bglazer

10 ms·

121.
Phased Array Microphone (2023)(benwang.dev)
600 points by bglazer 2y ago|187 comments
122.
by bglazer 2y ago
I would prefer that the United States scale back military spending while negotiating arms controls agreements with our major adversaries. Arms races are mutually destructive. They distort the economies and political incentives of all countr
123.
by bglazer 2y ago
I think you’re overstating the “proven” effect of water fasting. That said I’m surprised and happy to see that several academic medical centers are running trials of fastingin conjunction with chemotherapy. https://www.cedars-sin
124.
by bglazer 2y ago
This is true in the large sense but it obscures that 5 year survival rates have been steadily extending for many people who already have cancer. Treatments are in fact improving
125.
by bglazer 2y ago
You realize AlphaFold was trained on thousands of protein sequences generated via (I'd guess) tens of millions of hours of human labor.
126.
by bglazer 2y ago
Isn’t the whole point of this research that people Okinawa and Italy probably don’t live any longer. In fact these areas have shorter average life span? So, all the stories about the benefit of the Mediterranean fish heavy diet are post-hoc
127.
by bglazer 2y ago
Really interesting point about the non-correlation of affinity and PPI probabilities. Disappointing, honestly. Mechanistic systems bio models would really benefit from large scale affinity information, and it would be pretty cool if ML meth
128.
by bglazer 2y ago
Genuinely curious, how is binding affinity prediction not PPI prediction? Isn’t a PPI just a binarization of affinity?
129.
by bglazer 2y ago
The UCSC genome browser is the best way to find where genes are mapped to in DNA. Here's a link that shows ACHE (acetylcholinesterase) and RELN (reelin) in the same view. https://genome.ucsc.edu/cgi-bin/hgTracks?db
130.
by bglazer 2y ago
I'm not sure how you're getting the 4 genes away thing, I'm seeing like 20-30 genes and more than 2 megabases of distance in between RLN and ACHE. I'd be surprised if they were even in the same topologically associated d
131.
by bglazer 2y ago
This is magical thinking. Like, the laws of physics still apply. Computation depends on power generation, and both *require* physical objects that break and decay. Who fixes the broken stuff when all the humans are dead?
132.
by bglazer 2y ago
Emil Kirkegaard is a self-described white nationalist eugenicist who thinks the age of consent is too high. I wouldn't trust anything he has to say.
133.
by bglazer 2y ago
How would the AI keep itself running?
134.
by bglazer 2y ago
If AI has no economic impact, it almost by definition also has no ability to marshal the kind of resources necessary to destroy all of humanity. All the doom scenarios seem to rely on quasi-magical abilities springing from advanced intelli
135.
by bglazer 2y ago
How many people and resources (dollars) would you estimate are involved in professional track and field? Bonus points if you express this as a proportion of total human population and economic activity
136.
by bglazer 2y ago
Yes, spaced repetition and regular testing are effective in a purely mechanical sense. They’re good ways to acquire knowledge and skills. But, it’s really worth noting second order considerations. Does the median student enjoy the testing a
137.
by bglazer 2y ago
I’m begging everyone on HN to understand that Michael Levin’s work is not the beginning and end of biology. This is not meant to disparage his research, it’s really quite cool, but bioelectric signaling is just one piece of a very complex,
138.
by bglazer 2y ago
Yep email me!
139.
by bglazer 2y ago
Interesting stuff! I'm mostly thinking individual cells in a multicellular organism (i.e. lung cells in a person). It is indeed very hard to understand what they are optimizing for. Obviously, the organism as a whole is under selective
140.
by bglazer 2y ago
Great post, you're clearly on the right track. I totally agree that there is a major gap in modern theoretical understanding of how and why complex systems emerge. Breakthroughs in understanding the physical/informational processe
141.
by bglazer 2y ago
elephant repellent problem? What is that? This is literally the first occurrence of that string on the internet.
142.
by bglazer 2y ago
The reason I know this is I made the same mistake in a comment on a similar story a few weeks ago!
143.
by bglazer 2y ago
This is actually not totally correct. AAV’s form episomes, which are circular DNA structures that are basically extra chromosomes. The fact that AAV’s don’t randomly insert themselves into DNA makes them safer for clinical uses like this.
144.
Giant Current Ripples(en.wikipedia.org)
5 points by bglazer 2y ago|0 comments
145.
by bglazer 2y ago
Denied is just the inverse of “granted” which is the standard way to say a tenure application was accepted
146.
by bglazer 2y ago
The thing about “figuring out the true nature of the universe” is that you *have to do experiments*. It’s non-negotiable. There’s no amount of really hard thinking or parameters or GPU’s that will let you know the secrets of the universe. I
147.
by bglazer 2y ago
This is a Scientific Reports paper, which is way less prestigious and evidently has much less rigorous review compared to Nature. Still, shame on them for publishing this
148.
by bglazer 2y ago
Crank bullshit alarms at level 11 with this paper Quote from the paper: “ God created the perfect quantum computer: the DNA.”
149.
by bglazer 2y ago
Isn’t the same true of familial versus stranger abductions in the US? Like the vast majority are familial, correct?
150.
by bglazer 2y ago
Yeah that’s all correct. It’s particularly notable because the study was a third line treatment. These patients had already progressed after taking a platinum based chemotherapy, which is a standard first treatment, and they also progressed

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