs. Any designs submitted for manufacture are further screened - both the customer and the design - by both us and the DNA synthesizer.
- mchannon 9y agoWish I had a use for this- looks really well-put-together. That said, you'll probably want to fix the spelling for "vendors" on the main page (it's misspelled 'venders').
- jfarlow 9y agoAlways something. Fixed, thanks.
- sushid 9y agoGoing back to the previous page to https://serotiny.bio/api/parts/:id https://serotiny.bio/api/parts/:id results in a page displaying the JSON response instead of the normal webpage. ( e.g. go to https://serotiny.bio/api/parts/11236 https://serotiny.bio/api/parts/11236, click 'edit in Pinecone', press cmd + [ ).
- jfarlow 9y agoInteresting... I will need to figure that out. I've not seen that before. The HTML for the page is just a formatted response from our API server formatted by Go's internal templating engine. The back button seems to request something differently somehow. Thanks for catching that. More work :)
- daveguy 9y agoAre there any protein expression systems associated with the DNA product, or is that part left completely up to the customer?
- jfarlow 9y agoWe have built the infrastructure to design out entire plasmids - within Pinecone you can build 'non-coding Cassettes' that include all sorts of expression components. You can build designs that include all the standard DNA expression components - promoters, terminators, recombinase sites, etc. as well as incorporate the proteins to be expressed. We have not focused as much on building out variation in the design of the expression systems, but it is something we are actively working on making nicer. In general, at least so far, our customers have had their own plasmids they're used to working with, or the generic expression systems offered by the DNA synthesizers have been sufficient.