We have massive datasets on mutations, and looking at the mutational signatures, there is no evidence that this plays any detectable role in practice, here's so

We have massive datasets on mutations, and looking at the mutational signatures, there is no evidence that this plays any detectable role in practice, here's some different articles studying such things: https://www.nature.com/articles/nature12477 https://www.nature.com/articles/nature12477 https://www.pnas.org/doi/10.1073/pnas.1210309109 https://www.pnas.org/doi/10.1073/pnas.1210309109 https://www.science.org/doi/10.1126/science.aba7408 https://www.science.org/doi/10.1126/science.aba7408 The known mutational processes entirely dominate the picture as one can see.