2 ms·
>take[1] some mRNA[2], inject it [3], have in translated as the antigen in the body[4]. Poof, that's it. 1) Develop synthesis technique for large scale high pu
by iskander 6y ago
>take[1] some mRNA[2], inject it [3], have in translated as the antigen in the body[4]. Poof, that's it.
1) Develop synthesis technique for large scale high purity mRNA without base errors or truncations.
2) Discover pseudouridine modification to decrease innate immune response.
3) Discover and optimize lipid nanoparticles for encapsulation of mRNA to prevent its degradation.
4) Optimize LNPs and miRNA sites in UTRs for localization to desired cell type and to prevent aggregation in undesired or dangerous cells/organs.
Poof, that's it!