iskander

24 ms·

241.
by iskander 5y ago
I think that you have very succinctly captured the difference between web2 and web3 ideologies.
242.
by iskander 5y ago
I think this why there is an increasing trend towards valuing NFTs which assign rights to the NFT owners or simply license the whole project as CC0. That removes the dichotomy between on-chain ownership and legal ownership and leaves only a
243.
by iskander 5y ago
There's an interesting social consensus that seems to emerge around provenance and originality of NFT contracts. Some NFTs are extremely valuable (e.g. Crypto Punks) and attract many clones. The clones may be on the same blockchain and
244.
by iskander 5y ago
As someone with ambivalent interest in crypto, it seems like a Tether meltdown might be healthy for the space. It would wash out a lot of the accumulated speculative value and hopefully lead to a much more confident regulatory framework fo
245.
by iskander 5y ago
Wow, you're right, USDT is much more prevalent in the largest markets than I would have suspected. Is this a first mover effect? As far as I can tell USDT is the shakiest and least compelling stable.
246.
by iskander 5y ago
>a majority of exchange trading pairs are between currencies and USDT. (not financial advice) Is that actually true? In my (limited) experience I have seen ETH and USDC much more frequently than USDT. There also seems to be a recent migr
247.
by iskander 5y ago
They use a shrinking pool of non-KYC off-ramps, recently they have been having worse luck at staying anonymous and their centralized exchanges are getting shut down. The era of crypto for ransomware is ending, the anonymity of the blockchai
248.
by iskander 5y ago
"designed so that there can be never be criminal justice consequences for any financial action" I don't see why that's true at all, cryptocurrencies are public ledgers with mostly KYC'd on/off ramps. You can pu
249.
by iskander 5y ago
Personally, if not for the real world resource usage, I would be extremely supportive of cryptocurrencies replacing the traditional financial system for reasons that overlap with your reasons for opposing crypto. Essentially, the financial
250.
by iskander 5y ago
>If you're claiming something that hasn't been demonstrated through peer-reviewed scientific research, That's not how science has worked, especially in this pandemic. Most of what we know about SARS-CoV-2 came to us throug
251.
by iskander 5y ago
The article is a good read but the comments here are below what I remember being the quality standards of news.yc; has this place declined?
252.
by iskander 5y ago
>A good artist with nothing else can expect to sell a custom painting for $1k, tops. That's not really right, my wife is a painter without gallery representation who sells in $5k-$12k range. Through her I've met many other peop
253.
by iskander 5y ago
Many market places have an optional royalty to send a percent back to the artist on every sale.
254.
by iskander 5y ago
I think non-crypto coverage of NFTs conflates a few different categories. There's a lot of stuff for sale on more niche venues like Hit et Nunc that's really just art made in a classically recognizable way; people don't flip
255.
by iskander 5y ago
First one I pulled up I recognized as actually existing. Seems like they need a blacklist of real chemicals?
256.
by iskander 5y ago
It's primarily a subsidy for American weapons manufacturers (from whom the Israelis have to make purchases), mixed with a hefty R&D budget for new military technology like Iron Dome.
257.
by iskander 6y ago
High accuracy long read DNA sequencing. The new chemistry for Oxford Nanopore is getting close to where you can use it exclusively without polishing (down to ~1 in 100 base errors), and the price per gigabase has become competitive with Ill
258.
by iskander 6y ago
As an academic, it's really surprising to see people describe the C++ language cabal as academia. Like, no one is getting tenure for dumping more language features into that witch's brew.
259.
by iskander 6y ago
>take[1] some mRNA[2], inject it [3], have in translated as the antigen in the body[4]. Poof, that's it. 1) Develop synthesis technique for large scale high purity mRNA without base errors or truncations. 2) Discover pseudouridine m
260.
by iskander 6y ago
It depends complete on what kind of virus it is. All of the interesting research required to hit "print" on mRNA-1273 was already done in MERS. It would have been surprising if the vaccine didn't work. If a new pandemic emerg
261.
by iskander 6y ago
I did a summer internship at Google in 2009. The "don't be evil" ethos was clearly on the decline as it stood in the way of several major business directions.
262.
by iskander 6y ago
It's certainly a...peculiar...belief system.
263.
by iskander 6y ago
Can someone tell me more about the ideological (theological?) assumptions underpinning these questions? They seem to come from a very peculiar understanding of "social impact".
264.
by iskander 6y ago
The genes essential for cancer cells to grow in vitro could easily be quite different from those required to establish the tumor micro-environment, invade new tissues and fight off the immune system. They'll have many false negatives f
265.
by iskander 6y ago
That's a good summary but it's missing the context that these kinds of "hits" will most likely fail clinical trials. Many drugs look good at this stage in preclinical development and almost none of them show both safety
266.
by iskander 6y ago
Re: monotherapies. This hasn't been my experience. Almost all chemotherapy regimens are combination cocktails (e.g. R-CHOP, CMF, FOLFIRINOX, &c) And as soon as a drug is shown to be very potent on its own (e.g. aPD1/aPDL1 chec
267.
by iskander 6y ago
Drug repurposing for cancer is a neat and vaguely plausible idea that's been eating up attention and grant funding for a decade now, without any successes in clinical trials.
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by iskander 6y ago
I didn't watch more than a few minutes, too much real research going on to keep up with the more fringe stuff. But tl;dr it could be a lab escape but most virologists think it's more likely to be spontaneous zoonosis. In either ca
269.
by iskander 6y ago
Sure, what's your degree of bio background?
270.
by iskander 6y ago
It's not just weak, it's incoherent and seemingly written by someone who misunderstood some wikipedia articles on virology. There's a difference between someone trying to seriously assess the possibility of lab origins for SA

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