dalke

18 ms·

61.
by dalke 2y ago
In the bygone era of 2008, I had fun adding Perl/Ruby-style pattern matching. for line in open("python_yacc.py"): if line =~ m/def (\w+)/: print repr($1) See http://www.dalkescienti
62.
by dalke 2y ago
Here is a problem I've been noodling with. If you are a decent programmer, how does your LLM help you solve this problem? Given a cheminformatics fingerprint definition based on SMARTS substructure patterns, come up with a screening fi
63.
by dalke 2y ago
> These "wallets" are not used for financial transactions, they're for credentials. Which is why I gave other examples of the human factors issues, not just financial transactions: configurable cookie warnings, configurabl
64.
by dalke 2y ago
My question remains: to what extent is selective disclosure useful given the demonstrable human factors failures in existing selective disclosure systems? User agreements are another example of failure. They give full disclosure, on a take-
65.
by dalke 2y ago
So you think that selective disclosure isn't all that useful without all of the above? Who will do the education? The banks? The schools? If the latter, what subjects will be removed from the curriculum? Who will verify the AI is train
66.
by dalke 2y ago
> great ideas in this, like selective disclosure How will a centralized wallet used for everything solve the human factors problems? We know there's a deep human factors issue here. Web sites and apps ask for permission seemingly al
67.
by dalke 2y ago
Last time I was in Switzerland, back in 2015 or so, the B&B I stayed in was cash only. The stay cost something like 500 CHF, or nearly 600 USD.
68.
by dalke 2y ago
More and more places here in Sweden do not accept cash, and I don't like it. I have the usual personal reasons: - I don't like individualized tracking, - there's no backup solution if my stuff gets stolen (10 years ago my ban
69.
by dalke 2y ago
Bank provided causes problems with people who don't have bank accounts. Here in Sweden most people use bank-provided electronic ID called "BankID". Quoting "Foreign citizens in Sweden blocked from BankID after several ba
70.
by dalke 2y ago
Ideally, a Sweden would be taking the considerable parental leave policy - over one year distributed among both parents, and preschool starts at 1 year old, so working parents don't often need to have the kid present while working. The
71.
by dalke 2y ago
Back in the 90s I implemented a ribbon diagram representation for VMD, a visualization program. The first problem is secondary structure assignment, that is, which are the alpha helices, beta sheets, and other (coil/turns). The standar
72.
by dalke 2y ago
Yes, and someone followed up with that suggestion. But the problem is that someone needs to do it. Jan Labanowski is xkcd's "random person in Nebraska", a computational chemist volunteering unpaid time, on a 30 year old code
73.
by dalke 2y ago
Because the person who is charge is not a software developer, systems administrator, or anything like your background, so is unable to explain things in your terms.
74.
by dalke 2y ago
Chrome's ability to control how people interact with the world is also contributing to the death of the old, independent web. From an email yesterday from the administrator of the Computational Chemistry List (which started in 1991), a
75.
by dalke 2y ago
Last fall I almost missed my ferry because my train up to Hamburg was so delayed that it missed my connection to Kiel, and my backup connection pulled out just as my arriving train was stopping. I knew things were getting bad in Germany so
76.
by dalke 2y ago
It is the most widely used FOSS package in its domain, with Open Babel and CDK as the main alternatives. RDKit has far more active development. The "machine learning" part is mostly historical. When RDKit started there were few p
77.
by dalke 2y ago
I knew one of those too. I consulted for a company across the street from the Palo Alto general aviation airport. The doc/pubs manager lived some place north of Sonoma. She would fly in, walk across the street, and go to work. At anoth
78.
by dalke 2y ago
When I was a kid in Miami, I read about people commuting to work by jet ski. This was before they replaced the Rickenbacker Causeway drawbridge with the William Powell Bridge, and the commute from Key Biscayne into Miami could be delayed an
79.
by dalke 2y ago
Yes, you have the right understanding. I plan to be at the RDKit User Group meeting in Germany this fall. You might think of participating, even remotely.
80.
by dalke 2y ago
My comment about SMILES strings size was meant to highlight how the 20 bytes you use is quite a lot of data. Yes, the binary RDMol is larger than the SMILES - it can also store more data, including coordinates and extended stereochemistry,
81.
by dalke 2y ago
If I follow it correctly, you've reduced the search time by pre-computing some of the comparison information and storing it into the database. This increases the database creation time but decreases the search time. You've decided
82.
by dalke 2y ago
???? Sweden is a great country to be a parent. Source: I'm an immigrant to Sweden with two Swedish-born kids. My mother was one of 8. That doesn't make rural Michigan in the 1950s a great place to be a parent. That means, as an au
83.
by dalke 2y ago
My Mom's a widower living on her husband's pension. My sister and her spouse both work, with good incomes. Of course my sister paid my Mom to babysit the grandkids.
84.
by dalke 2y ago
I think it's because the author's native language is Swedish and had a harder time seeing mistakes which use Swedish instead of English. "There were no adress and the" is another example - the Swedish is "adress&quo
85.
by dalke 2y ago
I'm old enough that my father worked for one of those "golden age" companies. https://en.wikipedia.org/wiki/Wometco_Enterprises It was a conglomerate, starting with theaters then adding TV and other ente
86.
by dalke 2y ago
As someone in the EU, I can say that's not realistic. The apps for my bank, the local bus transit system, electronic payments, and even my kid's school, are only available for iOS and Android, and the first three use Google exclus
87.
by dalke 2y ago
FWIW, the traditional, 1980s approach uses fingerprints, which are binary vectors. Here's the same search using RDKit's "Morgan" fingerprints, with radius 2, and count enumeration simulation enabled, using my "chemf
88.
by dalke 2y ago
That's far from enough. I set up a company, had a no-cost+open source version for download, and a money+open source version ("commercial") for purchase, both with an MIT license. The commercial version was faster, with more f
89.
by dalke 3y ago
Quakes came out in, what, 1996? And was written by some of the foremost practitioners of computer graphics? We were a couple of physics grad students working on a side project in late 1993. My background was a semester course based on Foley
90.
by dalke 3y ago
We've talked before about our respective molecular graphics background. I started with Unix on a Personal IRIS as an undergrad working in a physics lab which used it for imaging capture and analysis. I was the nominal sys admin, with o

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