dkural

40 ms·

91.
by dkural 3y ago
A knock-out study will work as well as the precise definition and measurement of the phenotype you're looking for will allow. The point you're making is well understood by geneticist. There's about 22K genes in the genome, if
92.
by dkural 4y ago
Boston has a ton of tech and none of the brazen crime and breakdown in social order.
93.
by dkural 4y ago
This seems like a relevant write-up from a Nature science reporter: https://www.nature.com/articles/d41586-023-00968-4
94.
by dkural 4y ago
It's not so much the world that's stopped caring, but there's been no real advance. The Higgs was expected, and found. All the other theories were refuted by the LHC. No new particles, no super-symmetry, nothing. The field
95.
by dkural 4y ago
Land of the free.
96.
by dkural 4y ago
Berkshire is not unique in its ability to buy what you call "distressed" companies. The companies it buys are not usually distressed, but just undervalued by rest of the market. It's entrance into tech is fairly recent. Over
97.
by dkural 4y ago
You are right. There is nothing new here.
98.
by dkural 4y ago
Thank you for the summary and the link. I'd also add that our physical intuition also need not match the "real world", it's a model "good enough" for evolutionary purposes that fails in myriad ways.
99.
by dkural 4y ago
String Theory, "It from (Qu)bit", etc. have been putting out a large amount of B.S. for many years now, and the hype itself became so common that, to compete with other B.S. the hype has now become over-the-top blatant nonsense. M
100.
by dkural 4y ago
It's far from clear that this is the "root cause". There is a good chance any therapeutic effect goes away after larger trials, like every single other drug targeting the same mechanism so far.
101.
by dkural 4y ago
I'm hooked. You should write this up as a screenplay.
102.
by dkural 4y ago
Thank you for the links! Much better than my anecdotal observations :)
103.
by dkural 4y ago
Great engineers don't do all nighters frequently. Some of the best software engineers I've met (quantum computing for Amazon, ML for protein design, etc.), go to bed at reasonably early and get eight hours of sleep, exercise and e
104.
by dkural 4y ago
Thank you!
105.
by dkural 4y ago
It's exactly as you say it - the energy costs are negligible. Most mutation is neutral drift.
106.
by dkural 4y ago
One man's junk is another's treasure. The truth is, a large chunk of it is somewhat "junky". I have a huge problem of using the word "junk" itself, as the word itself comes with so much baggage. When you reall
107.
by dkural 4y ago
This reminds me of the Jedi Mind trick of Uber of waving a smartphone to argue that labor & other laws all of a sudden don't apply to them, to the detriment of the public that'll now shoulder the costs.
108.
by dkural 4y ago
This reminds me of another story - BGI was sequencing the chicken genome, and for a while, a lot of people who did other sequencing projects kept receiving chicken DNA in their sequencing data files (as contamination).
109.
How did you choose between Joplin, Foam, Trilium, Obsidian, Logseq, Roam?
23 points by dkural 4y ago|23 comments
110.
by dkural 4y ago
The Nobel Prize tends to favor initial breakthroughs. Svante's lab sequenced the very first complete Neandertal genome, showing it was possible to reconstruct genomes from ancient DNA, with high-throughput sequencers, and developing th
111.
by dkural 4y ago
We have massive datasets on mutations, and looking at the mutational signatures, there is no evidence that this plays any detectable role in practice, here's some different articles studying such things: https://www.nature.c
112.
by dkural 4y ago
I just saw your reply and just wanted to say I really appreciated your book recommendations! Now reading Huizinga :)
113.
by dkural 4y ago
These two books I read recently are real gems / eye openers for me, which changed my view on many things: Robert C. Allen - The Industrial Revolution: A very short introduction (don't be fooled by the book series, every sentence
114.
by dkural 4y ago
This is a great list. I'll add the following covering related areas: Cancer - by Weinberg Introduction to Proteins - Kessel, Ben-Tal (an older classic is Proteins by Creighton) Developmental Biology - Gilbert Organic Chemistry - Clayd
115.
by dkural 4y ago
This also speaks to a certain lack of inspiration/creativity. A lot of people who end up in graduate school are great at following a prescribed academic path and getting good grades etc. but when confronted with the prospect of origina
116.
by dkural 4y ago
The Standard Model did, in the 50s.
117.
by dkural 4y ago
Here's what I believe leads to a lot of confusion: For most of the 20th century, chemotherapy usually meant small molecules that interfere with cell division, resulting in cellular death. Even in other mechanisms, it wasn't target
118.
by dkural 4y ago
This is a bit off topic: The parent article mentions some higher math talks - out of curiosity, anyone can see one? I don't doubt everything got restored, but I can't seem to find any math.
119.
by dkural 4y ago
Was there an Enron turn-around? Crypto does some mildly useful things, which could justify perhaps 1% of the resources going into it.
120.
by dkural 4y ago
A lot of any kind of popularity might work in this way, not just Art! Did people truly think that 70s hair looked incredible? You might enjoy the work of Pierre Bourdieu, who writes about these issues in depth. There is a reason mass media

More ›