Yes indeed. And new tools are being written - see the Adam project for an interesting example: https://github.com/bigdatagenomics/adam https://github.com/bigdat

Yes indeed. And new tools are being written - see the Adam project for an interesting example: https://github.com/bigdatagenomics/adam https://github.com/bigdatagenomics/adam and the associated variant caller Avocado: https://github.com/bigdatagenomics/avocado https://github.com/bigdatagenomics/avocado. Others are also trying to get the old tools working on Hadoop, for instance Halvade: https://github.com/ddcap/halvade/wiki/Halvade-Manual https://github.com/ddcap/halvade/wiki/Halvade-Manual, Hadoop-BAM https://github.com/HadoopGenomics/Hadoop-BAM https://github.com/HadoopGenomics/Hadoop-BAM, SeqPig: http://seqpig.sourceforge.net/ http://seqpig.sourceforge.net/, and the guys at BioBankCloud: https://github.com/biobankcloud https://github.com/biobankcloud. It's going to take quite a while for this stuff to get fleshed out, and for researchers to adopt it. But the sheer weight of data is going to force things in the Hadoop direction eventually. It is inevitable.