Yes you are right, I should have said that re-mutation of mutations happen far less often than accumulation of additional mutations. Novel epitopes should be h

Yes you are right, I should have said that re-mutation of mutations happen far less often than accumulation of additional mutations. Novel epitopes should be high copy number - and driver mutations will be present in 80-100% of the cancer cells. It depends how many cancer cells you get in your biopsy that you sequence I guess. It is easier for a cancer cell to mutate or remove a cell surface protein than to mutate the same mutation targeted, but you are right - that can happen and I'm sure will be a form of treatment resistance for these types of treatment in the future.