dm319

15 ms·

151.
by dm319 4y ago
And what interpretation of 'absurd in the extreme' should we take?
152.
by dm319 4y ago
Wasn't there something about Elon trying to sell Twitter stock privately? I think in the financial times. They have probably lost a lot of advertisers, and Elon might be in financial trouble.
153.
by dm319 4y ago
> I don't buy into all the freedom of speech rhetoric he has been spewing. I think what you meant was you didn't buy into it, and this is proving your point of view. He's gone from freedom of speech absolutionist to defini
154.
by dm319 4y ago
Even worse, does it apply any ethical principles to the decision making around the limits of freedom of speech? I.e. when you're weighing up whether, say, incitement of violence, or Nazi support are beyond the line of what is acceptab
155.
by dm319 4y ago
Ok, what do you think of that rule?
156.
by dm319 4y ago
I'm curious - I've seen his tweet. Can I ask you: 1. Are you just an advocate for following a website's terms? 2. Or do you think there is credibility in these terms?
157.
by dm319 4y ago
Honestly, I care less about 'fixing' something so it is profitable, and more about what ethical compass people are using to make their decisions. A couple months ago it was the free speech absolutionists versus those who felt som
158.
by dm319 4y ago
I'm gonna disagree on everything here... > 1. If you don't encounter any trouble daily driving GNU/Linux, that is actually a sign of inexperience. That or you're doing nothing interesting. I do loads of interesting st
159.
by dm319 4y ago
Yes, I remember, even up until very recently, having to google help on Windows. You'd get webpages full of adverts with a heading '12 ways to fix Win10 freezing during upgrade bug!'. And the first two would be something lik
160.
by dm319 4y ago
I think it makes more sense to give figures for consumption rather than distance/energy, as we're usually more interested in how much fuel it will cost us to travel a certain distance. Bit like going into a sweet shop and having
161.
by dm319 4y ago
Fascinating read, wasn't aware of this history of python. I thought the line about the fear of not having a copyright statement for ABC was interesting - and applies to many aspects of life in general where setting things free is the
162.
by dm319 4y ago
The combination of wind farms, solar and large energy storage has huge potential for the UK.
163.
by dm319 4y ago
A reduction in 'pitting people against each other', could paradoxically allow for civil disagreement because of decreased polarisation. I.e. if I go on a platform and I expect strong/aggressive disagreement as my engagement,
164.
by dm319 4y ago
And you were right. I suspect bigots. I miss slashdot's reasons for up/down voting.
165.
by dm319 4y ago
I'm all over the place with pocket computing devices and remain confused. I once has an iphone. Beautifully crafted, both inside and out, but so frustratingly locked down that I was desperate to leave it behind. They have progressiv
166.
by dm319 4y ago
When I was younger I used to believe when people talked about how amazing certain items or experiences were. They were often very expensive, or very hard to get to. I used to believe that they really were such a unique and special experie
167.
by dm319 4y ago
I don't see myself going to the effort/expense of having authentic truffles. It's just a very particular mild taste. I think I can do without it.
168.
by dm319 4y ago
For older patients and those with significant co-morbidities, we often advise against intubation and ICU admission in the UK. Usually if the disease process can't be reversed on the ward with current therapy, it is often unlikely in
169.
by dm319 4y ago
That's weird, the E90 was the last phone I had with reliable phone features. The N900 could be buggy, but I've had iphones and pixels since then and I give answering a phone that is ringing in my pocket to be very often a miss, e
170.
by dm319 4y ago
I think there is more information than that. There are 20 amino acids, so around 1x10^13 possible sequences. This is also a clue as to why we don't have a perfectly rigid system, as a library of T cells capable of recognising every co
171.
by dm319 4y ago
When I got my Nokia E90 in 2007ish, it's hard to describe the power and potential in that device. It was multitasking, 3G, GPS, camera, video, email, web, app store etc. The big downfall of these devices was that consumers weren&#x27
172.
by dm319 4y ago
Are those the shortcuts for it? I can't believe I didn't realise vim had this.
173.
by dm319 4y ago
Yes, I didn't mean impossible, I just mean compared to accumulating new mutations elsewhere, and compared to downregulating surface proteins (which can be the issue in CAR-T).
174.
by dm319 4y ago
Yes good point.
175.
by dm319 4y ago
Yes you are right, I should have said that re-mutation of mutations happen far less often than accumulation of additional mutations. Novel epitopes should be high copy number - and driver mutations will be present in 80-100% of the cancer c
176.
by dm319 4y ago
Yes, CAR-Ts are really a B cell receptor (otherwise known as an antibody) grafted onto a T cell. Antibody directly binds things like proteins, and usually targeted to things found on cell membranes. Also on the cell membrane is MHC-1, whic
177.
by dm319 4y ago
I'm a haematologist who is involved with patients who have CAR-T (I don't do it myself, but do other types of transplant and I look after the patients before and after) and my research area is in the way T cells target cancer. Thi
178.
by dm319 4y ago
OP is talking about CAR-T therapy which is in routine clinical practice. In the UK costs have gone from £600k to around £250K That includes the surrounding medical, nursing and follow up care. In the US costs are likely to be more than
179.
by dm319 4y ago
This is an ongoing discussion in CAR-T. At the moment we only have 'autologous' CAR-T, which means they are manufactured from our own cells. The big advantage to 'allogeneic' CAR-T is that we don't have to take th
180.
by dm319 4y ago
I haven't seen evidence of cancers re-mutating mutations. They tend to develop new mutations (as in the clonal evolution hypothesis), and they can completely change their cell surface expression. But I suspect that they are unlikely

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