> is it possible to a priori determine if a protein is ID or ordered? There’s software that attempts to predict intrinsic disorder based on sequence alone, but

> is it possible to a priori determine if a protein is ID or ordered? There’s software that attempts to predict intrinsic disorder based on sequence alone, but in general, in the absence of homolog (evolutionarily related) proteins with known structure you would still need to check experimentally for disorder. EDIT: > if the goal is to reliably assess certain viral proteins as ID or ordered, experimental methods are the only methods for achieving this? If you don’t find homologs with solved structures, experimental characterization is the way to go.