dunk010

14 ms·

1. 121.▲
   by dunk010 9y ago

   Except that currently genomics requires even more information to be encoded - such as quality scores, allele frequencies, phase information, ... - so, depending on the format, this estimate is off by either one or two orders of magnitude st
2. 122.▲
   by dunk010 9y ago

   Most developers think of the genome like a big load of source code, and if only we could work out where the if and for statements were we could read it. This is an extremely naive and overconfident point of view; the analogy between source
3. 123.▲
   by dunk010 9y ago

   Absolutely dead wrong. It's 2.5Gb, where Gb = Giga bases . Learn you a genomics, son. https://www.nature.com/nature/journal/v420/n6915/full/nature...
4. 124.▲
   Putting strings into databases and then taking them back out again(medium.com)

   2 points by dunk010 10y ago|0 comments
5. 125.▲
   Updated version of the Chain of Fools experiment now with Windows 8/8.1/10(youtube.com)

   3 points by dunk010 10y ago|0 comments
6. 126.▲
   by dunk010 10y ago

   This is basically clickbait. Pretty much all the comments have the same sentiment: $425M is a lot of money.
7. 127.▲
   by dunk010 10y ago

   Citation?
8. 128.▲
   by dunk010 10y ago

   > There are valid reasons that long established companies such as Google, Twitter, Facebook and countless others chose MySQL as their primary data store. I think you're misrepresenting things here. While all do use MySQL for some sp
9. 129.▲
   by dunk010 10y ago

   There's a good article from 2001 which explains this in depth: http://www.cdmasteringservices.com/dynamicrange.htm
10. 130.▲
    by dunk010 11y ago

    Or IRC.
11. 131.▲
    by dunk010 11y ago

    Landlord gets paid twice? Nice work if you can get it!
12. 132.▲
    by dunk010 11y ago

    I'm sure this guy sneers at people who fall for Nigerian Prince emails, but he basically did the same thing. He allowed his own greed to cloud his judgement.
13. 133.▲
    by dunk010 11y ago

    Actually there are armies of experts keeping this all up to date, and some companies make a lot of money selling this as a service. The name of the role is "curator", and they basically map research to genetic variants, keeping a
14. 134.▲
    by dunk010 11y ago

    Yes indeed. And new tools are being written - see the Adam project for an interesting example: https://github.com/bigdatagenomics/adam and the associated variant caller Avocado: https://github.com/bigda
15. 135.▲
    by dunk010 11y ago

    Paul Allen is well known to have one of the largest super-yachts in the world. I'm not sure Ballmer even has one.
16. 136.▲
    by dunk010 11y ago

    I read this as "NSA data API" and it took me a full 5 seconds of staring, eyebrows raised, at the astronaut to realise my mistake.
17. 137.▲
    Programming is terrible – Lessons learned from a life wasted(youtube.com)

    4 points by dunk010 12y ago|0 comments
18. 138.▲
    by dunk010 12y ago

    By stopping reading Hacker News.
19. 139.▲
    by dunk010 12y ago

    Thanks for sharing! Lots of great information in here. I've been a hiring manager for a role more than once and I can attest that it's all true. It would be nice if more people made CVs as easy to read as the tips here would produ
20. 140.▲
    by dunk010 12y ago

    Hardly. There's a lot of great information in the presentation which is applicable to all developers.
21. 141.▲
    Big Data helped Germany in historic win over Brazil(blogs.wsj.com)

    2 points by dunk010 12y ago|0 comments
22. 142.▲
    Wall Street's Lessons for Tinder and the Rest of Silicon Valley(businessweek.com)

    3 points by dunk010 12y ago|0 comments
23. 143.▲
    by dunk010 12y ago

    Thanks for that. I had this strong feeling that this was very much basically the same as something (classic) that I had read before.
24. 144.▲
    by dunk010 13y ago

    "that resulting shenanigans might be a little asymmetric. " - What does this statement even mean? You should think before you just throw a load of cliches into a sentence.
25. 145.▲
    by dunk010 13y ago

    And if you know your phone is stolen you can disable it anyways.
26. 146.▲
    by dunk010 13y ago

    That link doesn't work.
27. 147.▲
    by dunk010 13y ago

    The streaming services don't make money either. In fact, Spotify makes a loss. A substantial loss. An eye-watering loss [1]. And so does anybody else who tries to get into this business. The trail is becoming littered with the corpses of pl
28. 148.▲
    by dunk010 14y ago

    Here's a really great presentation I found (probably on HN) some years ago. http://www.ukuug.org/events/linux2003/papers/bash_tips All extremely useful, my favourite being the .inputrc rebindings of up and down to search history. Takes a
29. 149.▲
    by dunk010 14y ago

    This is the best tip ever.
30. 150.▲
    by dunk010 14y ago

    Very true. Options pool != stock the founders have. There are often many classes. It's never simple.