> I found it interesting that AlphaFold can't reliably predict the structures for mutations that disrupt structure It’s not that surprising given the conceptua

> I found it interesting that AlphaFold can't reliably predict the structures for mutations that disrupt structure It’s not that surprising given the conceptual background of the method. Since it’s relying on evolutionarily coupled residues, AlphaFold is looking at sets of complementary mutations that keep or rescue a determined structure, i.e. the complete opposite of structural disruption. > The list of protein structures we know isn't a representative sample of all possible protein structures And the same goes for protein sequences.