eggie

9 ms·

31.
by eggie 8y ago
After switching back and forth between Dvorak and QWERTY for multi-hour work sessions maybe three times I found that I could do so instantly. I learned touch typing on QWERTY very young so maybe this is why it was easy for me. I often use a
32.
by eggie 8y ago
Did you consider using an isomorphic layout like the typematrix? I find the anachronistic skew in keyboards to be a source of discomfort.
33.
by eggie 8y ago
The author doesn't even learn dvorak before deciding that it doesn't work for them. They mention don't like how it behaves on the consonant-heavy, qwerty-optimized commands used in unix. (I have to say this is a fair evaluati
34.
by eggie 8y ago
The genome is akin to the software of an organism. It's not exactly obfuscated, so we can actually learn a lot just by reading it. The next big benefits are all about relating the genome of one organism to others. A single "refere
35.
by eggie 8y ago
No. You need a wheat cell as well. Then you might be in business. And, no, it is not possible (today) to rebuild a multi gigabase hexaploid genome. The best that's been done so far is mycoplasma (500kb genome, which is many orders of m
36.
by eggie 8y ago
I look for all of these things as well, and they are critical. But none of them have any relevance in a technical domain if the person who has them isn't capable of pulling more weight than anyone else. Management is only approximately
37.
by eggie 8y ago
In my experience it is rarely enough to just "lead" more thoughtfully, which seems to be what the author here is promoting. Software development does not just require servant leaders in the helping sense, but in the working sense.
38.
by eggie 8y ago
Using this on an OLED screen really makes it clear that the current standard of light backgrounds and dark text is only optimal with backlit LCD panels.
39.
by eggie 8y ago
Any 3-color screen will never be true to life accurate. It's always a simulation of the real thing projected into the three dimensions of color that most of us perceive. Colors appear to change dramatically under different lighting con
40.
by eggie 8y ago
It's no worse than on a phone. I've never noticed burn in on any OLED phone or my current laptop (although the latter is newer). I'm using a thinkpad X1 yoga OLED. The biggest danger with this device is using Windows, as the
41.
by eggie 8y ago
For personal red illumination I use USB-rechargeable NightRider rear bike lights. I ultimately got two and I take them everywhere with me. They are great night lights, especially when travelling, except for the fact they flash blue when you
42.
by eggie 8y ago
Ubuntu 18.04 has a night mode built into the gnome shell. It works really well, allowing a complete removal of blue. But neither of these has any point if you have blue light bleeding through from the LED backlight of the LCD screen. The mo
43.
by eggie 8y ago
After realizing the effect that blue light had on my sleep I went on a crusade to eliminate it from my life after sundown. I used red LED bike lights for room illumination until I found a series of alternatives. The cheap, remote-controllab
44.
by eggie 8y ago
I've watched many of my and coworkers spending huge amounts of time (many hours a month) fiddling with the complexities of managing software packages on OSX systems. Everything was so frighteningly manual and impossible to reproduce. T
45.
by eggie 8y ago
It's nice when things fit in RAM. But very often they don't. When you want to sort arbitrary-sized binary records on disk look no further than bsort: https://github.com/pelotoncycle/bsort
46.
Variation graphs for efficient unbiased pangenomic sequence interpretation(youtube.com)
2 points by eggie 8y ago|0 comments
47.
by eggie 8y ago
I had the same kind of problem. For me resolving the issue was as simple as learning and using the dvorak layout. Having a different and entirely more efficient way to type completely resolved the problems I was having. This in combination
48.
by eggie 8y ago
Your exposition of Dawkins' ideas is neat, and probably helpful to people in an introductory biology course. I'd like to help clarify some of your comments on the genome. > Even your DNA is not really a unified whole, it's
49.
by eggie 9y ago
What reference model do you align the RNAseq against? That would seem to have a huge effect on results no?
50.
by eggie 9y ago
Would this allow rapid realignment of the data against a given reference (graph?) model? Or is the alignment somehow baked in?
51.
by eggie 9y ago
> certain DNA bases can shape-shift for a thousandth of a second, transiently morphing into alternative states that can allow the replication machinery to incorporate the wrong base pairs into its double helix I find this fascinating. I
52.
by eggie 9y ago
Software is only 1% of the story. We need reliable public data from many people linking genomes, diet, life history, and phenotype to do the other 49%.
53.
by eggie 9y ago
That seems expensive. I got a personal sequence done (at 15x) four years ago for 750 usd. It was part of a group deal so maybe it isn't relevant to your search.
54.
by eggie 9y ago
The technology really works and is generating results at a rapid pace. This will absolutely not be the next Theranos, although you may be right that there are issues of burnrate and maybe even mismanagement. To me the fact that they have a
55.
by eggie 9y ago
The per base error rate is bad. In the case of pacbio, this error process approximates white noise, and so you can deal with it perfectly by increasing read coverage. Things are somewhat complicated with the nanopore tech described in this
56.
by eggie 9y ago
I've participated in several large projects that worked to detect SVs from short reads in humans. The results, which remain best of class, are simply disappointing. A tiny fraction of the variants detected were actually resolvable to n
57.
by eggie 9y ago
> you can get a full human genome sequenced at high coverage for between 1000 and 3000 USD This is not a "full" human genome, but a collection of 150bp fragments that can be realigned to an existing human genome. You cannot tak
58.
by eggie 9y ago
This is the elephant in the room. It definitely seems that something is up when $100M in tokens flow into exchanges and the price immediately jumps. I am trying to find moderate-resolution market data to evaluate the effect that Tether issu
59.
by eggie 9y ago
When I was young and impressionable I repeated some of his crazier assertions in public. I regret it to this day. I'm impressed at his staying power in the public discourse about tech despite how incredibly wrong he has been.
60.
Do Social Networks Need Companies?(weblog.masukomi.org)
2 points by eggie 9y ago|0 comments

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