borski

31 ms·

541.
by borski 2y ago
"No side effect whatsoever" is not what anyone is claiming.
542.
by borski 2y ago
What is the alternative? Sure, I agree people misuse medications sometimes. So should we not help people curb their obesity and/or T2D because some folks misuse it? Of course not. People misuse Sudafed and use it to make meth, or drink
543.
by borski 2y ago
That's great! But I guarantee you there is a discernible change in behavior to them .
544.
by borski 2y ago
Not in the way you're implying. I should mention that I'm in a clinical trial for CagriSema (and it's a head-to-head efficacy trial against tirzepatide, so not blind, with no placebo, but randomized), so I am speaking from ex
545.
by borski 2y ago
True. It would be a good time to short some candy companies. Soda companies will figure it out by releasing lots of diet sodas and energy drinks and so on. See's? Their generation might be dying soon, heh
546.
by borski 2y ago
It's hard to differentiate because so many of the positive effects of GLP-1 drugs correlate so well with just... weight loss. So in that sense, we will have to see - but if obesity and/or T2D is a trigger for lots of other disease
547.
by borski 2y ago
These drugs are not quite as new as often reported. Byetta has been around since 2005 and Victoza since 2010. The difference is that the latest iteration of GLP-1 meds are more effective, and we've discovered they can help with a lot m
548.
by borski 2y ago
> I feel that many people have never really tried, or tried but did not appreciate that it would be really hard, and gave up. With all due respect, this is nonsense. This is a very common trope, but I can guarantee you the vast vast vast
549.
by borski 2y ago
> This is not the case with Ozempic. If you take it to lose weight then cessation will cause rapid weight gain. You'll be stuck with it for the rest of your life, for something that can [again] usually be permanently solved with oth
550.
by borski 2y ago
That’s a pretty cynical view. In essence, what you’re saying is “all the things you care about are not things I care about and/or actually despise.” And that’s OK - you don’t have to work at Amazon! But the implication is that the OP h
551.
by borski 2y ago
> I don't get the diverse conclusion. I don't resonate with it at all. We were all relatively poor, of the same race and had very similar upbringings and possible futures. We were similar in more ways than different, and that w
552.
by borski 2y ago
This was my life as a kid. It was wonderful. I made and maintained some of my best friendships literally just going to or from home on the subway with schoolmates.
553.
by borski 2y ago
I grew up in NYC, down at the end of Brooklyn by Coney Island / Brighton Beach. My entire life, I have always called the NYC Subway the “great equalizer.” For a tiny sum of money (75 cents when I was a kid, just over $2 now) you could
554.
by borski 2y ago
> Startups that go to zero tend to do so fairly quickly. I wish this were true. Far too many founders are willing to stick it out in hopes that if they just keep building, sales will come. Of course, it doesn't, so they waste a deca
555.
by borski 2y ago
People love to wish this weren’t true, but it is. All engineers have great potential, but some realize it faster than others, and some never fully realize it at all. The difference is significant. Moreover, not all spectacular engineers are
556.
by borski 2y ago
The idea is to focus on creating value that fits your morals and values, not just to focus on “creating value for VCs” which is what usually begets the “scale at all costs” conversation that has been so popular during the ZIRP we’ve lived t
557.
by borski 2y ago
I think the idea is that by maintaining a strong military presence, thus preventing us from being directly attacked on our soil (in theory), affects many more people’s lives indirectly, since they aren’t living in fear that they could be ta
558.
by borski 2y ago
Millions of people don’t wear Meta Raybans yet, and headphones aren’t generally recording me without my permission. In CA, recording me in a setting where I have the expectation of privacy is illegal, unless you have asked my permission fir
559.
by borski 2y ago
Honestly, that might be my favorite part
560.
by borski 2y ago
If you’ve never written software that needed to be used by tens of thousands or hundreds of thousands of people, then sure, it could seem that way.
561.
by borski 2y ago
https://www.quora.com/Why-are-software-development-task-esti...
562.
by borski 2y ago
Everything is a “simple thing” unless you’re the one implementing it. Things that seem simple on the surface rarely are, especially long-term.
563.
by borski 2y ago
Wait, what? You can browse files on the iPhone just fine.
564.
by borski 2y ago
Because nobody has ever jumped over one of those or triggered the motion sensor on the other side of those paddle gates or gone around the side or underneath...
565.
by borski 2y ago
I don't think the contention was that the feature or ability doesn't exist, but rather that companies choose not to do it. When you worked on those systems - did you set up anti-passbacks?
566.
by borski 2y ago
And also pay for the people to enforce it. Yes, some places do. But those places are rare.
567.
by borski 2y ago
> I suppose the expense, and the risk in relying on employees, is gonna be quite relative to the organization and its priorities. Of course. If you work in a SCIF, you're going to have a very different set of rules and experiences
568.
by borski 2y ago
Someone I worked with very closely for many years really wanted to be Forbes 30 under 30. They never got it, but got plenty of other random awards that didn’t matter. I never really understood it, because it was so clearly BS; it didn’t h
569.
by borski 2y ago
Great question; not to my knowledge. There would be many false positives, especially as people bring in guests. Sometimes guests get a temp badge; at many companies, they get a sticker to put on their shirt and get tapped in by their host,
570.
by borski 2y ago
That’s not how CISOs get promoted. If a CISO presented it this way, the very obvious next question is “and how much will it cost us to fix” followed by “and how much will insurance cover,” which are both going to blow the reputational damag

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