flobosg

17 ms·

271.
by flobosg 2y ago
Input MSAs are generated with jackhmmer and HHblits and further processed, if I recall Alphafold’s paper correctly.
272.
by flobosg 2y ago
If non-synonymous mutations do not change the biophysical features of the amino acid residues, then the structure is usually kept. Alternatively, it can be the case that a disruptive mutation is compensated by another one that keeps the str
273.
by flobosg 2y ago
You’d be surprised by how many failures you get by such an approach. Hydrophobic cores can be easily disrupted by altering some side chain volumes.
274.
by flobosg 2y ago
This is already a well known fact: protein structure (and consequently function) is much more conserved than sequence, mostly due to biophysical constraints.
275.
by flobosg 2y ago
Proteins from the same family (and thus the same fold) can share less than 10% identity and still keep the same functionality as shown by e.g. profile Hidden Markov Model comparisons.
276.
by flobosg 2y ago
> However, its amino-acid sequence is vastly different, matching less than 60% of the sequence of the most closely related fluorescent protein in its training data set. Not to downplay this achievement, but 60% sequence identity is nowhe
277.
by flobosg 2y ago
Related, from earlier today: https://news.ycombinator.com/item?id=40941219
278.
by flobosg 2y ago
Here’s a study from 2015: https://www.sciencedirect.com/science/article/pii/S221112471...
279.
by flobosg 2y ago
https://en.wikipedia.org/wiki/List_of_human_disease_case_fat...
280.
by flobosg 2y ago
Related discussion, from last week: https://news.ycombinator.com/item?id=40859876
281.
by flobosg 2y ago
https://www.asale.org/damer/murra
282.
by flobosg 2y ago
> Basically, I’m not interested in doing research and I never have been, I’m interested in understanding, which is quite a different thing. ―David Blackwell
283.
by flobosg 2y ago
Only the abstract/Zusammenfassung is dual-language, as it is usual with German dissertations written in English.
284.
by flobosg 2y ago
> a few food names are not "language influence" in any seruous way Your conclusion is then that Chilean Spanish has no Quechua language influence in any serious way? > the only linguistic legacy of Germans in Chile are kuch
285.
by flobosg 2y ago
> Modern German itself has many weirdly used English words without any immigrants to bring them in the first place. This is correct. Case in point: Beamer . > A few food names do not qualify as "influenced the dialect" for
286.
by flobosg 2y ago
> It's just one of the many English loanwords present in modern languages. Which other modern language uses cachái , with the same spelling, in the same context as Chile? > I can't recall any other German loanwords aside fr
287.
by flobosg 2y ago
> Neither German nor others were numerous enough to influence the Chilean dialect I’ll just say: kuchen , cachái .
288.
by flobosg 2y ago
I was reminded of this comment exchange from last May: https://news.ycombinator.com/item?id=40439379#40440171 . TIL that, according to this paper, antisense treatment in the brain has some drawbacks: > Treatment of mice w
289.
by flobosg 2y ago
In Chile: * auto : car * coche : stroller or carriage (depending on context) * carro : cart or carriage (see above)
290.
by flobosg 2y ago
> here's a random news segment Where the announcer is actually overpronouncing while still keeping (expectedly) some elision. In your example, Boric’s formal register is closer to what one would usually listen. > chileans are ok
291.
by flobosg 2y ago
The country is still polarized to some extent so YMMV, depending on who you spoke with.
292.
by flobosg 2y ago
Sure, that is largely true. But, to state that the formal register of Chilean Spanish is “probably one of the most understandable ones, accent-wise” of all available Spanish registers is, in my humble opinion, quite a stretch.
293.
by flobosg 2y ago
That guy is an asshole, man.
294.
by flobosg 2y ago
What made you reach that conclusion? I’m just curious.
295.
by flobosg 2y ago
> I assume maybe the other one is to align more closely with Argentina or something? It has to do with differences in latitude. In winter, the southernmost region of Chile[1] was completely dark at around 4 PM with the old time zone. Sta
296.
by flobosg 2y ago
This idea is somewhat prevalent among native Chilean speakers, but I respectfully disagree. Even under formal settings, many of the features of colloquial Chilean variants are present, and often an additional effort to neutralize the accent
297.
by flobosg 2y ago
While that might be true, Chile is a very centralized country, unfortunately.
298.
by flobosg 2y ago
Everybody forgets Easter Island! (And the other one in the Magallanes and Chilean Antarctica region was added not long ago, 2017 IIRC.)
299.
by flobosg 2y ago
Should’ve put it in that other meme collection thread!
300.
by flobosg 2y ago
Or by burning it: https://en.wikipedia.org/wiki/Torres_del_Paine_National_Park...

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