flobosg

49 ms·

751.
by flobosg 5y ago
Sure! It is very rudimentary and some values are still hardcoded, but I could do bit of clean-up and then upload it. EDIT: Here it is – https://github.com/flobosg/journalert
752.
by flobosg 5y ago
To name a few: * A script that emails me every day a list of new articles published by a selection of academic journals. Using an RSS reader for this turned out to be too messy. * A script that generates Spotify playlists based on my liked
753.
by flobosg 5y ago
> is it possible to a priori determine if a protein is ID or ordered? There’s software that attempts to predict intrinsic disorder based on sequence alone, but in general, in the absence of homolog (evolutionarily related) proteins with
754.
by flobosg 5y ago
To be fair, they have published a few papers and preprints related to the topic. See e.g. https://www.pnas.org/doi/10.1073/pnas.2016239118 and https://www.biorxiv.org/content/10.1101/2021
755.
by flobosg 5y ago
Both measures can be quite similar. Most protein designs can be screened in parallel for solubility and successful designs can be further engineered and tested in a high-throughput manner.
756.
by flobosg 5y ago
If I recall correctly, the difference between Architecture and Topology in CATH is that the former is independent of connectivity. > For me, the 'fold' is what happens after 'folding' occurs, but I take the point that
757.
by flobosg 5y ago
> The most accurate term would probably be "tertiary structure". There’s an AlphaFold variant that can predict quaternary structure: https://www.biorxiv.org/content/10.1101/2021.10.04.463034v2 > Th
758.
by flobosg 5y ago
> I found it interesting that AlphaFold can't reliably predict the structures for mutations that disrupt structure It’s not that surprising given the conceptual background of the method. Since it’s relying on evolutionarily couple
759.
by flobosg 5y ago
> 20% is not that great but it has potential. 20% success rate is in line with other protein design methods, though.
760.
by flobosg 5y ago
There are other terms analogous to “fold”, like “topology” (as used in CATH), but they will probably never see widespread use.
761.
by flobosg 5y ago
“Protein fold” and “protein folding” are two different concepts. Folds are structural categories, folding is the biophysical process. But I agree that there are better words out there to name such a tool.
762.
by flobosg 5y ago
> his 'you fool' bit during Hollywood Squares Here it is: https://www.youtube.com/watch?v=WM-3QDQGmHo
763.
by flobosg 5y ago
> It's like Stumbleupon has been reborn! My thoughts exactly.
764.
by flobosg 5y ago
> Don Miguel translations of RPG Maker (…) is how I got into programming. Same here, but I never finished any game. I spent most of my time dissecting other people’s projects and engines. With some creativity you could do impressive stuf
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How to Hack a Game Boy Camera to Use ‘Real’ Camera Lenses(petapixel.com)
2 points by flobosg 5y ago|0 comments
766.
by flobosg 5y ago
That demake brought to mind Warlocked, an RTS game for the Game Boy Color: https://www.youtube.com/watch?v=lSJ5oOmZnbE
767.
by flobosg 5y ago
If you like Albini’s writing you might be interested in the cooking blog he penned for a while some years ago: https://web.archive.org/web/20180125095923/http://whatimadeh...
768.
by flobosg 5y ago
One of the authors, Dan Graur, has a blog where he discusses evolution and junk DNA, among others: https://judgestarling.tumblr.com/
769.
by flobosg 5y ago
The album is 10,000 Days , by the way.
770.
by flobosg 5y ago
The Trackmania expose is mentioned at the end of the article: https://kotaku.com/trackmania-cheating-scandal-is-utterly-fa...
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by flobosg 5y ago
> the other meaning of spleen TIL; and of course it is derived from Hippocrates’ theory of humors…it all makes sense in retrospect!
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by flobosg 5y ago
Not exactly the same, but in the 80s a woman without a vagina got pregnant by a stab in the abdomen shortly after having oral sex with her boyfriend.
773.
by flobosg 5y ago
What a plot twist! Thanks for sharing.
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by flobosg 5y ago
The actual paper: https://www.nature.com/articles/s41591-022-01735-0
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by flobosg 5y ago
He also illustrates the Molecule of the Month section of the PDB ( https://pdb101.rcsb.org/motm ), which highlight different proteins. As as sidenote, his depictions of proteins are usually rendered using a Fortran program he
776.
by flobosg 5y ago
I think that GameFAQs needs to be mentioned. The walkthroughs there used ASCII in creative ways to represent tables, maps, headers, title art[1], etc. [1]: https://www.rockpapershotgun.com/remember-how-great-ascii-ar...
777.
by flobosg 5y ago
“Somewhere in La Mancha, in a place whose name I do not care to remember,…”
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by flobosg 5y ago
Check out https://en.wikipedia.org/wiki/Late_bloomer#Mathematics
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by flobosg 5y ago
> Mathematicians, a different breed entirely, had Leonhard Euler and Carl Friedrich Gauss who kept going until a very old age, for their times—76 and 77—despite starting very early, as mathematicians seem to do. This is not a universal t
780.
by flobosg 5y ago
“Muchos años después, frente al pelotón de fusilamiento, el coronel Aureliano Buendía había de recordar aquella tarde remota en que su padre lo llevó a conocer el hielo.” ―Gabriel García Márquez, One Hundred Years of Solitude Many years la

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